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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Richard, J.P.

John P. Richard,

Restoring a metabolic pathway.

Gluconeogenesis is blocked in a strain of Escherichia coli that is deficient in triosephosphate isomerase, but it was restored by the insertion of a plasmid coding for an L-glyceraldehyde 3-phosphate reductase (YghZ). This reductase provides a "bypass" that produces dihydroxyacetone phosphate (DHAP) by the consecutive enzyme-catalyzed reduction of L-glyceraldehyde 3-phosphate ( L-GAP) by NADPH to give L-glycerol 3-phosphate and reoxidation by NAD(+) catalyzed by endogenous L-glycerol 3-phosphate dehydrogenase to give DHAP. The origin of cellular L-GAP remains to be determined.[1]

References

Restoring a metabolic pathway. Richard, J.P. ACS Chem. Biol. (2008) [Pubmed]

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