Disease relevance of Ferrets

• Hyperammonemia and coma were produced in young male ferrets by a brief feeding of an arginine-deficient diet [1].
• Liver levels of lipids, proteins, and several urea-cycle enzymes were also determined in the comatose ferrets and compared with those of untreated controls and of controls treated with influenza or aspirin, or both [1].
• In vivo MRI visualization of acute myocardial ischemia and reperfusion in ferrets by the persistent action of the contrast agent Gd (BME-DTTA) [2].
• No squamous metaplasia or PCNA overexpression were found in the lungs of control ferrets or those supplemented with lycopene alone [3].
• Juvenile ferrets were vaccinated twice with these constructs, or with an attenuated live-virus vaccine, while controls received saline or the NYVAC and ALVAC vectors expressing rabies virus glycoprotein [4].

Psychiatry related information on Ferrets

• Cortical binocularity is abolished by monocular deprivation (MD) during a critical period of development lasting from approximately postnatal day (P) 35 to P70 in ferrets [5].
• Thus, fluctuations of estradiol levels are a factor which may affect fluctuations of predatory behavior in female ferrets [6].

High impact information on Ferrets

• BACKGROUND: The localization of substance P in brain-stem regions associated with vomiting, and the results of studies in ferrets, led us to postulate that a neurokinin-1-receptor antagonist would be an antiemetic in patients receiving anticancer chemotherapy [7].
• Cells from the cerebral proliferative zones of newborn ferrets were labeled with tritiated thymidine and a fluorescent dye and were transplanted as a single-cell suspension into the occipital region of newborn ferrets [8].
• CH58's NS gene partially attenuated VN1203 in ferrets but not in mice [9].
• Retinoid signaling and activator protein-1 expression in ferrets given beta-carotene supplements and exposed to tobacco smoke [10].
• The dose-response relationships of norepinephrine and sympathetic nerve stimulation were enhanced by 10(-6) M cocaine in control muscles; this did not occur in muscles from reserpine pretreated ferrets [11].

Chemical compound and disease context of Ferrets

• Compounds 44a and 64 were orally active in the protection against cisplatin-induced emesis in dogs or ferrets [12].
• GG167 (4-guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid) is a novel viral neuraminidase (sialidase) inhibitor which, following intranasal administration in ferrets, is at least 100 to 1,000 times more effective than ribavirin and amantadine against influenza A and B viruses [13].
• MNNG-induced gastric carcinoma in ferrets infected with Helicobacter mustelae [14].
• Moreover, 11 (23%) of the 47 Stm-treated ferrets inoculated with 86-24 Stm(r) or B2F1 Stm(r) developed hematuria and/or histological damage to glomeruli or thrombocytopenia, compared with 0 of 14 uninfected control animals receiving Stm in water [15].
• Influenza viruses resistant to the antiviral drug oseltamivir: transmission studies in ferrets [16].

Biological context of Ferrets

• Sera from ferrets vaccinated with these inactivated preparations had high virus neutralization titers, but their hemagglutination inhibition (HI) titers were usually low [17].
• Lycopene supplementation inhibits lung squamous metaplasia and induces apoptosis via up-regulating insulin-like growth factor-binding protein 3 in cigarette smoke-exposed ferrets [3].
• Ocular dominance columns form in ferrets between postnatal day 35 (P35) and P60 [18].
• Effects of testosterone, dihydrotestosterone, or estradiol administered neonatally on sexual behavior of female ferrets [19].
• Relatively high levels of testosterone 5 alpha-reductase activity were found in all brain regions across all perinatal ages, as well as in gonadectomized adult ferrets; there was no sex differences at any postnatal age studied [20].

Anatomical context of Ferrets

• METHODS: A high concentration of beta-carotene was perfused through the upper portion of the small intestine of ferrets in vivo with varying levels of alpha-tocopherol [21].
• Feces of ferrets were cultured for H. mustelae before, during, and after omeprazole therapy [22].
• We examined the distribution of immunocytochemically detectable NMDAR1 in visual cortex of cats and ferrets from late embryonic ages to adulthood [23].
• Injections of an antimitotic (methylazoxy methanol - MAM) into pregnant ferrets result in a constellation of effects, which include disruption of radial glia, with early differentiation in astrocytes, and impaired migration of neurons into the cortical plate [24].
• Sexually dimorphic processing of somatosensory and chemosensory inputs to forebrain luteinizing hormone-releasing hormone neurons in mated ferrets [25].

Associations of Ferrets with chemical compounds

• METHODS: Ferrets were given a beta-carotene supplement, exposed to cigarette smoke, or both for 6 months [10].
• Functional studies involved microinjection of L-glutamate into the caudal dorsal motor nucleus of the vagus to evoke an LES relaxation in decerebrate unanesthetized ferrets [26].
• To examine the time course of spine formation, crystals of 1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate were placed in the LGN in brain slices from 14- to 18-day-old ferrets [27].
• When tested in a T-maze after gonadectomy and treatment with estradiol benzoate (EB), female ferrets prefer to approach and receive neck grips from a stimulus male whereas males prefer to approach and neck grip an estrous female [28].
• Ovariectomized, EB-treated female ferrets with bilateral mPOA/AH lesions, like control females, preferred to approach and receive neck grips from a stimulus male [28].

Gene context of Ferrets

• Animals treated with rTPA and alpha 2AP inhibitor (56.2 +/- 4.7% lysis) showed significantly greater lysis than all other treatment groups, including ferrets treated with the same dose of rTPA alone (38.5 +/- 6.3%, P < .01), with twice the rTPA dose alone (45.0 +/- 6.5%, P < .05), or with a control MAb (35.2 +/- 4.6%, P < .01) [29].
• Coronal sections of the cerebral wall from developing ferrets (newborn to adult) were double-stained with antibodies to vimentin and glial fibrillary acidic protein (GFAP) [30].
• The newly determined fPrnp sequence is similar to dog (Canis familiaris) and mink (Mustela putorius) Prnp, but differs significantly from both fPrnp sequences that were previously deposited in the GenBank [31].
• The levels of IL-1 and IL-6 detected in the plasma of infected ferrets were low and did not correlate with the onset, duration or magnitude of the fevers produced by clone 7a and A/Fiji [32].
• We used immunohistochemistry to examine the expression of the Fas ligand in the enteric nervous system of rats, mice, guinea-pigs, ferrets and humans [33].

Analytical, diagnostic and therapeutic context of Ferrets

• Passive immunization against GPI reduced the number of implantation sites in pregnant ferrets in a dose-dependent manner [34].
• We performed in vivo cerebral angiography and postmortem neurovascular dissection of latex-injected specimens of adult ferrets [35].
• Thirty-six male ferrets were treated in six groups-control, smoke-exposed (SM), low-dose beta-carotene (LBC), high-dose beta-carotene (HBC), low-dose beta-carotene plus smoke exposure (LBC+SM) or high-dose beta-carotene plus smoke exposure (HBC+SM)-for 6 months [36].
• Oral administration of cyclopentane neuraminidase inhibitors protects ferrets against influenza virus infection [37].
• Intraperitoneal injection of sodium benzoate to young ferrets fed arginine-free diet failed to decrease serum ammonia levels [38].

References