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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Influenza, Human

 
 
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Disease relevance of Influenza, Human

 

High impact information on Influenza, Human

 

Chemical compound and disease context of Influenza, Human

  • CONCLUSIONS: In these trials, prophylaxis and early treatment with oral oseltamivir were both associated with significant antiviral and clinical effects in experimental human influenza [9].
  • Safety and efficacy of once daily intranasal zanamivir in preventing experimental human influenza A infection [2].
  • CONCLUSION: Early treatment with peramivir was associated with significant antiviral effects in experimentally induced influenza in humans [11].
  • Human influenza A virus hemagglutinin distinguishes sialyloligosaccharides in membrane-associated gangliosides as its receptor which mediates the adsorption and fusion processes of virus infection. Specificity for oligosaccharides and sialic acids and the sequence to which sialic acid is attached [12].
  • This provided evidence that rgPIV3 utilizes alpha2-6-linked sialic acid residues for initiating infection, a specificity also described for human influenza viruses [13].
 

Biological context of Influenza, Human

  • Only H1, H2, and H3 and N1 and N2 antigens have been found in human influenza viruses, but virologic history is too brief to preclude the contribution of other antigens to future pandemics [14].
  • Propagation of human influenza viruses in embryonated chicken eggs (CE) results in the selection of variants with amino acid substitutions near the receptor-binding site of the hemagglutinin (HA) molecule [15].
  • Evolution of the HA1 domain of human influenza A (H1N1) virus: loss of glycosylation sites and occurrence of herald and conserved strains [16].
  • Plasmids have been constructed in which promoters of 70-kDa heat-shock protein genes (hsp70) of human and Drosophila origin were linked to three different eukaryotic genes encoding human growth hormone (hGH), chicken lysozyme (cL) and a human influenza haemagglutinin (HA) [17].
  • There are currently three major human influenza viruses in global circulation, H1N1, H3N2 and B. OBJECTIVES: A one-step multiplex reverse transcription (RT)-polymerase chain reaction (PCR) assay targeting the HA1 segment of the human hemagglutinin gene was developed as a rapid surveillance method [18].
 

Anatomical context of Influenza, Human

 

Gene context of Influenza, Human

  • To study whether individual HLA class I alleles are used preferentially or equally in human virus-specific CTL responses, the contribution of individual HLA-A and -B alleles to the human influenza virus-specific CTL response was investigated [24].
  • Variation in the ability of human influenza A viruses to induce and inhibit the IFN-beta pathway [21].
  • Human influenza viral infection in utero alters glial fibrillary acidic protein immunoreactivity in the developing brains of neonatal mice [3].
  • We hypothesized that human influenza infection in day 9 pregnant mice would alter the expression of reelin in day 0 neonatal brains [25].
  • PB2s of human influenza A viruses share a common ancestor with classic swine virus PB2s, and the pattern of evolution suggests that the ancestor was an avian virus PB2 [26].
 

Analytical, diagnostic and therapeutic context of Influenza, Human

References

  1. Active influenza virus neuraminidase is expressed in monkey cells from cDNA cloned in simian virus 40 vectors. Davis, A.R., Bos, T.J., Nayak, D.P. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  2. Safety and efficacy of once daily intranasal zanamivir in preventing experimental human influenza A infection. Calfee, D.P., Peng, A.W., Hussey, E.K., Lobo, M., Hayden, F.G. Antivir. Ther. (Lond.) (1999) [Pubmed]
  3. Human influenza viral infection in utero alters glial fibrillary acidic protein immunoreactivity in the developing brains of neonatal mice. Fatemi, S.H., Emamian, E.S., Sidwell, R.W., Kist, D.A., Stary, J.M., Earle, J.A., Thuras, P. Mol. Psychiatry (2002) [Pubmed]
  4. The avian influenza virus nucleoprotein gene and a specific constellation of avian and human virus polymerase genes each specify attenuation of avian-human influenza A/Pintail/79 reassortant viruses for monkeys. Snyder, M.H., Buckler-White, A.J., London, W.T., Tierney, E.L., Murphy, B.R. J. Virol. (1987) [Pubmed]
  5. Pathogenicity of influenza viruses with genes from the 1918 pandemic virus: functional roles of alveolar macrophages and neutrophils in limiting virus replication and mortality in mice. Tumpey, T.M., García-Sastre, A., Taubenberger, J.K., Palese, P., Swayne, D.E., Pantin-Jackwood, M.J., Schultz-Cherry, S., Solórzano, A., Van Rooijen, N., Katz, J.M., Basler, C.F. J. Virol. (2005) [Pubmed]
  6. Structure of the neuraminidase gene in human influenza virus A/PR/8/34. Fields, S., Winter, G., Brownlee, G.G. Nature (1981) [Pubmed]
  7. Nucleotide sequence of the haemagglutinin gene of a human influenza virus H1 subtype. Winter, G., Fields, S., Brownlee, G.G. Nature (1981) [Pubmed]
  8. Evolution of human influenza A viruses over 50 years: rapid, uniform rate of change in NS gene. Buonagurio, D.A., Nakada, S., Parvin, J.D., Krystal, M., Palese, P., Fitch, W.M. Science (1986) [Pubmed]
  9. Use of the oral neuraminidase inhibitor oseltamivir in experimental human influenza: randomized controlled trials for prevention and treatment. Hayden, F.G., Treanor, J.J., Fritz, R.S., Lobo, M., Betts, R.F., Miller, M., Kinnersley, N., Mills, R.G., Ward, P., Straus, S.E. JAMA (1999) [Pubmed]
  10. Relative sensitivity of fetal and newborn mice to induction of hapten-specific B cell tolerance. Pike, B.L., Kay, T.W., Nossal, G.J. J. Exp. Med. (1980) [Pubmed]
  11. Efficacy and tolerability of the oral neuraminidase inhibitor peramivir in experimental human influenza: randomized, controlled trials for prophylaxis and treatment. Barroso, L., Treanor, J., Gubareva, L., Hayden, F.G. Antivir. Ther. (Lond.) (2005) [Pubmed]
  12. Human influenza A virus hemagglutinin distinguishes sialyloligosaccharides in membrane-associated gangliosides as its receptor which mediates the adsorption and fusion processes of virus infection. Specificity for oligosaccharides and sialic acids and the sequence to which sialic acid is attached. Suzuki, Y., Nagao, Y., Kato, H., Matsumoto, M., Nerome, K., Nakajima, K., Nobusawa, E. J. Biol. Chem. (1986) [Pubmed]
  13. Infection of ciliated cells by human parainfluenza virus type 3 in an in vitro model of human airway epithelium. Zhang, L., Bukreyev, A., Thompson, C.I., Watson, B., Peeples, M.E., Collins, P.L., Pickles, R.J. J. Virol. (2005) [Pubmed]
  14. Perspectives on pandemics: a research agenda. Kilbourne, E.D. J. Infect. Dis. (1997) [Pubmed]
  15. Effects of egg-adaptation on the receptor-binding properties of human influenza A and B viruses. Gambaryan, A.S., Robertson, J.S., Matrosovich, M.N. Virology (1999) [Pubmed]
  16. Evolution of the HA1 domain of human influenza A (H1N1) virus: loss of glycosylation sites and occurrence of herald and conserved strains. Pyhälä, R., Ikonen, N., Forsten, T., Alanko, S., Kinnunen, L. J. Gen. Virol. (1995) [Pubmed]
  17. High-level, heat-regulated synthesis of proteins in eukaryotic cells. Dreano, M., Brochot, J., Myers, A., Cheng-Meyer, C., Rungger, D., Voellmy, R., Bromley, P. Gene (1986) [Pubmed]
  18. A rapid, single-step multiplex reverse transcription-PCR assay for the detection of human H1N1, H3N2, and B influenza viruses. Daum, L.T., Canas, L.C., Schadler, C.A., Ujimori, V.A., Huff, W.B., Barnes, W.J., Lohman, K.L. J. Clin. Virol. (2002) [Pubmed]
  19. African green monkey kidney (Vero) cells provide an alternative host cell system for influenza A and B viruses. Govorkova, E.A., Murti, G., Meignier, B., de Taisne, C., Webster, R.G. J. Virol. (1996) [Pubmed]
  20. Safety and efficacy of intravenous zanamivir in preventing experimental human influenza A virus infection. Calfee, D.P., Peng, A.W., Cass, L.M., Lobo, M., Hayden, F.G. Antimicrob. Agents Chemother. (1999) [Pubmed]
  21. Variation in the ability of human influenza A viruses to induce and inhibit the IFN-beta pathway. Hayman, A., Comely, S., Lackenby, A., Murphy, S., McCauley, J., Goodbourn, S., Barclay, W. Virology (2006) [Pubmed]
  22. Influenza A mutant viruses with altered NS1 protein function provoke caspase-1 activation in primary human macrophages, resulting in fast apoptosis and release of high levels of interleukins 1beta and 18. Stasakova, J., Ferko, B., Kittel, C., Sereinig, S., Romanova, J., Katinger, H., Egorov, A. J. Gen. Virol. (2005) [Pubmed]
  23. Intracellular cleavage of human influenza a virus hemagglutinin and its inhibition. Zhirnov, O.P., Vorobjeva, I.V., Ovcharenko, A.V., Klenk, H.D. Biochemistry Mosc. (2003) [Pubmed]
  24. Preferential HLA usage in the influenza virus-specific CTL response. Boon, A.C., De Mutsert, G., Fouchier, R.A., Sintnicolaas, K., Osterhaus, A.D., Rimmelzwaan, G.F. J. Immunol. (2004) [Pubmed]
  25. Defective corticogenesis and reduction in Reelin immunoreactivity in cortex and hippocampus of prenatally infected neonatal mice. Fatemi, S.H., Emamian, E.S., Kist, D., Sidwell, R.W., Nakajima, K., Akhter, P., Shier, A., Sheikh, S., Bailey, K. Mol. Psychiatry (1999) [Pubmed]
  26. Evolution of influenza A virus PB2 genes: implications for evolution of the ribonucleoprotein complex and origin of human influenza A virus. Gorman, O.T., Donis, R.O., Kawaoka, Y., Webster, R.G. J. Virol. (1990) [Pubmed]
  27. Sequence analysis of the polymerase 1 gene and the secondary structure prediction of polymerase 1 protein of human influenza virus A/WSN/33. Sivasubramanian, N., Nayak, D.P. J. Virol. (1982) [Pubmed]
  28. Chitosan as a novel nasal delivery system for vaccines. Illum, L., Jabbal-Gill, I., Hinchcliffe, M., Fisher, A.N., Davis, S.S. Adv. Drug Deliv. Rev. (2001) [Pubmed]
  29. Inhibition of replication of avian influenza viruses by the neuraminidase inhibitor 4-guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid. Gubareva, L.V., Penn, C.R., Webster, R.G. Virology (1995) [Pubmed]
  30. Measurement of antibodies to avian influenza virus A(H7N7) in humans by hemagglutination inhibition test. Meijer, A., Bosman, A., van de Kamp, E.E., Wilbrink, B., van Beest Holle, M.d.u. .R., Koopmans, M. J. Virol. Methods (2006) [Pubmed]
 
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