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Mills, P.J. et al.

Paul J. Mills, Loki Natarajan, Roland von Känel, Sonia Ancoli-Israel, Joel E. Dimsdale,

Diurnal variability of C-reactive protein in obstructive sleep apnea.

OBJECTIVE: The objective of this study is to examine the diurnal variability of C-reactive protein (CRP) in obstructive sleep apnea (OSA). METHODS AND MEASUREMENTS: Participants included 44 women and men with untreated OSA (mean apnea/hypopnea index = 37.5, SD +/- 28) and 23 healthy adults with no OSA. Sleep was monitored with polysomnography in the University of California San Diego General Clinical Research Center. Over a 24-h period, blood was collected every 2 h, and CRP levels were determined. RESULTS: Adjusting for age, gender, and body mass index, a significant group by time interaction showed that patients with OSA had higher CRP levels during the daytime (8:00 a.m.-8:00 p.m.) versus the nighttime (10:00 p.m. until 6:00 p.m.; p < 0.001). Non-apneics showed no significant change in CRP levels during the 24 h. CONCLUSIONS: The findings indicate that sleep apnea patients have disproportionately elevated CRP levels in the day versus the nighttime, possibly as a result of carryover effects of nighttime arousal into the daytime.[1]

References

Diurnal variability of C-reactive protein in obstructive sleep apnea. Mills, P.J., Natarajan, L., von Känel, R., Ancoli-Israel, S., Dimsdale, J.E. Sleep. Breath (2009) [Pubmed]

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