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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Ferrets


Psychiatry related information on Ferrets


High impact information on Ferrets

  • BACKGROUND: The localization of substance P in brain-stem regions associated with vomiting, and the results of studies in ferrets, led us to postulate that a neurokinin-1-receptor antagonist would be an antiemetic in patients receiving anticancer chemotherapy [7].
  • Cells from the cerebral proliferative zones of newborn ferrets were labeled with tritiated thymidine and a fluorescent dye and were transplanted as a single-cell suspension into the occipital region of newborn ferrets [8].
  • CH58's NS gene partially attenuated VN1203 in ferrets but not in mice [9].
  • Retinoid signaling and activator protein-1 expression in ferrets given beta-carotene supplements and exposed to tobacco smoke [10].
  • The dose-response relationships of norepinephrine and sympathetic nerve stimulation were enhanced by 10(-6) M cocaine in control muscles; this did not occur in muscles from reserpine pretreated ferrets [11].

Chemical compound and disease context of Ferrets


Biological context of Ferrets


Anatomical context of Ferrets


Associations of Ferrets with chemical compounds

  • METHODS: Ferrets were given a beta-carotene supplement, exposed to cigarette smoke, or both for 6 months [10].
  • Functional studies involved microinjection of L-glutamate into the caudal dorsal motor nucleus of the vagus to evoke an LES relaxation in decerebrate unanesthetized ferrets [26].
  • To examine the time course of spine formation, crystals of 1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate were placed in the LGN in brain slices from 14- to 18-day-old ferrets [27].
  • When tested in a T-maze after gonadectomy and treatment with estradiol benzoate (EB), female ferrets prefer to approach and receive neck grips from a stimulus male whereas males prefer to approach and neck grip an estrous female [28].
  • Ovariectomized, EB-treated female ferrets with bilateral mPOA/AH lesions, like control females, preferred to approach and receive neck grips from a stimulus male [28].

Gene context of Ferrets

  • Animals treated with rTPA and alpha 2AP inhibitor (56.2 +/- 4.7% lysis) showed significantly greater lysis than all other treatment groups, including ferrets treated with the same dose of rTPA alone (38.5 +/- 6.3%, P < .01), with twice the rTPA dose alone (45.0 +/- 6.5%, P < .05), or with a control MAb (35.2 +/- 4.6%, P < .01) [29].
  • Coronal sections of the cerebral wall from developing ferrets (newborn to adult) were double-stained with antibodies to vimentin and glial fibrillary acidic protein (GFAP) [30].
  • The newly determined fPrnp sequence is similar to dog (Canis familiaris) and mink (Mustela putorius) Prnp, but differs significantly from both fPrnp sequences that were previously deposited in the GenBank [31].
  • The levels of IL-1 and IL-6 detected in the plasma of infected ferrets were low and did not correlate with the onset, duration or magnitude of the fevers produced by clone 7a and A/Fiji [32].
  • We used immunohistochemistry to examine the expression of the Fas ligand in the enteric nervous system of rats, mice, guinea-pigs, ferrets and humans [33].

Analytical, diagnostic and therapeutic context of Ferrets


  1. Interactions of aspirin and other potential etiologic factors in an animal model of Reye syndrome. Deshmukh, D.R., Maassab, H.F., Mason, M. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  2. In vivo MRI visualization of acute myocardial ischemia and reperfusion in ferrets by the persistent action of the contrast agent Gd (BME-DTTA). Simor, T., Chu, W.J., Johnson, L., Safranko, A., Doyle, M., Pohost, G.M., Elgavish, G.A. Circulation (1995) [Pubmed]
  3. Lycopene supplementation inhibits lung squamous metaplasia and induces apoptosis via up-regulating insulin-like growth factor-binding protein 3 in cigarette smoke-exposed ferrets. Liu, C., Lian, F., Smith, D.E., Russell, R.M., Wang, X.D. Cancer Res. (2003) [Pubmed]
  4. Canine distemper virus (CDV) infection of ferrets as a model for testing Morbillivirus vaccine strategies: NYVAC- and ALVAC-based CDV recombinants protect against symptomatic infection. Stephensen, C.B., Welter, J., Thaker, S.R., Taylor, J., Tartaglia, J., Paoletti, E. J. Virol. (1997) [Pubmed]
  5. Recovery of cortical binocularity and orientation selectivity after the critical period for ocular dominance plasticity. Liao, D.S., Krahe, T.E., Prusky, G.T., Medina, A.E., Ramoa, A.S. J. Neurophysiol. (2004) [Pubmed]
  6. Annual rhythm and hormonal control of predatory behavior in female ferrets. Harrer, S., Schmidt, W.J. Physiol. Behav. (1986) [Pubmed]
  7. Reduction of cisplatin-induced emesis by a selective neurokinin-1-receptor antagonist. L-754,030 Antiemetic Trials Group. Navari, R.M., Reinhardt, R.R., Gralla, R.J., Kris, M.G., Hesketh, P.J., Khojasteh, A., Kindler, H., Grote, T.H., Pendergrass, K., Grunberg, S.M., Carides, A.D., Gertz, B.J. N. Engl. J. Med. (1999) [Pubmed]
  8. Migration and differentiation of cerebral cortical neurons after transplantation into the brains of ferrets. McConnell, S.K. Science (1985) [Pubmed]
  9. The polymerase complex genes contribute to the high virulence of the human H5N1 influenza virus isolate A/Vietnam/1203/04. Salomon, R., Franks, J., Govorkova, E.A., Ilyushina, N.A., Yen, H.L., Hulse-Post, D.J., Humberd, J., Trichet, M., Rehg, J.E., Webby, R.J., Webster, R.G., Hoffmann, E. J. Exp. Med. (2006) [Pubmed]
  10. Retinoid signaling and activator protein-1 expression in ferrets given beta-carotene supplements and exposed to tobacco smoke. Wang, X.D., Liu, C., Bronson, R.T., Smith, D.E., Krinsky, N.I., Russell, M. J. Natl. Cancer Inst. (1999) [Pubmed]
  11. Effects of cocaine on excitation-contraction coupling of aortic smooth muscle from the ferret. Egashira, K., Morgan, K.G., Morgan, J.P. J. Clin. Invest. (1991) [Pubmed]
  12. Novel 5-HT3 antagonists. Isoquinolinones and 3-aryl-2-pyridones. Matsui, T., Sugiura, T., Nakai, H., Iguchi, S., Shigeoka, S., Takada, H., Odagaki, Y., Nagao, Y., Ushio, Y., Ohmoto, K. J. Med. Chem. (1992) [Pubmed]
  13. GG167 (4-guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid) is a potent inhibitor of influenza virus in ferrets. Ryan, D.M., Ticehurst, J., Dempsey, M.H. Antimicrob. Agents Chemother. (1995) [Pubmed]
  14. MNNG-induced gastric carcinoma in ferrets infected with Helicobacter mustelae. Fox, J.G., Wishnok, J.S., Murphy, J.C., Tannenbaum, S.R., Correa, P. Carcinogenesis (1993) [Pubmed]
  15. Ferrets as a model system for renal disease secondary to intestinal infection with Escherichia coli O157:H7 and other Shiga toxin-producing E. coli. Woods, J.B., Schmitt, C.K., Darnell, S.C., Meysick, K.C., O'Brien, A.D. J. Infect. Dis. (2002) [Pubmed]
  16. Influenza viruses resistant to the antiviral drug oseltamivir: transmission studies in ferrets. Herlocher, M.L., Truscon, R., Elias, S., Yen, H.L., Roberts, N.A., Ohmit, S.E., Monto, A.S. J. Infect. Dis. (2004) [Pubmed]
  17. Role of specific hemagglutinin amino acids in the immunogenicity and protection of H5N1 influenza virus vaccines. Hoffmann, E., Lipatov, A.S., Webby, R.J., Govorkova, E.A., Webster, R.G. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  18. Establishment of patterned thalamocortical connections does not require nitric oxide synthase. Finney, E.M., Shatz, C.J. J. Neurosci. (1998) [Pubmed]
  19. Effects of testosterone, dihydrotestosterone, or estradiol administered neonatally on sexual behavior of female ferrets. Baum, M.J., Gallagher, C.A., Martin, J.T., Damassa, D.A. Endocrinology (1982) [Pubmed]
  20. Androgen aromatization and 5 alpha-reduction in ferret brain during perinatal development: effects of sex and testosterone manipulation. Tobet, S.A., Shim, J.H., Osiecki, S.T., Baum, M.J., Canick, J.A. Endocrinology (1985) [Pubmed]
  21. Vitamin E enhances the lymphatic transport of beta-carotene and its conversion to vitamin A in the ferret. Wang, X.D., Marini, R.P., Hebuterne, X., Fox, J.G., Krinsky, N.I., Russell, R.M. Gastroenterology (1995) [Pubmed]
  22. Role of gastric pH in isolation of Helicobacter mustelae from the feces of ferrets. Fox, J.G., Blanco, M.C., Yan, L., Shames, B., Polidoro, D., Dewhirst, F.E., Paster, B.J. Gastroenterology (1993) [Pubmed]
  23. Activity-dependent regulation of NMDAR1 immunoreactivity in the developing visual cortex. Catalano, S.M., Chang, C.K., Shatz, C.J. J. Neurosci. (1997) [Pubmed]
  24. Factors affecting the morphology of radial glia. Gierdalski, M., Juliano, S.L. Cereb. Cortex (2003) [Pubmed]
  25. Sexually dimorphic processing of somatosensory and chemosensory inputs to forebrain luteinizing hormone-releasing hormone neurons in mated ferrets. Wersinger, S.R., Baum, M.J. Endocrinology (1997) [Pubmed]
  26. Site of action of GABA(B) receptor for vagal motor control of the lower esophageal sphincter in ferrets and rats. McDermott, C.M., Abrahams, T.P., Partosoedarso, E., Hyland, N., Ekstrand, J., Monroe, M., Hornby, P.J. Gastroenterology (2001) [Pubmed]
  27. Rapid acquisition of dendritic spines by visual thalamic neurons after blockade of N-methyl-D-aspartate receptors. Rocha, M., Sur, M. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  28. Altered sexual partner preference in male ferrets given excitotoxic lesions of the preoptic area/anterior hypothalamus. Paredes, R.G., Baum, M.J. J. Neurosci. (1995) [Pubmed]
  29. Alpha 2-antiplasmin causes thrombi to resist fibrinolysis induced by tissue plasminogen activator in experimental pulmonary embolism. Butte, A.N., Houng, A.K., Jang, I.K., Reed, G.L. Circulation (1997) [Pubmed]
  30. Development of glial cells in the cerebral wall of ferrets: direct tracing of their transformation from radial glia into astrocytes. Voigt, T. J. Comp. Neurol. (1989) [Pubmed]
  31. Amino acid sequence of the Felis catus prion protein. Lysek, D.A., Nivon, L.G., Wüthrich, K. Gene (2004) [Pubmed]
  32. Are known pyrogenic cytokines responsible for fever in influenza? Price, G.E., Fenton, R.J., Smith, H., Sweet, C. J. Med. Virol. (1997) [Pubmed]
  33. Immunoreactivity for the Fas ligand in the mammalian enteric nervous system. Parr, E.J., Myles, E.B., Hanani, M., Seror, D., Riabowol, K.T., Sharkey, K.A. Cell Tissue Res. (1997) [Pubmed]
  34. Glucose-6-phosphate isomerase is necessary for embryo implantation in the domestic ferret. Schulz, L.C., Bahr, J.M. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  35. The ferret as an animal model in cerebrovascular research. Atkinson, C.S., Press, G.A., Lyden, P., Katz, B. Stroke (1989) [Pubmed]
  36. Effects of physiological versus pharmacological beta-carotene supplementation on cell proliferation and histopathological changes in the lungs of cigarette smoke-exposed ferrets. Liu, C., Wang, X.D., Bronson, R.T., Smith, D.E., Krinsky, N.I., Russell, R.M. Carcinogenesis (2000) [Pubmed]
  37. Oral administration of cyclopentane neuraminidase inhibitors protects ferrets against influenza virus infection. Sweet, C., Jakeman, K.J., Bush, K., Wagaman, P.C., McKown, L.A., Streeter, A.J., Desai-Krieger, D., Chand, P., Babu, Y.S. Antimicrob. Agents Chemother. (2002) [Pubmed]
  38. Effect of arginine-free diet on ammonia metabolism in young and adult ferrets. Thomas, P.E., Deshmukh, D.R. J. Nutr. (1986) [Pubmed]
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