The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Hepacivirus

  • Ongoing research has identified possible targets for inhibition, including binding of the virus to the cell, uptake of the virus into the cell, the internal ribosome entry site of hepaciviruses and pestiviruses, the capping mechanism of flaviviruses, the viral proteases, the viral RNA-dependent RNA polymerase, and the viral helicase [1].
  • The potential of BPIP for the treatment of pestivirus and hepacivirus infections is discussed [2].
  • Hepatitis C virus (HCV) is classified in the genus Hepacivirus of the family Flaviviridae, whose members have a single-stranded RNA genome of positive polarity, which encodes a single polyprotein [3].

High impact information on Hepacivirus


  1. Perspectives for the treatment of infections with Flaviviridae. Leyssen, P., De Clercq, E., Neyts, J. Clin. Microbiol. Rev. (2000) [Pubmed]
  2. A novel, highly selective inhibitor of pestivirus replication that targets the viral RNA-dependent RNA polymerase. Paeshuyse, J., Leyssen, P., Mabery, E., Boddeker, N., Vrancken, R., Froeyen, M., Ansari, I.H., Dutartre, H., Rozenski, J., Gil, L.H., Letellier, C., Lanford, R., Canard, B., Koenen, F., Kerkhofs, P., Donis, R.O., Herdewijn, P., Watson, J., De Clercq, E., Puerstinger, G., Neyts, J. J. Virol. (2006) [Pubmed]
  3. Analysis of hepatitis C virus/classical swine fever virus chimeric 5'NTRs: sequences within the hepatitis C virus IRES are required for viral RNA replication. Reusken, C.B., Dalebout, T.J., Eerligh, P., Bredenbeek, P.J., Spaan, W.J. J. Gen. Virol. (2003) [Pubmed]
  4. Interaction of poly(rC)-binding protein 2 with the 5'-terminal stem loop of the hepatitis C-virus genome. Fukushi, S., Okada, M., Kageyama, T., Hoshino, F.B., Nagai, K., Katayama, K. Virus Res. (2001) [Pubmed]
  5. Cost-effectiveness of interferon alfa-2b with and without ribavirin as therapy for chronic hepatitis C in Sweden. Sennfält, K., Reichard, O., Hultkrantz, R., Wong, J.B., Jonsson, D. Scand. J. Gastroenterol. (2001) [Pubmed]
WikiGenes - Universities