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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Severe cholestatic jaundice associated with piroxicam.

A 62-year-old man with rheumatoid arthritis developed jaundice while taking piroxicam. A full evaluation including ultrasound, computerized tomography, endoscopic cholangiography, and liver biopsy confirmed the diagnosis of intrahepatic cholestasis. The patient's jaundice and all other liver function abnormalities normalized 4 months after he discontinued taking piroxicam. This is the first case report in the United States of severe liver toxicity associated with piroxicam. The six cases in the English-language literature are reviewed, featuring the presentation, patterns of liver injury, and outcome in each. Piroxicam should be considered as a potential cause of cholestatic jaundice when other more common etiologies have been excluded.[1]


  1. Severe cholestatic jaundice associated with piroxicam. Hepps, K.S., Maliha, G.M., Estrada, R., Goodgame, R.W. Gastroenterology (1991) [Pubmed]
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