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Gene Review

gpr  -  L-glyceraldehyde 3-phosphate reductase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2995, JW2970, mgrA, yghZ
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Disease relevance of yghZ


High impact information on yghZ


Biological context of yghZ

  • Two cDNAs encoding leaf-specific AKR proteins (DpAR1 and DpAR2) were isolated from a D. purpurea cDNA library using the rat Delta4-3-ketosteroid 5beta-reductase clone [9].
  • The deduced amino acid sequences of the two enzymes showed high similarity to each other and to several proteins of the aldo-keto reductase (AKR) superfamily [10].

Associations of yghZ with chemical compounds


  1. A novel aldo-keto reductase from Escherichia coli can increase resistance to methylglyoxal toxicity. Grant, A.W., Steel, G., Waugh, H., Ellis, E.M. FEMS Microbiol. Lett. (2003) [Pubmed]
  2. Molecular cloning, expression, and properties of an unusual aldo-keto reductase family enzyme, pyridoxal 4-dehydrogenase, that catalyzes irreversible oxidation of pyridoxal. Yokochi, N., Yoshikane, Y., Trongpanich, Y., Ohnishi, K., Yagi, T. J. Biol. Chem. (2004) [Pubmed]
  3. A new member of the aldo-keto reductase family from the plant pathogen Xylella fastidiosa. Rosselli, L.K., Oliveira, C.L., Azzoni, A.R., Tada, S.F., Catani, C.F., Saraiva, A.M., Soares, J.S., Medrano, F.J., Torriani, I.L., Souza, A.P. Arch. Biochem. Biophys. (2006) [Pubmed]
  4. Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members. O'connor, T., Ireland, L.S., Harrison, D.J., Hayes, J.D. Biochem. J. (1999) [Pubmed]
  5. Reversion of the tyrosine ochre strain Escherichia coli WU3610 under starvation conditions depends on a new gene tas. Timms, A.R., Bridges, B.A. Genetics (1998) [Pubmed]
  6. Mutagenesis of 3 alpha-hydroxysteroid dehydrogenase reveals a "push-pull" mechanism for proton transfer in aldo-keto reductases. Schlegel, B.P., Jez, J.M., Penning, T.M. Biochemistry (1998) [Pubmed]
  7. An anion binding site in human aldose reductase: mechanistic implications for the binding of citrate, cacodylate, and glucose 6-phosphate. Harrison, D.H., Bohren, K.M., Ringe, D., Petsko, G.A., Gabbay, K.H. Biochemistry (1994) [Pubmed]
  8. Characterization of ovarian carbonyl reductase gene expression during ovulation in the gonadotropin-primed immature Rat. Espey, L.L., Yoshioka, S., Russell, D., Ujioka, T., Vladu, B., Skelsey, M., Fujii, S., Okamura, H., Richards, J.S. Biol. Reprod. (2000) [Pubmed]
  9. Cloning and expression of two novel aldo-keto reductases from Digitalis purpurea leaves. Gavidia, I., Pérez-Bermúdez, P., Seitz, H.U. Eur. J. Biochem. (2002) [Pubmed]
  10. Gene cloning and overexpression of two conjugated polyketone reductases, novel aldo-keto reductase family enzymes, of Candida parapsilosis. Kataoka, M., Delacruz-Hidalgo, A.R., Akond, M.A., Sakuradani, E., Kita, K., Shimizu, S. Appl. Microbiol. Biotechnol. (2004) [Pubmed]
  11. Purification and characterization of NADPH-dependent aldo-keto reductase specific for beta-keto esters from Penicillium citrinum, and production of methyl (S)-4-bromo-3-hydroxybutyrate. Itoh, N., Asako, H., Banno, K., Makino, Y., Shinohara, M., Dairi, T., Wakita, R., Shimizu, M. Appl. Microbiol. Biotechnol. (2004) [Pubmed]
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