The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

FLUORINE     molecular fluorine

Synonyms: fluoro, Fluor, bifluoriden, Fluorine-19, Fluoruri acidi, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of FLUORINE

 

High impact information on FLUORINE

 

Chemical compound and disease context of FLUORINE

 

Biological context of FLUORINE

 

Anatomical context of FLUORINE

  • Serum samples, enameloid, dentin, ganoid/enamel, and bone were analyzed for F by either electron microprobe or wet chemistry [17].
  • It is suggested that specialized outer dental epithelial cell configurations may facilitate the incorporation of F into enameloid [17].
  • Previous work in our laboratory has shown that an IV-administered emulsion of perfluorooctylbromide, an agent known to localize in functioning macrophages in the reticuloendothelial system, can be detected in the liver and spleen by using fluorine-19 (19F) MR imaging [20].
  • These drugs, however, inhibited intracellular metabolism of the complex, as indicated by the impairment of the return of F species to the extracellular space and the increase in F content of the tissue [21].
  • The serum levels of ionic F (the mitogenic species on osteoblasts) were not related to the above mentioned effects [22].
 

Associations of FLUORINE with other chemical compounds

 

Gene context of FLUORINE

  • The present results show that appropriate fluorine-19 probes in the acyl chains of phospholipids can be used to investigate the structure and dynamics of model and biological membranes [28].
  • Energetics of the equilibrium between two nucleotide-free myosin subfragment 1 states using fluorine-19 nuclear magnetic resonance [29].
  • Fluorine-19 nuclear magnetic resonance study of fluorotyrosine alkaline phosphatase: the influence of zinc on protein structure and a conformational change induced by phosphate binding [30].
  • Relation between structure and specificity of antibodies: nuclear magnetic resonance study of binding fluorine-19 labeled nitrophenyl haptens to myeloma immunoglobulins M315, M460, and X25 [31].
  • To test the model, 2'-deoxy-5-fluorouracil was used to place the fluorine-19 nuclear spin-label on the side of the DNA contacting the cro repressor and on the opposite side facing away from the cro repressor [32].
 

Analytical, diagnostic and therapeutic context of FLUORINE

References

  1. Fluorine-19 nuclear magnetic resonance studies of Escherichia coli membranes. Gent, M.P., Cottam, P.F., Ho, C. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
  2. Validation of the fluorinated 2-nitroimidazole SR-4554 as a noninvasive hypoxia marker detected by magnetic resonance spectroscopy. Seddon, B.M., Maxwell, R.J., Honess, D.J., Grimshaw, R., Raynaud, F., Tozer, G.M., Workman, P. Clin. Cancer Res. (2002) [Pubmed]
  3. Fluorine-19 nuclear magnetic resonance studies of lipid fatty acyl chain order and dynamics in Acholeplasma laidlawii B membranes. A physical, biochemical, and biological evaluation of monofluoropalmitic acids as membrane probes. McDonough, B., Macdonald, P.M., Sykes, B.D., McElhaney, R.N. Biochemistry (1983) [Pubmed]
  4. A comparative toxicological investigation of perfluorocarboxylic acids in rats by fluorine-19 NMR spectroscopy. Goecke, C.M., Jarnot, B.M., Reo, N.V. Chem. Res. Toxicol. (1992) [Pubmed]
  5. Rapid tissue oxygen tension mapping using 19F inversion-recovery echo-planar imaging of perfluoro-15-crown-5-ether. Dardzinski, B.J., Sotak, C.H. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. (1994) [Pubmed]
  6. Association of intratumoral pharmacokinetics of fluorouracil with clinical response. Presant, C.A., Wolf, W., Waluch, V., Wiseman, C., Kennedy, P., Blayney, D., Brechner, R.R. Lancet (1994) [Pubmed]
  7. A proton and fluorine-19 nuclear magnetic resonance and fluorescence study of the binding of some natural and synthetic thyromimetics to prealbumin (transthyretin). Reid, D.G., MacLachlan, L.K., Voyle, M., Leeson, P.D. J. Biol. Chem. (1989) [Pubmed]
  8. Inducer and anti-inducer interactions with the lac repressor seen by nuclear magnetic resonance changes at tyrosines and tryptophans. Boschelli, F., Jarema, M.A., Lu, P. J. Biol. Chem. (1981) [Pubmed]
  9. A comparison of brain and serum pharmacokinetics of R-fluoxetine and racemic fluoxetine: A 19-F MRS study. Henry, M.E., Schmidt, M.E., Hennen, J., Villafuerte, R.A., Butman, M.L., Tran, P., Kerner, L.T., Cohen, B., Renshaw, P.F. Neuropsychopharmacology (2005) [Pubmed]
  10. Fluorine-19 NMR studies of glucosyl fluoride transport in human erythrocytes. London, R.E., Gabel, S.A. Biophys. J. (1995) [Pubmed]
  11. Recognition of Escherichia coli valine transfer RNA by its cognate synthetase: a fluorine-19 NMR study. Chu, W.C., Horowitz, J. Biochemistry (1991) [Pubmed]
  12. Site-specific incorporation of 5-fluorotryptophan as a probe of the structure and function of the membrane-bound D-lactate dehydrogenase of Escherichia coli: a 19F nuclear magnetic resonance study. Peersen, O.B., Pratt, E.A., Truong, H.T., Ho, C., Rule, G.S. Biochemistry (1990) [Pubmed]
  13. Current aspects of trace element research in environmental health. Kono, K., Yoshida, Y. Bulletin of the Osaka Medical College. (1989) [Pubmed]
  14. Biochemical and morphological properties of membranes of unsaturated fatty acid auxotrophs of Salmonella typhimurium: effects of fluorinated myristic acids. Cottam, P.F., He, N.B., Hui, S.W., Ho, C. Biochim. Biophys. Acta (1986) [Pubmed]
  15. Nuclear magnetic resonance and molecular genetic studies of the membrane-bound D-lactate dehydrogenase of Escherichia coli. Rule, G.S., Pratt, E.A., Simplaceanu, V., Ho, C. Biochemistry (1987) [Pubmed]
  16. Determination of membrane potential and cell volume by 19F NMR using trifluoroacetate and trifluoroacetamide probes. London, R.E., Gabel, S.A. Biochemistry (1989) [Pubmed]
  17. Serum fluoride level and fluoride content of enameloid. Prostak, K.S., Seifert, P., Skobe, Z. J. Dent. Res. (1991) [Pubmed]
  18. Thymidylate synthetase: fluorine-19 nmr characterization of the active site peptide covalently bound to 5-fluoro-2'-deoxyuridylate and 5,10-methylenetetrahydrofolate. James, T.L., Pogolotti, A.L., Ivanetich, K.M., Wataya, Y., Lam, S.S., Santi, D.V. Biochem. Biophys. Res. Commun. (1976) [Pubmed]
  19. Transcorneal oxygenation of the preretinal vitreous. Wilson, C.A., Benner, J.D., Berkowitz, B.A., Chapman, C.B., Peshock, R.M. Arch. Ophthalmol. (1994) [Pubmed]
  20. Detection of acute radiation damage to the spleen in mice by using fluorine-19 MR imaging. Ratner, A.V., Muller, H.H., Bradley-Simpson, B., Hirst, D., Pitts, W., Young, S.W. AJR. American journal of roentgenology. (1988) [Pubmed]
  21. Metabolism of the complex monofluorophosphate-alpha 2-macroglobulin in the rat. Esteban, L., Rigalli, A., Puche, R.C. Medicina (B Aires) (1999) [Pubmed]
  22. In postmenopausal osteoporosis the bone increasing effect of monofluorophosphate is not dependent on serum fluoride. Rigalli, A., Pera, L., Morosano, M., Masoni, A., Bocanera, R., Tozzini, R., Puche, R.C. Medicina (B Aires) (1999) [Pubmed]
  23. Oxygen kinetics in the vitreous substitute perfluorotributylamine: a 19F NMR study in vivo. Berkowitz, B.A., Wilson, C.A., Hatchell, D.L. Invest. Ophthalmol. Vis. Sci. (1991) [Pubmed]
  24. Human eye: visualization of perfluorodecalin with F-19 MR imaging. Gewiese, B.K., Noske, W., Schilling, A.M., Stiller, D.A., Wolf, K.J., Foerster, M.H. Radiology. (1992) [Pubmed]
  25. Phosphorus-31 and fluorine-19 nuclear magnetic resonance of gene 5 protein-oligonucleotide complexes. O'Connor, T.P., Coleman, J.E. Biochemistry (1982) [Pubmed]
  26. F-19 MR imaging of glucose metabolism in the rabbit. Nakada, T., Kwee, I.L., Griffey, B.V., Griffey, R.H. Radiology. (1988) [Pubmed]
  27. Isomerization of (3S)-2,3-dihydro-5-fluoro-L-tryptophan and of 5-fluoro-L-tryptophan catalyzed by tryptophan synthase: studies using fluorine-19 nuclear magnetic resonance and difference spectroscopy. Miles, E.W., Phillips, R.S., Yeh, H.J., Cohen, L.A. Biochemistry (1986) [Pubmed]
  28. Nuclear magnetic resonance line-shape analysis of fluorine-19-labeled phospholipids. Engelsberg, M., Dowd, S.R., Simplaceanu, V., Cook, B.W., Ho, C. Biochemistry (1982) [Pubmed]
  29. Energetics of the equilibrium between two nucleotide-free myosin subfragment 1 states using fluorine-19 nuclear magnetic resonance. Shriver, J.W., Sykes, B.D. Biochemistry (1982) [Pubmed]
  30. Fluorine-19 nuclear magnetic resonance study of fluorotyrosine alkaline phosphatase: the influence of zinc on protein structure and a conformational change induced by phosphate binding. Hull, W.E., Sykes, B.D. Biochemistry (1976) [Pubmed]
  31. Relation between structure and specificity of antibodies: nuclear magnetic resonance study of binding fluorine-19 labeled nitrophenyl haptens to myeloma immunoglobulins M315, M460, and X25. Hardy, R.R., Richards, J.H. Biochemistry (1978) [Pubmed]
  32. Lambda phage cro repressor interaction with its operator DNA: 2'-deoxy-5-fluorouracil OR3 analogues. Metzler, W.J., Arndt, K., Tecza, E., Wasilewski, J., Lu, P. Biochemistry (1985) [Pubmed]
  33. Tumor oximetry: demonstration of an enhanced dynamic mapping procedure using fluorine-19 echo planar magnetic resonance imaging in the Dunning prostate R3327-AT1 rat tumor. Hunjan, S., Zhao, D., Constantinescu, A., Hahn, E.W., Antich, P.P., Mason, R.P. Int. J. Radiat. Oncol. Biol. Phys. (2001) [Pubmed]
  34. Gel-entrapment of perfluorocarbons: a fluorine-19 NMR spectroscopic method for monitoring oxygen concentration in cell perfusion systems. McGovern, K.A., Schoeniger, J.S., Wehrle, J.P., Ng, C.E., Glickson, J.D. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. (1993) [Pubmed]
  35. Fluorine-19 nuclear magnetic resonance imaging and spectroscopy of sevoflurane uptake, distribution, and elimination in rat brain. Xu, Y., Tang, P., Zhang, W., Firestone, L., Winter, P.M. Anesthesiology (1995) [Pubmed]
  36. Human urinary excretion of doxifluridine and metabolites during a 5-day chemotherapeutic schedule using fluorine-19 nuclear magnetic resonance spectrometry. Malet-Martino, M.C., Servin, P., Bernadou, J., Armand, J.P., Martino, R. Investigational new drugs. (1987) [Pubmed]
  37. Noninvasive fluorine-19 NMR study of fluoropyrimidine metabolism in cell cultures of human pancreatic and colon adenocarcinoma. Malet-Martino, M.C., Faure, F., Vialaneix, J.P., Palevody, C., Hollande, E., Martino, R. Cancer Chemother. Pharmacol. (1986) [Pubmed]
 
WikiGenes - Universities