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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Isolation of a cathepsin B-encoding cDNA from murine osteogenic cells.

Cathepsin B-encoding cDNA (CTSB) clones have been isolated from a lambda gt10 library of a murine osteosarcoma by differential screening during a search for genes which are typically expressed during osteogenic differentiation in mouse mandibular condyles in vitro. Sequencing of the CTSB 3' end revealed that the isolated sequence contained an 825-bp 3'-noncoding region, the polyadenylation signal and the poly(A) tail. The enhanced CTSB expression during the early stages of the enchondral ossification-like process in mandibular condyles in vitro suggests that CTSB participates in the degradation of cartilage matrix prior to the synthesis of bone matrix proteins.[1]


  1. Isolation of a cathepsin B-encoding cDNA from murine osteogenic cells. Freimert, C., Closs, E.I., Silbermann, M., Erfle, V., Strauss, P.G. Gene (1991) [Pubmed]
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