Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Tang, Y. et al.

A thermosensitive chitosan/poly(vinyl alcohol) hydrogel containing hydroxyapatite for protein delivery.

The synthesis and characterization of a thermosensitive chitosan/poly(vinyl alcohol) (PVA) hydrogel containing hydroxyapatite for protein delivery were first reported. Two synthetic processes were introduced, that is, in situ and ex situ routes. Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and rheological analysis were employed to characterize the hydrogel. The gel formation decreased the crystallinity of the hydroxyapatite crystal. FTIR results showed that the hydroxyapatite crystals were partially substituted by carbonate. It was supposed that the structural features of hydroxyapatite were close to those of biological apatites. The thermosensitive property of the gels was evaluated by rheological analysis, which indicated that the strength of hydroxyapatite-chitosan/PVA composite gels was notably enhanced in comparison with that of pure chitosan/PVA gel, especially for hydroxyapatite-chitosan/PVA composite gels synthesized through the in situ process. The performances of composite gels containing different amounts of hydroxyapatite were further studied. For the hydroxyapatite-chitosan/PVA composite gels containing 0.1 mM hydroxyapatite synthesized through in situ process, the swelling degree was the lowest, and the speed of protein release was the slowest. Therefore, the composite gels are attractive for applications as protein delivery, artificial bones, and scaffolds for tissue engineering.[1]

References

A thermosensitive chitosan/poly(vinyl alcohol) hydrogel containing hydroxyapatite for protein delivery. Tang, Y., Du, Y., Li, Y., Wang, X., Hu, X. J. Biomed. Mater. Res. A (2009) [Pubmed]

Annotations and hyperlinks in this abstract are from individual authors of WikiGenes or automatically generated by the WikiGenes Data Mining Engine. The abstract is from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.