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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Virulence of rimantadine-resistant human influenza A (H3N2) viruses in ferrets.

The influence of rimantadine-resistance mutations on the virulence of human H3N2 viruses in ferrets was examined. The similarities in virulence of the drug-resistant mutants with single amino acid substitutions at three different locations, 27, 30, and 31, within the M2 sequence and their corresponding sensitive wild-type isolates contrasted with differences in virulence between the three pairs of viruses. These data provide further evidence that rimantadine-resistant viruses that emerge during treatment of patients with the drug are unaltered both in their growth characteristics and virulence.[1]


  1. Virulence of rimantadine-resistant human influenza A (H3N2) viruses in ferrets. Sweet, C., Hayden, F.G., Jakeman, K.J., Grambas, S., Hay, A.J. J. Infect. Dis. (1991) [Pubmed]
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