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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Danese, S.

S. Danese,

Mechanisms of action of infliximab in inflammatory bowel disease: an anti-inflammatory multitasker.

The pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) plays a central role in mucosal inflammation and is a key mediator in the inflammatory cascade in both Crohn's disease (CD) and ulcerative colitis (UC). Infliximab, a monoclonal antibody against TNF-alpha has been proved highly effective in the clinical management of both forms of IBD. Aim of this paper is to review the mechanisms of action of infliximab in IBD.[1]

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Mechanisms of action of infliximab in inflammatory bowel disease: an anti-inflammatory multitasker. Danese, S. Dig. Liver. Dis (2008) [Pubmed]

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