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Abir, R. et al.

Ronit Abir, Asangla Ao, Xiao Yun Zhang, Roni Garor, Shmuel Nitke, Benjamin Fisch,

Vascular endothelial growth factor A and its two receptors in human preantral follicles from fetuses, girls, and women.

OBJECTIVE: To investigate the expression of vascular endothelial growth factor A (VEGF-A) and that its two receptors (VEGFR1, VEGFR2) in human preantral follicles. DESIGN: Immunohistochemical, in situ hybridization, and reverse transcriptase polymerase chain reaction (RT-PCR) study of the expression of the VEGF-A system in human ovaries. SETTING: Major tertiary-care academic center. PATIENT(S): Twenty-two patients who underwent pregnancy terminations at 21-35 gestational weeks and 29 girls/women aged 5-39 years who underwent ovarian laparoscopies. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Laboratory analysis of human ovarian specimens. RESULT(S): Immunhistochemistry and in situ hybridization revealed the expression of the proteins and mRNA transcripts for VEGFR1 and VEGFR2 in oocytes, granulosa cells, and stroma cells from fetuses and girls/women. The protein for VEGF-A was detected immunohistochemically in oocytes, granulosa cells, and stroma cells from fetuses and girls. VEGF-A and VEGFR1 proteins were expressed more strongly than VEGFR2. VEGF-A(121), VEGF-A(165), and VEGF-A(189) isoforms were identified by RT-PCR in the ovarian samples from fetuses and women. CONCLUSION(S): The presence of the VEGF-A receptors, particularly in the granulosa cells, suggests that VEGF-A might be involved in proliferation initiation of primordial follicles or play an as yet unknown role in human preantral follicles.[1]

References

Vascular endothelial growth factor A and its two receptors in human preantral follicles from fetuses, girls, and women. Abir, R., Ao, A., Zhang, X.Y., Garor, R., Nitke, S., Fisch, B. Fertil. Steril. (2010) [Pubmed]

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