Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Westra, J. et al.

Johanna Westra, Elisabeth Brouwer, Erwin Bouwman, Berber Doornbos-van der Meer, Marcel D. Posthumus, Miek A. van Leeuwen, Pieter C. Limburg, Yutaka Ueda, Cees G. M. Kallenberg,

Role for CaMKII inhibition in rheumatoid arthritis: effects on HIF-1-induced VEGF production by rheumatoid synovial fibroblasts.

BACKGROUND AND AIMS: The present study was designed to investigate the effects of a novel CaMKII inhibitor SMP-114, which was effective in a collagen-induced arthritis model in rats, on rheumatoid synovial fibroblasts. METHODS: Rheumatoid synovial fibroblasts (RSF) were cultured under pro-inflammatory (IL-1beta stimulation) and hypoxic conditions. Protein and mRNA expression of HIF-1alpha and the effects of inhibitors of the CaMKII-, PI3K-, and ERK pathway on VEGF and IL-6 production were analyzed. RESULTS: Stimulation under hypoxic conditions induced higher expression of HIF-1alpha and VEGF mRNA than treatment with either IL-1beta or hypoxia alone. However, incubation with a specific CaMKII inhibitor did not result in reduced VEGF production in RSF. CONCLUSIONS: CaMKII activation has been reported to be involved in HIF-1alpha stabilization, but incubation with SMP-114, a specific CaMKII inhibitor, had no effect on HIF-1-induced VEGF production by rheumatoid synovial fibroblasts.[1]

References

Role for CaMKII inhibition in rheumatoid arthritis: effects on HIF-1-induced VEGF production by rheumatoid synovial fibroblasts. Westra, J., Brouwer, E., Bouwman, E., Doornbos-van der Meer, B., Posthumus, M.D., van Leeuwen, M.A., Limburg, P.C., Ueda, Y., Kallenberg, C.G. Ann. N. Y. Acad. Sci. (2009) [Pubmed]

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