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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Type IV allergy to amide-type local anesthetics.

The case of a 45-year-old woman is reported, who developed intense erythema and itching 1 day after subcutaneous (s.c.) injection of a local anesthetic containing mepivacaine and methylparaben. The reaction was attributed to a delayed-type sensitivity to mepivacaine, since mepivacaine gave a positive patch test response and also elicited a delayed sensitivity reaction after s.c. challenges, whereas prick and patch tests with methylparaben, as well as oral challenges, were negative. Interestingly, the patient also showed sensitization to lidocaine, a compound to which she had previously also been exposed.[1]


  1. Type IV allergy to amide-type local anesthetics. Klein, C.E., Gall, H. Contact Derm. (1991) [Pubmed]
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