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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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5 alpha-reductase activity in polycystic ovary syndrome.

11 patients with polycystic ovary syndrome (hirsutism and oligomenorrhoea), but with no deficiency of 21-hydroxylase or 3 beta-hydroxysteroid dehydrogenase, had abnormal cortisol metabolism. The high ratio of 5 alpha to 5 beta cortisol metabolites in the urine is consistent with enhanced activity of 5 alpha-reductase. Urinary total cortisol metabolites were higher in patients than controls. Increased 5 alpha-reductase activity in liver and skin enhances hepatic cortisol metabolism at the expense of androgen excess and may be the underlying abnormality in polycystic ovary syndrome.[1]

References

  1. 5 alpha-reductase activity in polycystic ovary syndrome. Stewart, P.M., Shackleton, C.H., Beastall, G.H., Edwards, C.R. Lancet (1990) [Pubmed]
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