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MeSH Review:

Hepacivirus

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Disease relevance of Hepacivirus

Ongoing research has identified possible targets for inhibition, including binding of the virus to the cell, uptake of the virus into the cell, the internal ribosome entry site of hepaciviruses and pestiviruses, the capping mechanism of flaviviruses, the viral proteases, the viral RNA-dependent RNA polymerase, and the viral helicase [1].
The potential of BPIP for the treatment of pestivirus and hepacivirus infections is discussed [2].
Hepatitis C virus (HCV) is classified in the genus Hepacivirus of the family Flaviviridae, whose members have a single-stranded RNA genome of positive polarity, which encodes a single polyprotein [3].

High impact information on Hepacivirus

Interaction of poly(rC)-binding protein 2 with the 5'-terminal stem loop of the hepatitis C-virus genome [4].
BACKGROUND: Recent trials have shown that treatment with a combination of interferon alfa-2b and ribavirin results in sustained loss of detectable hepatitis C-virus (HCV) RNA in a higher proportion of patients than treatment with interferon alone [5].

References

Perspectives for the treatment of infections with Flaviviridae. Leyssen, P., De Clercq, E., Neyts, J. Clin. Microbiol. Rev. (2000) [Pubmed]
A novel, highly selective inhibitor of pestivirus replication that targets the viral RNA-dependent RNA polymerase. Paeshuyse, J., Leyssen, P., Mabery, E., Boddeker, N., Vrancken, R., Froeyen, M., Ansari, I.H., Dutartre, H., Rozenski, J., Gil, L.H., Letellier, C., Lanford, R., Canard, B., Koenen, F., Kerkhofs, P., Donis, R.O., Herdewijn, P., Watson, J., De Clercq, E., Puerstinger, G., Neyts, J. J. Virol. (2006) [Pubmed]
Analysis of hepatitis C virus/classical swine fever virus chimeric 5'NTRs: sequences within the hepatitis C virus IRES are required for viral RNA replication. Reusken, C.B., Dalebout, T.J., Eerligh, P., Bredenbeek, P.J., Spaan, W.J. J. Gen. Virol. (2003) [Pubmed]
Interaction of poly(rC)-binding protein 2 with the 5'-terminal stem loop of the hepatitis C-virus genome. Fukushi, S., Okada, M., Kageyama, T., Hoshino, F.B., Nagai, K., Katayama, K. Virus Res. (2001) [Pubmed]
Cost-effectiveness of interferon alfa-2b with and without ribavirin as therapy for chronic hepatitis C in Sweden. Sennfält, K., Reichard, O., Hultkrantz, R., Wong, J.B., Jonsson, D. Scand. J. Gastroenterol. (2001) [Pubmed]

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