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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Dapsone-induced motor polyneuropathy. A complication of prolonged treatment of subcorneal pustular dermatosis.

A motor polyneuropathy developed in a woman with subcorneal pustular dermatosis of 16 years' duration, who had received at least 300 gm of dapsone over a five-year period and 80 gm during the four-month period of progression of her neurologic symptoms. Although the patient believed her muscle power had returned to normal four months after the drug was stopped, a slight peripheral neuropathy remained. Electrodiagnostic and clinical features during the period of greatest weakness and the subsequent 16 months were consistent with a polyneuropathy of the axonal type. The neurotoxicity of dapsone appears to be dose-dependent, but the mechanism by which it occurs is unknown.[1]

References

  1. Dapsone-induced motor polyneuropathy. A complication of prolonged treatment of subcorneal pustular dermatosis. Fredericks, E.J., Kugelman, T.P., Kirsch, N. Archives of dermatology. (1976) [Pubmed]
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