Disease relevance of Jaundice, Obstructive

• Albumin-bound bilirubin was an important fraction (8 to 90 per cent) of total bilirubin in patients with hepatocellular and cholestatic jaundice as well as in patients with the Dubin-Johnson syndrome [1].
• BACKGROUND & AIMS: Arginine deficiency may underlie the cellular immune depression after surgery in obstructive jaundice, which is associated with gut-derived endotoxemia [2].
• The serum RNase activities of four patients with resectable "curable") pancreatic carcinoma and two others with advanced pancreatic cancer without obstructive jaundice were normal [3].
• In patients with cirrhosis and in those with obstructive jaundice, the cysteinyl leukotrienes in urine were negatively correlated with creatinine clearance [4].
• The hamster model of DES-induced icterus showed many clinical dissimilarities when compared to the human estrogen-induced jaundice, simple cholestatic jaundice [5].

Psychiatry related information on Jaundice, Obstructive

• We conducted a study to examine the role of cholecystokinin in feeding behavior and weight change in rats with obstructive jaundice [6].

High impact information on Jaundice, Obstructive

• Patients with obstructive jaundice and elevated CEA levels do not necessarily have cancer [7].
• Intraductal mucin was confirmed intraoperatively and pathologically as the cause of the obstructive jaundice [8].
• Changes in pro-oxidant and antioxidant balance in the serum and liver were studied in an experimental model of obstructive jaundice in the rat [9].
• Severe cholestatic jaundice associated with piroxicam [10].
• Endogenous pancreatic prostaglandin production in control and obstructive jaundice was investigated using isolated and perfused dog pancreas [11].

Chemical compound and disease context of Jaundice, Obstructive

• Cephalosporin-induced cholestatic jaundice [12].
• Obstructive jaundice, pancytophenia and hydralazine [13].
• Captopril-associated cholestatic jaundice [14].
• Cholestatic jaundice associated with flurazepam hydrochloride [15].
• Cholestatic jaundice and aminoglutethimide [16].

Biological context of Jaundice, Obstructive

• AIM: The aim of this study in rats was to investigate the incidence of bacterial translocation in portal hypertension and obstructive jaundice, and to evaluate the effects of allopurinol and glutamine [17].
• METHODS: Liver concentrations of total glutathione, protein sulfhydryls and malondialdehyde (end-product of lipid peroxidation) were measured in hepatic specimens of 12 patients with obstructive jaundice before and after the application of an external biliary drainage and in six control subjects [18].
• Upregulation of MRP2 in the kidneys and MRP3 in the liver may be a compensatory mechanism to improve bilirubin clearance during obstructive jaundice [19].
• We tested the effect of molsidomine on survival and hepatocyte apoptosis in a model of obstructive jaundice and endotoxemia [20].
• Abnormal pancreatic beta-cell function is detectable in patients with pancreatic carcinoma before any change in glucose homeostasis, particularly in patients with obstructive jaundice [21].

Anatomical context of Jaundice, Obstructive

• Renal endothelin system in obstructive jaundice: its role in impaired renal function of bile-duct ligated rats [22].
• Analysis of hepatic transport of cefpiramide in rats with obstructive jaundice by using isolated hepatocytes [23].
• CONCLUSIONS: Experimental obstructive jaundice induces regional loss of occludin expression in the intestinal epithelium, which may be a key factor contributing to the disruption of the mucosal barrier [24].
• This is the first case of obstructive jaundice due to histologically confirmed amyloid-like deposits in the biliary system [25].
• Our results suggest that severe disturbances of body-fluid compartments may be the basic mechanism underlying kidney dysfunction in obstructive jaundice and that further water depletion induced by mannitol may indeed prove detrimental [26].

Gene context of Jaundice, Obstructive

• Obstructive jaundice causes alterations in circulating endotoxin binding proteins and IL-8 [27].
• The plasma levels of plasminogen activator inhibitor (PAI) in 29 patients with obstructive jaundice were found significantly increased as compared to 20 nonjaundiced patients [28].
• Lp-X isolated from sera of patients with obstructive jaundice had a high content of unesterified cholesterol and phosphatidylcholine and contained apolipoprotein E, apoCs, and albumin [29].
• This study was undertaken to evaluate the production of two important immunoregulatory molecules, interleukin-1 (IL-1) and interleukin-2 (IL-2), by peripheral blood mononuclear cells in cancer patients with obstructive jaundice before and after percutaneous transhepatic biliary drainage (PTBD) [30].
• Soluble isoforms of CEACAM1 containing the A2 domain: increased serum levels in patients with obstructive jaundice and differences in 3-fucosyl-N-acetyl-lactosamine moiety [31].

Analytical, diagnostic and therapeutic context of Jaundice, Obstructive

• The LTB4 level increased during obstructive jaundice and after hepatectomy [32].
• Thin needle cholangiography (TNC) was performed in 50 patients with obstructive jaundice or jaundice of obscure origin [33].
• The development of the enzyme immunoassay using glass beads shortens analysis time; furthermore, the method makes it possible to detect obstructive jaundice in rabbits before the serum bilirubin level is elevated [34].
• After hepatic reperfusion, the disappearance rate of serum hyaluronic acid in obstructive jaundice was lower, and serum alanine aminotransferase levels were higher than those in the Sham group [35].
• They also showed by Western blot analysis that TGF-alpha protein was present in hepatic bile samples obtained from patients with obstructive jaundice [36].

References