Gene Review:
GRPR - gastrin-releasing peptide receptor
Homo sapiens
Synonyms:
BB2, GRP-R, GRP-preferring bombesin receptor, Gastrin-releasing peptide receptor
Roesler,
Henriques,
Schwartsmann,
Shriver,
Bourdeau,
Gubish,
Tirpak,
Davis,
Luketich,
Siegfried,
Roesler,
Luft,
Oliveira,
Farias,
Almeida,
Quevedo,
Dal Pizzol,
Schröder,
Izquierdo,
Schwartsmann,
Hellmich,
Ives,
Udupi,
Soloff,
Greeley,
Christensen,
Townsend,
Scott,
Millward,
Cartwright,
Preston,
Coletta,
- Sex-specific expression of gastrin-releasing peptide receptor: relationship to smoking history and risk of lung cancer. Shriver, S.P., Bourdeau, H.A., Gubish, C.T., Tirpak, D.L., Davis, A.L., Luketich, J.D., Siegfried, J.M. J. Natl. Cancer Inst. (2000)
- Phosphorylation of focal adhesion kinase tyrosine 397 critically mediates gastrin-releasing peptide's morphogenic properties. Glover, S., Delaney, M., Dematte, C., Kornberg, L., Frasco, M., Tran-Son-Tay, R., Benya, R.V. J. Cell. Physiol. (2004)
- Expression of mRNA for three bombesin receptor subtypes in human bronchial epithelial cells. DeMichele, M.A., Davis, A.L., Hunt, J.D., Landreneau, R.J., Siegfried, J.M. Am. J. Respir. Cell Mol. Biol. (1994)
- Increased frequency of gastrin-releasing peptide receptor gene mutations during colon-adenocarcinoma progression. Glover, S.C., Tretiakova, M.S., Carroll, R.E., Benya, R.V. Mol. Carcinog. (2003)
- Presence of receptors for bombesin/gastrin-releasing peptide and mRNA for three receptor subtypes in human prostate cancers. Sun, B., Halmos, G., Schally, A.V., Wang, X., Martinez, M. Prostate (2000)
- Molecular mechanisms mediating gastrin-releasing peptide receptor modulation of memory consolidation in the hippocampus. Roesler, R., Luft, T., Oliveira, S.H., Farias, C.B., Almeida, V.R., Quevedo, J., Dal Pizzol, F., Schröder, N., Izquierdo, I., Schwartsmann, G. Neuropharmacology (2006)
- Gastrin-releasing Peptide receptor as a molecular target for psychiatric and neurological disorders. Roesler, R., Henriques, J.A., Schwartsmann, G. CNS & neurological disorders drug targets. (2006)
- Exclusion of the gastrin-releasing peptide receptor (GRPR) locus as a candidate gene for Rett syndrome. Heidary, G., Hampton, L.L., Schanen, N.C., Rivkin, M.J., Darras, B.T., Battey, J., Francke, U. Am. J. Med. Genet. (1998)
- Gastrin-releasing peptide receptor (GRPR) locus in Japanese subjects with autism. Marui, T., Hashimoto, O., Nanba, E., Kato, C., Tochigi, M., Umekage, T., Kato, N., Sasaki, T. Brain Dev. (2004)
- Gastrin-releasing peptide receptor-mediated autocrine growth in squamous cell carcinoma of the head and neck. Lango, M.N., Dyer, K.F., Lui, V.W., Gooding, W.E., Gubish, C., Siegfried, J.M., Grandis, J.R. J. Natl. Cancer Inst. (2002)
- Gastrin-releasing peptide receptors in the human prostate: relation to neoplastic transformation. Markwalder, R., Reubi, J.C. Cancer Res. (1999)
- Selective targeting and inducible destruction of human cancer cells by retroviruses with envelope proteins bearing short peptide ligands. Gollan, T.J., Green, M.R. J. Virol. (2002)
- Effect of bombesin, gastrin-releasing peptide (GRP)(14-27) and bombesin/GRP receptor antagonist RC-3095 on growth of nitrosamine-induced pancreatic cancers in hamsters. Szepeshazi, K., Schally, A.V., Groot, K., Halmos, G. Int. J. Cancer (1993)
- Stimulation of proliferation and migration of a colorectal cancer cell line by amidated and glycine-extended gastrin-releasing peptide via the same receptor. Patel, O., Dumesny, C., Giraud, A.S., Baldwin, G.S., Shulkes, A. Biochem. Pharmacol. (2004)
- Autism and multiple exostoses associated with an X;8 translocation occurring within the GRPR gene and 3' to the SDC2 gene. Ishikawa-Brush, Y., Powell, J.F., Bolton, P., Miller, A.P., Francis, F., Willard, H.F., Lehrach, H., Monaco, A.P. Hum. Mol. Genet. (1997)
- Gastrin-releasing peptide mediates its morphogenic properties in human colon cancer by upregulating intracellular adhesion protein-1 (ICAM-1) via focal adhesion kinase. Taglia, L., Matusiak, D., Matkowskyj, K.A., Benya, R.V. Am. J. Physiol. Gastrointest. Liver Physiol. (2007)
- Gastrin releasing peptide and gastrin releasing peptide receptor expression in gastrointestinal carcinoid tumours. Scott, N., Millward, E., Cartwright, E.J., Preston, S.R., Coletta, P.L. J. Clin. Pathol. (2004)
- Gastrin-releasing peptide receptor mediates activation of the epidermal growth factor receptor in lung cancer cells. Thomas, S.M., Grandis, J.R., Wentzel, A.L., Gooding, W.E., Lui, V.W., Siegfried, J.M. Neoplasia (2005)
- Androgen-dependent expression of the gastrin-releasing Peptide receptor in human prostate tumor xenografts. de Visser, M., van Weerden, W.M., de Ridder, C.M., Reneman, S., Melis, M., Krenning, E.P., de Jong, M. J. Nucl. Med. (2007)
- In situ hybridization for gastrin-releasing peptide receptor (GRP receptor) expression in prostatic carcinoma. Bartholdi, M.F., Wu, J.M., Pu, H., Troncoso, P., Eden, P.A., Feldman, R.I. Int. J. Cancer (1998)
- MicroPET Imaging of Breast Cancer Using Radiolabeled Bombesin Analogs Targeting the Gastrin-releasing Peptide Receptor. Parry, J.J., Andrews, R., Rogers, B.E. Breast Cancer Res. Treat. (2007)
- Gastrin-releasing peptide-induced down-regulation of tumor suppressor protein PTEN (phosphatase and tensin homolog deleted on chromosome ten) in neuroblastomas. Qiao, J., Kang, J., Cree, J., Evers, B.M., Chung, D.H. Ann. Surg. (2005)
- Multiple protein kinase pathways are involved in gastrin-releasing peptide receptor-regulated secretion. Hellmich, M.R., Ives, K.L., Udupi, V., Soloff, M.S., Greeley, G.H., Christensen, B.N., Townsend, C.M. J. Biol. Chem. (1999)
- Aberrant expression of gastrin-releasing peptide and its receptor by well-differentiated colon cancers in humans. Carroll, R.E., Matkowskyj, K.A., Chakrabarti, S., McDonald, T.J., Benya, R.V. Am. J. Physiol. (1999)
- Human gastrin-releasing peptide receptor mediates sustained CREB phosphorylation and transactivation in HuTu 80 duodenal cancer cells. Qu, X., Xiao, D., Weber, H.C. FEBS Lett. (2002)
- Constitutive activation of the gastrin-releasing peptide receptor expressed by the nonmalignant human colon epithelial cell line NCM460. Ferris, H.A., Carroll, R.E., Rasenick, M.M., Benya, R.V. J. Clin. Invest. (1997)
- Signaling mechanisms regulating bombesin-mediated AP-1 gene induction in the human gastric cancer SIIA. Kim, H.J., Evers, B.M., Litvak, D.A., Hellmich, M.R., Townsend, C.M. Am. J. Physiol., Cell Physiol. (2000)
- Activation of extracellular signal-regulated kinase mediates bombesin-induced mitogenic responses in prostate cancer cells. Xiao, D., Qu, X., Weber, H.C. Cell. Signal. (2003)
- Expression of progastrin-releasing peptide and gastrin-releasing peptide receptor mRNA transcripts in tumor cells of patients with small cell lung cancer. Uchida, K., Kojima, A., Morokawa, N., Tanabe, O., Anzai, C., Kawakami, M., Eto, Y., Yoshimura, K. J. Cancer Res. Clin. Oncol. (2002)
- Characterization of a bombesin/gastrin-releasing peptide receptor on a human gastric-cancer cell line. Preston, S.R., Woodhouse, L.F., Gokhale, J., Miller, G.V., Primrose, J.N. Int. J. Cancer (1994)