The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Patch Tests

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Patch Tests


High impact information on Patch Tests


Chemical compound and disease context of Patch Tests


Biological context of Patch Tests


Anatomical context of Patch Tests


Associations of Patch Tests with chemical compounds

  • Special studies indicated a high titer quinidine-dependent IgG antibody level in the patient's serum and a strongly positive quinidine patch test result on his forearm [25].
  • In contrast, the percentages of CLA+ T cells in the lesional skin of patients with AD, in the APT reactions, and in sodium lauryl sulfate and nickel patch test reactions were decreased [20].
  • METHODS: An ethanol patch test on the upper arm and a questionnaire survey addressing the past history of alcohol-induced asthma were administered to 148 adult Japanese asthmatic subjects [15].
  • The successful completion of a test is indicated by a fill tab, which changes color when the appropriate amount of sweat has been picked up by the chloride test patch [26].
  • In many cases a positive routine patch test to thiomersal should be considered an accidental finding without or, probably more accurately, with low clinical relevance [27].

Gene context of Patch Tests

  • CD biopsies were taken from 10 positive skin patch test sites and iNOS immunoreactivity was detected in all of these. iNOS immunoreactivity was detected in only one of the negative patch test biopsies [28].
  • OBJECTIVE: To study the expression of CS-1 fibronectin, TARC and Th1-associated chemokine receptors in biopsies from allergic patch test reactions [29].
  • In contrast, ICAM-1 is already expressed in higher levels in normal skin and is hardly enhanced during the first 8 h of patch test reactions [30].
  • In this group, biopsies from positive atopic allergen patch tests showed an enhanced density of fibers labeled by antibody to Neuron-specific protein 9.5 and a lower density in labeling for Tyrosine hydroxylase [31].
  • In 48-h inhalant allergen patch test reactions, however, IFN-gamma mRNA and IL-2 mRNA expression were increased above levels observed in control skin, whereas IL-4 mRNA expression was decreased below background levels [17].

Analytical, diagnostic and therapeutic context of Patch Tests


  1. Basophils in allergen-induced patch test sites in atopic dermatitis. Mitchell, E.B., Crow, J., Chapman, M.D., Jouhal, S.S., Pope, F.M., Platts-Mills, T.A. Lancet (1982) [Pubmed]
  2. Absence of T-regulatory cell expression and function in atopic dermatitis skin. Verhagen, J., Akdis, M., Traidl-Hoffmann, C., Schmid-Grendelmeier, P., Hijnen, D., Knol, E.F., Behrendt, H., Blaser, K., Akdis, C.A. J. Allergy Clin. Immunol. (2006) [Pubmed]
  3. Mexiletine-induced severe skin eruption, fever, eosinophilia, atypical lymphocytosis, and liver dysfunction. Higa, K., Hirata, K., Dan, K. Pain (1997) [Pubmed]
  4. Topical cyclosporin A in nickel contact hypersensitivity: results of a preliminary clinical and immunohistochemical investigation. Aldridge, R.D., Sewell, H.F., King, G., Thomson, A.W. Clin. Exp. Immunol. (1986) [Pubmed]
  5. Hydrocortisone sensitivity: clinical features of fifty-nine cases. Wilkinson, S.M., English, J.S. J. Am. Acad. Dermatol. (1992) [Pubmed]
  6. Nickel and molybdenum contact allergies in patients with coronary in-stent restenosis. Köster, R., Vieluf, D., Kiehn, M., Sommerauer, M., Kähler, J., Baldus, S., Meinertz, T., Hamm, C.W. Lancet (2000) [Pubmed]
  7. Ethanol patch test for low Km aldehyde dehydrogenase deficiency. Higuchi, S., Muramatsu, T., Saito, M., Sasao, M., Maruyama, K., Kono, H., Niimi, Y. Lancet (1987) [Pubmed]
  8. Beryllium skin patch testing to analyze T cell stimulation and granulomatous inflammation in the lung. Fontenot, A.P., Maier, L.A., Canavera, S.J., Hendry-Hofer, T.B., Boguniewicz, M., Barker, E.A., Newman, L.S., Kotzin, B.L. J. Immunol. (2002) [Pubmed]
  9. Engagement of the Fc epsilon RI stimulates the production of IL-16 in Langerhans cell-like dendritic cells. Reich, K., Heine, A., Hugo, S., Blaschke, V., Middel, P., Kaser, A., Tilg, H., Blaschke, S., Gutgesell, C., Neumann, C. J. Immunol. (2001) [Pubmed]
  10. Bulbar conjunctival follicles associated with dipivefrin therapy. Liesegang, T.J. Ophthalmology (1985) [Pubmed]
  11. Skin susceptibility in uninvolved skin of hand eczema patients and healthy controls. Agner, T. Br. J. Dermatol. (1991) [Pubmed]
  12. Pustular patch test reactions in atopic dermatitis. Uehara, M., Takahashi, C., Ofuji, S. Archives of dermatology. (1975) [Pubmed]
  13. Ocular inflammation in patients using soft contact lenses. Rietschel, R.L., Wilson, L.A. Archives of dermatology. (1982) [Pubmed]
  14. Delayed hypersensitivity to topical corticosteroids. Reitamo, S., Lauerma, A.I., Stubb, S., Käyhkö, K., Visa, K., Förström, L. J. Am. Acad. Dermatol. (1986) [Pubmed]
  15. Screening for acetaldehyde dehydrogenase 2 genotype in alcohol-induced asthma by using the ethanol patch test. Matsuse, H., Shimoda, T., Fukushima, C., Mitsuta, K., Kawano, T., Tomari, S., Saeki, S., Kondoh, Y., Machida, I., Obase, Y., Asai, S., Kohno, S. J. Allergy Clin. Immunol. (2001) [Pubmed]
  16. Topical mometasone. A review of its pharmacological properties and therapeutic use in the treatment of dermatological disorders. Prakash, A., Benfield, P. Drugs (1998) [Pubmed]
  17. Analysis of the cytokine pattern expressed in situ in inhalant allergen patch test reactions of atopic dermatitis patients. Grewe, M., Walther, S., Gyufko, K., Czech, W., Schöpf, E., Krutmann, J. J. Invest. Dermatol. (1995) [Pubmed]
  18. Balsam-related systemic contact dermatitis. Salam, T.N., Fowler, J.F. J. Am. Acad. Dermatol. (2001) [Pubmed]
  19. Ethanol patch test: a simple method for identifying the effectiveness of cyanamide in alcoholics. Yamauchi, M., Kimura, T., Takeda, K., Sakamoto, K., Ohata, M., Tabe, T., Nakano, K., Fujiwara, S., Takao, Y., Toda, G. Alcohol. Clin. Exp. Res. (2000) [Pubmed]
  20. Nonspecific T-cell homing during inflammation in atopic dermatitis: expression of cutaneous lymphocyte-associated antigen and integrin alphaE beta7 on skin-infiltrating T cells. de Vries, I.J., Langeveld-Wildschut, E.G., van Reijsen, F.C., Bihari, I.C., Bruijnzeel-Koomen, C.A., Thepen, T. J. Allergy Clin. Immunol. (1997) [Pubmed]
  21. Determination of interleukin-5 secretion from drug-specific activated ex vivo peripheral blood mononuclear cells as a test system for the in vitro detection of drug sensitization. Sachs, B., Erdmann, S., Malte Baron, J., Neis, M., al Masaoudi, T., Merk, H.F. Clin. Exp. Allergy (2002) [Pubmed]
  22. Expression of Fc receptors for IgG during acute and chronic cutaneous inflammation in atopic dermatitis. Kiekens, R.C., Thepen, T., Bihari, I.C., Knol, E.F., Van De Winkel, J.G., Bruijnzeel-Koomen, C.A. Br. J. Dermatol. (2000) [Pubmed]
  23. Aeroallergen patch testing for patients presenting to contact dermatitis clinics. Whitmore, S.E., Sherertz, E.F., Belsito, D.V., Maibach, H.I., Nethercott, J.R. J. Am. Acad. Dermatol. (1996) [Pubmed]
  24. Basophil histamine release and lymphocyte proliferation tests in latex contact urticaria. In vitro tests in latex contact urticaria. Turjanmaa, K., Räsänen, L., Lehto, M., Mäkinen-Kiljunen, S., Reunala, T. Allergy (1989) [Pubmed]
  25. Quinidine-induced thrombocytopenia with pulmonary hemorrhage. Alperin, J.B., deGroot, W.J., Cimo, P.L. Arch. Intern. Med. (1980) [Pubmed]
  26. Development of a screening system for cystic fibrosis. Coury, A.J., Fogt, E.J., Norenberg, M.S., Untereker, D.F. Clin. Chem. (1983) [Pubmed]
  27. Vaccines without thiomersal: why so necessary, why so long coming? van't Veen, A.J. Drugs (2001) [Pubmed]
  28. Constitutive endothelial and inducible nitric oxide synthase in inflammatory dermatoses. Rowe, A., Farrell, A.M., Bunker, C.B. Br. J. Dermatol. (1997) [Pubmed]
  29. Vascular endothelium express CS-1 fibronectin in allergic contact dermatitis. Martín, A.P., Ortiz, S., Cabalier, M.E., Frede, S., Burgos, E., Hliba, E., Serra, H. J. Cutan. Pathol. (2002) [Pubmed]
  30. Expression of adhesion molecules in early allergic patch test reactions. Brasch, J., Sterry, W. Dermatology (Basel) (1992) [Pubmed]
  31. Increased number of immunoreactive nerve fibers in atopic dermatitis. Tobin, D., Nabarro, G., Baart de la Faille, H., van Vloten, W.A., van der Putte, S.C., Schuurman, H.J. J. Allergy Clin. Immunol. (1992) [Pubmed]
  32. Increases in human epidermal DR+CD1+, DR+CD1-CD36+, and DR-CD3+ cells in allergic versus irritant patch test responses. Gerberick, G.F., Rheins, L.A., Ryan, C.A., Ridder, G.M., Haren, M., Miller, C., Oelrich, D.M., von Bargen, E. J. Invest. Dermatol. (1994) [Pubmed]
  33. Diagnosing nonimmediate reactions to penicillins by in vivo tests. Romano, A., Viola, M., Mondino, C., Pettinato, R., Di Fonso, M., Papa, G., Venuti, A., Montuschi, P. Int. Arch. Allergy Immunol. (2002) [Pubmed]
  34. Adhesion molecules in atopic dermatitis: upregulation of alpha6 integrin expression in spontaneous lesional skin as well as in atopen, antigen and irritative induced patch test reactions. Jung, K., Imhof, B.A., Linse, R., Wollina, U., Neumann, C. Int. Arch. Allergy Immunol. (1997) [Pubmed]
  35. Evaluating the relevance of aeroallergen sensitization in atopic eczema with the atopy patch test: a randomized, double-blind multicenter study. Atopy Patch Test Study Group. Darsow, U., Vieluf, D., Ring, J. J. Am. Acad. Dermatol. (1999) [Pubmed]
WikiGenes - Universities