The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Disulone     4-(4- aminophenyl)sulfonylaniline

Synonyms: Sulfona, dapsone, Avlosulfone, DADPS, Dapsoderm-X, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Disulone


Psychiatry related information on Disulone


High impact information on Disulone


Chemical compound and disease context of Disulone


Biological context of Disulone


Anatomical context of Disulone


Associations of Disulone with other chemical compounds


Gene context of Disulone

  • Sigmoidal kinetic characteristics were observed for carbamazepine metabolism by CYP3A4 and naphthalene metabolism by CYPs 2B6, 2C8, 2C9, and 3A5 as well as dapsone metabolism by CYP2C9 [32].
  • Recent studies of the human Pneumocystis carinii dihydropteroate synthase (DHPS) gene suggest that P. carinii is developing resistance to sulfamethoxazole (SMX) and dapsone [33].
  • Drugs which are metabolised by CYP3A and are likely to be used in the treatment of patients with HIV disease include the azole antifungals, macrolide antibiotics and dapsone; therefore, protease inhibitors may interact with these drugs [34].
  • Dapsone blocked the activity of HS-LP but not MPO [35].
  • The apparent Km for the structurally related sulphone antibiotic dapsone was 5-fold lower for the slow variant NAT2 7B when compared with the wild-type NAT2 4 [36].

Analytical, diagnostic and therapeutic context of Disulone


  1. Dapsone-induced methemoglobinemia in a patient with P. carinii pneumonia and AIDS. Reiter, W.M., Cimoch, P.J. N. Engl. J. Med. (1987) [Pubmed]
  2. The inhibition of polymorphonuclear leukocyte cytotoxicity by dapsone. A possible mechanism in the treatment of dermatitis herpetiformis. Stendahl, O., Molin, L., Dahlgren, C. J. Clin. Invest. (1978) [Pubmed]
  3. Cancer mortality among patients with Hansen's disease. Brinton, L.A., Hoover, R., Jacobson, R.R., Fraumeni, J.F. J. Natl. Cancer Inst. (1984) [Pubmed]
  4. Multidrug-resistance to dapsone, rifampicin, and ofloxacin in Mycobacterium leprae. Cambau, E., Perani, E., Guillemin, I., Jamet, P., Ji, B. Lancet (1997) [Pubmed]
  5. Sulphone resistance in leprosy. A review of one hundred proven clinical cases. Pearson, J.M., Rees, R.J., Waters, M.F. Lancet (1975) [Pubmed]
  6. Dapsone to delay symptoms in Creutzfeldt-Jakob disease. Manuelidis, L., Fritch, W., Zaitsev, I. Lancet (1998) [Pubmed]
  7. Genetic predisposition to bladder cancer: ability to hydroxylate debrisoquine and mephenytoin as risk factors. Kaisary, A., Smith, P., Jaczq, E., McAllister, C.B., Wilkinson, G.R., Ray, W.A., Branch, R.A. Cancer Res. (1987) [Pubmed]
  8. Dapsone or electric shock therapy of brown recluse spider envenomation? Barrett, S.M., Romine-Jenkins, M., Fisher, D.E. Annals of emergency medicine. (1994) [Pubmed]
  9. Evaluation of a continual compliance monitoring program for dapsone in an outpatient Hansen's disease clinic. Fischer, J.H., West, D.P., Worobec, S.M. Int. J. Lepr. Other Mycobact. Dis. (1986) [Pubmed]
  10. Atovaquone compared with dapsone to prevent Pneumocystis carinii pneumonia. Horowitz, H.W., Wormser, G.P. N. Engl. J. Med. (1999) [Pubmed]
  11. A randomized trial of three antipneumocystis agents in patients with advanced human immunodeficiency virus infection. NIAID AIDS Clinical Trials Group. Bozzette, S.A., Finkelstein, D.M., Spector, S.A., Frame, P., Powderly, W.G., He, W., Phillips, L., Craven, D., van der Horst, C., Feinberg, J. N. Engl. J. Med. (1995) [Pubmed]
  12. A new model for dermatitis herpetiformis that uses HLA-DQ8 transgenic NOD mice. Marietta, E., Black, K., Camilleri, M., Krause, P., Rogers, R.S., David, C., Pittelkow, M.R., Murray, J.A. J. Clin. Invest. (2004) [Pubmed]
  13. Spectrofluorescent detection of in vivo red cell lipid peroxidation in patients treated with diaminodiphenylsulfone. Goldstein, B.D., McDonagh, E.M. J. Clin. Invest. (1976) [Pubmed]
  14. Pyrimethamine/dapsone resistant falciparum malaria imported from Kenya. Herzog, C., Lambert, H.P., Maudgal, D., Warhurst, D.C., Rogers, R.J. Lancet (1982) [Pubmed]
  15. Oral dapsone versus nebulized pentamidine for Pneumocystis carinii pneumonia prophylaxis: an open randomized prospective trial to assess efficacy and haematological toxicity. Slavin, M.A., Hoy, J.F., Stewart, K., Pettinger, M.B., Lucas, C.R., Kent, S.J. AIDS (1992) [Pubmed]
  16. Metabolism of dapsone to its hydroxylamine by CYP2E1 in vitro and in vivo. Mitra, A.K., Thummel, K.E., Kalhorn, T.F., Kharasch, E.D., Unadkat, J.D., Slattery, J.T. Clin. Pharmacol. Ther. (1995) [Pubmed]
  17. Hyperosmolar nonketotic diabetic syndrome following treatment of human immunodeficiency virus infection with didanosine. Munshi, M.N., Martin, R.E., Fonseca, V.A. Diabetes Care (1994) [Pubmed]
  18. Myeloperoxidase as a generator of drug free radicals. Uetrecht, J.P. Biochem. Soc. Symp. (1995) [Pubmed]
  19. Drug interactions in use of dapsone for Pneumocystis carinii prophylaxis. Horowitz, H.W., Jorde, U.P., Wormser, G.P. Lancet (1992) [Pubmed]
  20. Effects of the antacids in didanosine tablets on dapsone pharmacokinetics. Sahai, J., Garber, G., Gallicano, K., Oliveras, L., Cameron, D.W. Ann. Intern. Med. (1995) [Pubmed]
  21. Selective inhibition of human neutrophil chemotaxis to N-formyl-methionyl-leucyl-phenylalanine by sulfones. Harvath, L., Yancey, K.B., Katz, S.I. J. Immunol. (1986) [Pubmed]
  22. Pregnancy in relapsing polychondritis: twenty-five pregnancies in eleven patients. Papo, T., Wechsler, B., Bletry, O., Piette, A.M., Godeau, P., Piette, J.C. Arthritis Rheum. (1997) [Pubmed]
  23. Dapsone for thrombocytopenic purpura related to human immunodeficiency virus infection. Durand, J.M., Lefèvre, P., Hovette, P., Issifi, S., Mongin, M. Am. J. Med. (1991) [Pubmed]
  24. Sulfasalazine metabolites and dapsone attenuate formyl-methionyl-leucyl-phenylalanine-induced mucosal injury in rat ileum. von Ritter, C., Grisham, M.B., Granger, D.N. Gastroenterology (1989) [Pubmed]
  25. Hemolytic anemia induced by dapsone transmitted through breast milk. Sanders, S.W., Zone, J.J., Foltz, R.L., Tolman, K.G., Rollins, D.E. Ann. Intern. Med. (1982) [Pubmed]
  26. The use of dapsone in the treatment of giant cell arteritis and polymyalgia rheumatica. Doury, P., Pattin, S., Eulry, F., Thabaut, A. Arthritis Rheum. (1983) [Pubmed]
  27. Intracellular glutathione in the peripheral blood cells of HIV-infected patients: failure to show a deficiency. Pirmohamed, M., Williams, D., Tingle, M.D., Barry, M., Khoo, S.H., O'Mahony, C., Wilkins, E.G., Breckenridge, A.M., Park, B.K. AIDS (1996) [Pubmed]
  28. Low-dose co-trimoxazole, aerosolised pentamidine, or dapsone plus pyrimethamine for prevention of Pneumocystis carinii pneumonia. Mallolas, J., Zamora, L., Gatell, J.M., Miró, J.M., Soriano, E. Lancet (1991) [Pubmed]
  29. Primary prophylaxis for Pneumocystis carinii pneumonia: a randomized trial comparing cotrimoxazole, aerosolized pentamidine and dapsone plus pyrimethamine. Mallolas, J., Zamora, L., Gatell, J.M., Miró, J.M., Vernet, E., Valls, M.E., Soriano, E., SanMiguel, J.G. AIDS (1993) [Pubmed]
  30. Prophylaxis for human immunodeficiency virus-related Pneumocystis carinii pneumonia: using simulation modeling to inform clinical guidelines. Goldie, S.J., Kaplan, J.E., Losina, E., Weinstein, M.C., Paltiel, A.D., Seage, G.R., Craven, D.E., Kimmel, A.D., Zhang, H., Cohen, C.J., Freedberg, K.A. Arch. Intern. Med. (2002) [Pubmed]
  31. Comparison of the dapsone recovery ratio and the erythromycin breath test as in vivo probes of CYP3A activity in patients with rheumatoid arthritis receiving cyclosporine. Stein, C.M., Kinirons, M.T., Pincus, T., Wilkinson, G.R., Wood, A.J. Clin. Pharmacol. Ther. (1996) [Pubmed]
  32. Evaluation of atypical cytochrome P450 kinetics with two-substrate models: evidence that multiple substrates can simultaneously bind to cytochrome P450 active sites. Korzekwa, K.R., Krishnamachary, N., Shou, M., Ogai, A., Parise, R.A., Rettie, A.E., Gonzalez, F.J., Tracy, T.S. Biochemistry (1998) [Pubmed]
  33. Pneumocystis carinii dihydropteroate synthase but not dihydrofolate reductase gene mutations correlate with prior trimethoprim-sulfamethoxazole or dapsone use. Ma, L., Borio, L., Masur, H., Kovacs, J.A. J. Infect. Dis. (1999) [Pubmed]
  34. Protease inhibitors in patients with HIV disease. Clinically important pharmacokinetic considerations. Barry, M., Gibbons, S., Back, D., Mulcahy, F. Clinical pharmacokinetics. (1997) [Pubmed]
  35. Leukocyte myeloperoxidase and salivary lactoperoxidase: identification and quantitation in human mixed saliva. Thomas, E.L., Jefferson, M.M., Joyner, R.E., Cook, G.S., King, C.C. J. Dent. Res. (1994) [Pubmed]
  36. Enzyme kinetic properties of human recombinant arylamine N-acetyltransferase 2 allotypic variants expressed in Escherichia coli. Hickman, D., Palamanda, J.R., Unadkat, J.D., Sim, E. Biochem. Pharmacol. (1995) [Pubmed]
  37. Regression of Kaposi's sarcoma in AIDS after treatment with dapsone. Poulsen, A., Hultberg, B., Thomsen, K., Wantzin, G.L. Lancet (1984) [Pubmed]
  38. Demonstration of dapsone in urine and serum by ELISA inhibition. Huikeshoven, H., Landheer, J.E., van Denderen, A.C., Vlasman, M., Leiker, D.L., Das, P.K., Goldring, O.L., Pondman, K.W. Lancet (1978) [Pubmed]
  39. Dapsone, trimethoprim, and sulfamethoxazole plasma levels during treatment of Pneumocystis pneumonia in patients with the acquired immunodeficiency syndrome (AIDS). Evidence of drug interactions. Lee, B.L., Medina, I., Benowitz, N.L., Jacob, P., Wofsy, C.B., Mills, J. Ann. Intern. Med. (1989) [Pubmed]
  40. A comparison of the effectiveness of three regimens in the prevention of Pneumocystis carinii pneumonia in human immunodeficiency virus-infected patients. Martin, M.A., Cox, P.H., Beck, K., Styer, C.M., Beall, G.N. Arch. Intern. Med. (1992) [Pubmed]
  41. Activity of oxidative routes of metabolism of debrisoquin, mephenytoin, and dapsone is unrelated to the pathogenesis of vinyl chloride-induced disease. Black, C., May, G., Csuka, M.E., Lupoli, S., Wilkinson, G.R., Branch, R.A. Clin. Pharmacol. Ther. (1992) [Pubmed]
WikiGenes - Universities