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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Somatostatin secretion and action in the regulation of growth hormone secretion.

The inhibition of growth hormone (GH) secretion by the hypothalamic peptide, somatostatin, is mediated by two critical factors: the concentration of the peptide in hypothalamic portal plasma and the number of somatostatin ( SRIF) receptors on the somatotroph. The secretory patterns of SRIF and GH- releasing hormone (GRH) in portal blood of unanesthetized sheep is pulsatile and a close relationship of GRH pulses to those of GH secretion was documented, while those of SRIF appear to have more of a modulatory role on the responses to GRH. Peripheral infusion of SRIF at a rate to provide concentrations comparable to those in the portal system leads to a desensitization of SRIF effects on the somatotroph, likely mediated by down-regulation of SRIF receptors. These effects are believed to modulate the GH responses to GRH secretion in the generation of pulsatile GH secretion.[1]

References

  1. Somatostatin secretion and action in the regulation of growth hormone secretion. Frohman, L.A., Downs, T.R., Kelijman, M., Clarke, I.J., Thomas, G. Metab. Clin. Exp. (1990) [Pubmed]
 
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