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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Hepatitis C virus NS3-4A serine protease inhibitors: SAR of new P1 derivatives of SCH 503034.

Substitutions on the P(1) cyclobutyl side chain of SCH 503034 were studied by introduction of hydroxyl and fluoro substituents. Additionally, effects of fluoro substitution on other P1 moieties were evaluated.[1]

References

  1. Hepatitis C virus NS3-4A serine protease inhibitors: SAR of new P1 derivatives of SCH 503034. Bogen, S., Arasappan, A., Pan, W., Ruan, S., Padilla, A., Saksena, A.K., Girijavallabhan, V., Njoroge, F.G. Bioorg. Med. Chem. Lett. (2008) [Pubmed]
 
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