Anticataractogenic property of gamma-glutamylcysteine ethyl ester in an animal model of cataract.
The anticataractogenic potential of gamma-glutamylcysteine ethyl ester was investigated in model cataracts induced by L-buthionine sulfoximine. Subcutaneous injection of the ester (0.625-2.5 mmol/kg) effectively inhibited cataractogenesis in suckling mice. Treatment of mice with L-buthionine sulfoximine alone resulted in a marked reduction of the glutathione content in the eyes. This deprivation of glutathione was mitigated, to a significant degree, by coadministering gamma-glutamylcysteine ethyl ester. In an experiment with rat lens in culture, gamma-glutamylcysteine ethyl ester was found to elevate the lenticular level of glutathione. These results indicate that gamma-glutamylcysteine ethyl ester is able to permeate across biomembranes and serves as an excellent precursor for glutathione biosynthesis, thereby exerting its anticataractogenic activity.[1]References
- Anticataractogenic property of gamma-glutamylcysteine ethyl ester in an animal model of cataract. Ohtsu, A., Kitahara, S., Fujii, K. Ophthalmic Res. (1991) [Pubmed]
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