Disease relevance of Sleep Apnea, Obstructive

• Nine adult patients with obstructive sleep apnea syndrome were administered medroxyprogesterone acetate, 60 to 120 mg/day, and the effect of medroxyprogesterone on clinical symptoms and obstructive apneas during sleep was assessed [1].
• We conclude that (1) the amount of inflammatory markers is linked to obesity rather than to sleep-related breathing disorders, and (2) obstructive sleep apnea is associated with a structural alteration of the extracellular matrix of upper airway tissue [2].
• We studied 50 consecutive patients to test the hypothesis that successful treatment of obstructive sleep apnea with nasal continuous positive airway pressure (nasal CPAP) will decrease automobile accidents in patients with sleep apnea [3].
• Allergic rhinitis (AR) is rarely found in isolation and needs to be considered in the context of systemic allergic disease associated with numerous comorbid disorders, including asthma, chronic middle ear effusions, sinusitis, lymphoid hypertrophy with obstructive sleep apnea, disordered sleep, and consequent behavioral and educational effects [4].
• Conclusions: In patients with nonischemic dilated cardiomyopathy, the presence of obstructive sleep apnea is associated with an increased prevalence of left ventricular hypertrophy [5].

Psychiatry related information on Sleep Apnea, Obstructive

• Although it is still unknown how much CPAP use is sufficient to prevent daytime hypersomnolence in obstructive sleep apnea syndrome, sleeping without CPAP for one night reversed the beneficial effects of 1 month of CPAP use [6].
• CONCLUSIONS: These results confirm previous shorter-term controlled trials, indicating modafinil is a useful adjunct therapy for improving wakefulness in patients with residual excessive sleepiness associated with obstructive sleep apnea/hypopnea syndrome who were treated with nCPAP [7].
• Two of 13 children with PLM > 5 per hour and no evidence of obstructive sleep apnea had attention-deficit/hyperactivity disorder [8].
• Adult onset enuresis accompanied by obstructive sleep apnea has been reported rarely [9].
• Erectile dysfunction in men with obstructive sleep apnea syndrome: a randomized study of the efficacy of sildenafil and continuous positive airway pressure [10].

High impact information on Sleep Apnea, Obstructive

• Obstructive sleep apnea syndrome induced by testosterone administration [11].
• Children and adolescents with obstructive sleep apnea reported a significantly lower health-related QOL total score (mean [SD], 53.8 [13.3]) than obese children and adolescents without obstructive sleep apnea (mean [SD], 67.9 [16.2]) [12].
• The cardiomyopathy of obstructive sleep apnea [13].
• OBJECTIVES: This study was designed to determine whether reductions in morning systolic blood pressure (BP) elicited by treatment of moderate to severe obstructive sleep apnea (OSA) in heart failure (HF) patients are associated with a reduction in sympathetic vasoconstrictor tone [14].
• A number of recent studies have described the presence of significant gastroesophageal reflux (GER) in patients with obstructive sleep apnea (OSA) [15].

Chemical compound and disease context of Sleep Apnea, Obstructive

• This result has implications for pharmacologic strategies aiming to increase GG activity by manipulating endogenous serotonin in patients with obstructive sleep apnea [16].
• Modafinil as adjunct therapy for daytime sleepiness in obstructive sleep apnea [17].
• Supplemental O2 is sometimes used to treat children with the obstructive sleep apnea syndrome (OSAS) [18].
• OBJECTIVE: The objective of this study was to determine relationships between risk and severity of obstructive sleep apnea (OSA) and glucose metabolism in PCOS [19].
• Androgen therapy may precipitate obstructive sleep apnea in men [20].

Biological context of Sleep Apnea, Obstructive

• OBJECTIVE: To investigate the effects of modafinil, a central nonamphetamine awakening substance, on blood pressure and heart rate in hypersomnolent patients with obstructive sleep apnea [21].
• Polycystic ovary syndrome is associated with obstructive sleep apnea and daytime sleepiness: role of insulin resistance [22].
• We therefore sought to determine if the haptoglobin phenotype was a determinant of cardiovascular disease in patients with obstructive sleep apnea syndrome [23].
• Effects of nasal continuous positive airway pressure and oxygen supplementation on norepinephrine kinetics and cardiovascular responses in obstructive sleep apnea [24].

Anatomical context of Sleep Apnea, Obstructive

• Surgical treatment of a patient with obstructive sleep apnea syndrome associated with temporomandibular joint destruction by rheumatoid arthritis [25].
• The mechanisms by which obesity and obstructive sleep apnea increase aldosterone levels and raise blood pressure are not understood, but sympathetic nervous system activation and production of nonclassical adrenal stimuli are two possibilities [26].
• As elevated CRP levels are considered markers of the acute phase response and characterize progression of vascular injury in coronary artery disease, it is likely that obstructive sleep apnea could lead to worsening of vasculopathy [27].
• The purpose of this study was to determine whether neutral endopeptidase (NEP; EC3.4.24.11) is decreased in the uvula epithelium of patients with obstructive sleep apnea (OSA) [28].

Gene context of Sleep Apnea, Obstructive

• Increased levels of circulating ICAM-1, VCAM-1, and L-selectin in obstructive sleep apnea syndrome [29].
• Effects of obstructive sleep apnea on circulating ICAM-1, IL-8, and MCP-1 [30].
• APOE epsilon4 is associated with obstructive sleep apnea/hypopnea: the Sleep Heart Health Study [31].
• We examined serum levels of MMP-9 and its inhibitor, tissue inhibitor of metalloproteinase-1 (TIMP-1), activity of MMP-9, and the effect of nasal continuous positive airway pressure (nCPAP) in patients with obstructive sleep apnea syndrome (OSAS) [32].
• Glucocorticoid receptor subunit expression in adenotonsillar tissue of children with obstructive sleep apnea [33].

Analytical, diagnostic and therapeutic context of Sleep Apnea, Obstructive

• Modafinil may be a useful adjunct treatment for the management of residual daytime sleepiness in patients with obstructive sleep apnea/hypopnea syndrome who are regular users of nasal continuous positive airway pressure therapy [17].
• We measured nocturnal plasma erythropoietin concentration (EPO) in eight subjects with obstructive sleep apnea syndrome (OSAS) and eight healthy overweight subjects while they were undergoing nocturnal polysomnography [34].
• Because successful medical treatment of obstructive sleep apnea/hypopnea syndrome (SAHS) depends on adequate CPAP treatment, we have analyzed in nine SAHS patients the behavior of respiratory and neurological parameters during a stepwise, polysomnography-controlled CPAP titration to achieve an optimal CPAP [35].
• Fifty-one middle-aged male patients with obstructive sleep apnea syndrome (OSAS) were evaluated using two-dimensional echocardiography, 24-h blood pressure measurements, polysomnography, and plasma norepinephrine (NE) measurements [36].
• RESULTS: Baseline erythropoietin levels before sleep were similar in the obstructive sleep apnea and control groups [37].

References