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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Hydrogel     2-(2-methylprop-2- enoyloxy)ethyl 2...

Synonyms: EGDMA, PEG-DMA, Ageflex EGDM, CCRIS 179, AG-J-05723, ...
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Disease relevance of Hydrogel


Psychiatry related information on Hydrogel


High impact information on Hydrogel


Chemical compound and disease context of Hydrogel


Biological context of Hydrogel


Anatomical context of Hydrogel

  • We have devised a self-assembling peptide hydrogel scaffold for cartilage repair and developed a method to encapsulate chondrocytes within the peptide hydrogel [22].
  • A macroporous hydrogel for the coculture of neural progenitor and endothelial cells to form functional vascular networks in vivo [23].
  • In rats in which the carotid artery had been severely injured by crushing, treatment with the hydrogel barrier completely eliminated thrombosis (P < 0.01) and preserved long-term patency (P < 0.01) [1].
  • We have investigated the potential of neural progenitor cells to augment the formation and stabilization of microvascular networks in a previously uncharacterized three-dimensional macroporous hydrogel and the ability of this engineered system to develop a functional microcirculation in vivo [23].
  • One day after seeding permselective synthetic guidance channels with a Schwann cell suspension, a central cable of Schwann cells oriented along the axis of the tube was formed due to syneresis of the hydrogel [24].

Associations of Hydrogel with other chemical compounds


Gene context of Hydrogel

  • The regrowth of axons within tissue defects in the CNS is promoted by implanted hydrogel matrices that contain BDNF and CNTF producing fibroblasts [30].
  • The photocrosslinkable chitosan hydrogel has a low affinity for FGF-2 (Kd = 6.12 x 10(-7) M) [31].
  • Moreover, the hair shaft length was significantly elongated by the collagen hydrogel incorporating VEGF, in marked contrast to other agents [32].
  • The values became maximum for the gelatin hydrogel incorporating BMP-2 with a middle period of BMP-2 retention, while bone formation was histologically observed around the hydrogel incorporating BMP-2 [33].
  • When BAG-1 p29 transfectants were incubated in hydrogel-coated plates, BAG-1 p29-expressing SKOV3 cells were significantly more resistant to anoikis as compared to controls, and this correlated with decreased activation of caspase-3 [34].

Analytical, diagnostic and therapeutic context of Hydrogel

  • Hollow fibers fabricated from an acrylic copolymer were used to encapsulate small numbers of rat islets that were immobilized in an alginate hydrogel for transplantation in diabetic mice [35].
  • Taken together, these results demonstrate the potential of a self-assembling peptide hydrogel as a scaffold for the synthesis and accumulation of a true cartilage-like ECM within a three-dimensional cell culture for cartilage tissue repair [22].
  • Inhibition of platelet deposition and lysis of intracoronary thrombus during balloon angioplasty using urokinase-coated hydrogel balloons [36].
  • After subcutaneous implantation of hydrogel cocultures in mice, blood flow in new microvessels was apparent at 2 weeks with perfused networks established on the surface of implants at 6 weeks [23].
  • Balloon dilatations in contralateral vessels with uncoated hydrogel balloons served as study controls [21].


  1. Inhibition of thrombosis and intimal thickening by in situ photopolymerization of thin hydrogel barriers. Hill-West, J.L., Chowdhury, S.M., Slepian, M.J., Hubbell, J.A. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  2. The therapeutic effects of basic fibroblast growth factor contained in gelatin hydrogel microspheres on experimental osteoarthritis in the rabbit knee. Inoue, A., Takahashi, K.A., Arai, Y., Tonomura, H., Sakao, K., Saito, M., Fujioka, M., Fujiwara, H., Tabata, Y., Kubo, T. Arthritis Rheum. (2006) [Pubmed]
  3. Biodegradable gelatin hydrogel potentiates the angiogenic effect of fibroblast growth factor 4 plasmid in rabbit hindlimb ischemia. Kasahara, H., Tanaka, E., Fukuyama, N., Sato, E., Sakamoto, H., Tabata, Y., Ando, K., Iseki, H., Shinozaki, Y., Kimura, K., Kuwabara, E., Koide, S., Nakazawa, H., Mori, H. J. Am. Coll. Cardiol. (2003) [Pubmed]
  4. Effect of endoscopic augmentation of the lower oesophageal sphincter (Gatekeeper reflux repair system) on intraoesophageal dynamic characteristics of acid reflux. Cicala, M., Gabbrielli, A., Emerenziani, S., Guarino, M.P., Ribolsi, M., Caviglia, R., Costamagna, G. Gut (2005) [Pubmed]
  5. Enhanced repair of the anterior cruciate ligament by in situ gene transfer: evaluation in an in vitro model. Pascher, A., Steinert, A.F., Palmer, G.D., Betz, O., Gouze, J.N., Gouze, E., Pilapil, C., Ghivizzani, S.C., Evans, C.H., Murray, M.M. Mol. Ther. (2004) [Pubmed]
  6. pH-sensitive holographic sensors. Marshall, A.J., Blyth, J., Davidson, C.A., Lowe, C.R. Anal. Chem. (2003) [Pubmed]
  7. Topical mononitrate treatment in patients with anal fissure. Tankova, L., Yoncheva, K., Muhtarov, M., Kadyan, H., Draganov, V. Aliment. Pharmacol. Ther. (2002) [Pubmed]
  8. Spoilage of hydrogel contact lenses by lipid deposits. Tear-film potassium depression, fat, protein, and alcohol consumption. Hart, D.E., Lane, B.C., Josephson, J.E., Tisdale, R.R., Gzik, M., Leahy, R., Dennis, R. Ophthalmology (1987) [Pubmed]
  9. Adherence of Pseudomonas aeruginosa to rigid gas-permeable contact lenses. Miller, M.J., Wilson, L.A., Ahearn, D.G. Arch. Ophthalmol. (1991) [Pubmed]
  10. Homotopic grafts of septal neurons combined to polymeric hydrogels placed into a fimbria-fornix lesion cavity attenuate locomotor hyperactivity but not mnemonic dysfunctions in rats. Duconseille, E., Carrot, S.N., Woerly, S., Kelche, C., Will, B., Cassel, J.C. Restorative neurology and neuroscience. (2001) [Pubmed]
  11. Hybrid hydrogels assembled from synthetic polymers and coiled-coil protein domains. Wang, C., Stewart, R.J., Kopecek, J. Nature (1999) [Pubmed]
  12. A synthetic mimic of the secretory granule for drug delivery. Kiser, P.F., Wilson, G., Needham, D. Nature (1998) [Pubmed]
  13. Nerve fiber growth on defined hydrogel substrates. Carbonetto, S.T., Gruver, M.M., Turner, D.C. Science (1982) [Pubmed]
  14. Clinical evidence of angiogenesis after arterial gene transfer of phVEGF165 in patient with ischaemic limb. Isner, J.M., Pieczek, A., Schainfeld, R., Blair, R., Haley, L., Asahara, T., Rosenfield, K., Razvi, S., Walsh, K., Symes, J.F. Lancet (1996) [Pubmed]
  15. Inhibition of platelet-dependent thrombosis by local delivery of heparin with a hydrogel-coated balloon. Nunes, G.L., Thomas, C.N., Hanson, S.R., Barry, J.J., King, S.B., Scott, N.A. Circulation (1995) [Pubmed]
  16. In vivo study of bacterial adhesion to five types of intraocular lenses. Kodjikian, L., Burillon, C., Chanloy, C., Bostvironnois, V., Pellon, G., Mari, E., Freney, J., Roger, T. Invest. Ophthalmol. Vis. Sci. (2002) [Pubmed]
  17. Antibiotic hydrogel coated Foley catheters for prevention of urinary tract infection in a rabbit model. Pugach, J.L., DiTizio, V., Mittelman, M.W., Bruce, A.W., DiCosmo, F., Khoury, A.E. J. Urol. (1999) [Pubmed]
  18. Preparation and in vitro/in vivo evaluation of insulin-loaded poly(acryloyl-hydroxyethyl starch)-PLGA composite microspheres. Jiang, G., Qiu, W., DeLuca, P.P. Pharm. Res. (2003) [Pubmed]
  19. Povidone-iodine in polyethylene oxide hydrogel dressing. Effect on multiplication of Staphylococcus aureus in partial-thickness wounds. Mertz, P.M., Marshall, D.A., Kuglar, M.A. Archives of dermatology. (1986) [Pubmed]
  20. Synthetic matrix metalloproteinase-sensitive hydrogels for the conduction of tissue regeneration: engineering cell-invasion characteristics. Lutolf, M.P., Lauer-Fields, J.L., Schmoekel, H.G., Metters, A.T., Weber, F.E., Fields, G.B., Hubbell, J.A. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  21. Decreased platelet deposition and smooth muscle cell proliferation after intramural heparin delivery with hydrogel-coated balloons. Azrin, M.A., Mitchel, J.F., Fram, D.B., Pedersen, C.A., Cartun, R.W., Barry, J.J., Bow, L.M., Waters, D.D., McKay, R.G. Circulation (1994) [Pubmed]
  22. Self-assembling peptide hydrogel fosters chondrocyte extracellular matrix production and cell division: implications for cartilage tissue repair. Kisiday, J., Jin, M., Kurz, B., Hung, H., Semino, C., Zhang, S., Grodzinsky, A.J. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  23. A macroporous hydrogel for the coculture of neural progenitor and endothelial cells to form functional vascular networks in vivo. Ford, M.C., Bertram, J.P., Hynes, S.R., Michaud, M., Li, Q., Young, M., Segal, S.S., Madri, J.A., Lavik, E.B. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  24. Syngeneic Schwann cells derived from adult nerves seeded in semipermeable guidance channels enhance peripheral nerve regeneration. Guénard, V., Kleitman, N., Morrissey, T.K., Bunge, R.P., Aebischer, P. J. Neurosci. (1992) [Pubmed]
  25. Regeneration of defects in articular cartilage in rat knee joints by CCN2 (connective tissue growth factor). Nishida, T., Kubota, S., Kojima, S., Kuboki, T., Nakao, K., Kushibiki, T., Tabata, Y., Takigawa, M. J. Bone Miner. Res. (2004) [Pubmed]
  26. Glucose recovery with bare and hydrogel-coated microdialysis probes: experiment and simulation of temporal effects. Norton, L.W., Yuan, F., Reichert, W.M. Anal. Chem. (2007) [Pubmed]
  27. Topographical thickness of the epithelium and total cornea after hydrogel and PMMA contact lens wear with eye closure. Wang, J., Fonn, D., Simpson, T.L. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  28. Quantitation of slow drug release from an implantable and degradable gentamicin conjugate by in vivo magnetic resonance imaging. Weissleder, R., Poss, K., Wilkinson, R., Zhou, C., Bogdanov, A. Antimicrob. Agents Chemother. (1995) [Pubmed]
  29. A thermosensitive hydrogel based on quaternized chitosan and poly(ethylene glycol) for nasal drug delivery system. Wu, J., Wei, W., Wang, L.Y., Su, Z.G., Ma, G.H. Biomaterials (2007) [Pubmed]
  30. The regrowth of axons within tissue defects in the CNS is promoted by implanted hydrogel matrices that contain BDNF and CNTF producing fibroblasts. Loh, N.K., Woerly, S., Bunt, S.M., Wilton, S.D., Harvey, A.R. Exp. Neurol. (2001) [Pubmed]
  31. The interaction of chitosan with fibroblast growth factor-2 and its protection from inactivation. Masuoka, K., Ishihara, M., Asazuma, T., Hattori, H., Matsui, T., Takase, B., Kanatani, Y., Fujita, M., Saito, Y., Yura, H., Fujikawa, K., Nemoto, K. Biomaterials (2005) [Pubmed]
  32. Promoted growth of murine hair follicles through controlled release of vascular endothelial growth factor. Ozeki, M., Tabata, Y. Biomaterials (2002) [Pubmed]
  33. Controlled release by biodegradable hydrogels enhances the ectopic bone formation of bone morphogenetic protein. Yamamoto, M., Takahashi, Y., Tabata, Y. Biomaterials (2003) [Pubmed]
  34. BAG-1 p29 protein prevents drug-induced cell death in the presence of EGF and enhances resistance to anoikis in SKOV3 human ovarian cancer cells. Pagé, V., Côté, M., Rancourt, C., Sullivan, M., Piché, A. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  35. Maintenance of normoglycemia in diabetic mice by subcutaneous xenografts of encapsulated islets. Lacy, P.E., Hegre, O.D., Gerasimidi-Vazeou, A., Gentile, F.T., Dionne, K.E. Science (1991) [Pubmed]
  36. Inhibition of platelet deposition and lysis of intracoronary thrombus during balloon angioplasty using urokinase-coated hydrogel balloons. Mitchel, J.F., Azrin, M.A., Fram, D.B., Hong, M.K., Wong, S.C., Barry, J.J., Bow, L.M., Curley, T.M., Kiernan, F.J., Waters, D.D. Circulation (1994) [Pubmed]
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