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Gene Review

LOC443338  -  secretory protein

Ovis aries

Synonyms: A4, PLP2
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Disease relevance of LOC443338


High impact information on LOC443338


Chemical compound and disease context of LOC443338


Biological context of LOC443338

  • An antiserum against total ovine conceptus secretory proteins, from which IFN-tau and proteins common to maternal uterine tract secretions had first been removed, was used to immunoscreen cDNA libraries created from mRNA of days 13 and 15 ovine conceptuses [15].
  • Selective cloning of cDNA for secretory proteins of early embryos. Identification of a transiently expressed kunitz domain protein from preimplantation sheep trophoblast [15].
  • The changes in the secretory IgA system which occur locally during lactation are thought to be hormone-dependent [16].
  • Immunoregulation of localized and disseminated murine myeloma: antigen-specific regulation of MOPC-315 stem cell proliferation and secretory cell differentiation [17].
  • More powerful isolation procedures are needed, however, for more exacting analysis of LC functions, such as their role in immune induction, their secretory capacities including production of EC-derived thymocyte-activating factor (7, 8) and prostaglandins, immune endocytosis, the role of LC granules, etc [18].

Anatomical context of LOC443338


Associations of LOC443338 with chemical compounds

  • Thyrotropin induces the acidification of the secretory granules of parafollicular cells by increasing the chloride conductance of the granular membrane [21].
  • Finally, an oligoclonal family of Sec clones revealed a striking trend toward acquisition of glutamic/aspartic acid, suggesting some degree of selection [23].
  • Propionate (0.5 mmole per kilogram) and arginine (10 gm.) induced a rise in plasma insulin and GH, and glucagon was effectively blocked by cyclic somatostatin (0.5 mg.). Similarly, somatostatin inhibited glucose, and glucagon provoked GH and insulin secretory responses without affecting glucose or FFA levels [24].
  • The sensitivity of the secretory process of antibody-synthesizing cells to microtubule-binding drugs, colchicine and vinblastine sulfate, was studied [25].
  • The latter may result not only from the depression of C3 levels but also from the biologic activities of C cleavage products some of which modulate the secretory functions and state of activation of macrophages [26].

Physical interactions of LOC443338


Regulatory relationships of LOC443338

  • Taken together, these findings are consistent with a putative role of prolactin and/or related molecules in the regulation of the proliferation of the glandular compartment and/or in the control of the secretory activity of the endometrium [28].
  • During mid-pregnancy, the mononuclear trophectodermal cells produce GH that can also act on a progestinized uterus to stimulate GE hypertrophy and secretory function [29].

Other interactions of LOC443338


Analytical, diagnostic and therapeutic context of LOC443338

  • The intracellular orientation of apoB in the secretory pathway was confirmed by immunocytochemistry using antibodies recognizing specific domains of apoB in streptolysin-O (STP-O)- and saponin-permeabilized HepG2 cells [22].
  • It appears that correction of the anemia in hemodialysis patients with rHu-EPO can partly correct perturbations in the GH secretory axis but may lead to new abnormalities in the CRH-ACTH axis [35].
  • Although castration cells existed in the pituitary of rats which produced antibody to LHRH by active immunization, these cells were markedly degranulated, and secretory granules were scarce in the cytoplasm [36].
  • 3. Antral pouch perfusions with lignocaine (2%) reduced fundic pouch resting secretion to about 60% of control values but did not block secretory responses to feeding [37].
  • Sheep adenohypophyses were fractionated by differential and sucrose-density-gradient centrifugation to yield a granule fraction enriched for luteinizing-hormone (lutropin)-containing secretory granules [38].


  1. Isolation and functional characterization of human intestinal mucosal lymphoid cells. Bull, D.M., Bookman, M.A. J. Clin. Invest. (1977) [Pubmed]
  2. The liver and IgA: immunological, cell biological and clinical implications. Brown, W.R., Kloppel, T.M. Hepatology (1989) [Pubmed]
  3. Reconstitution of ceruloplasmin by the Cu(I)-glutathione complex. Evidence for a role of Mg2+ and ATP. Musci, G., Di Marco, S., Bellenchi, G.C., Calabrese, L. J. Biol. Chem. (1996) [Pubmed]
  4. Adrenal secretion of glucocorticoids during hypoxemia in fetal sheep. Jackson, B.T., Morrison, S.H., Cohn, H.E., Piasecki, G.J. Endocrinology (1989) [Pubmed]
  5. A mammalian cytochrome fused to a chloroplast transit peptide is a functional haemoprotein and is imported into isolated chloroplasts. Liu, Y.Y., Kaderbhai, N., Kaderbhai, M.A. Biochem. J. (2000) [Pubmed]
  6. Energy contributions of volatile fatty acids from the gastrointestinal tract in various species. Bergman, E.N. Physiol. Rev. (1990) [Pubmed]
  7. Uterine luteolytic hormone: a physiological role for prostaglandin F2alpha. Horton, E.W., Poyser, N.L. Physiol. Rev. (1976) [Pubmed]
  8. Exo1 and Exo2 proteins stimulate calcium-dependent exocytosis in permeabilized adrenal chromaffin cells. Morgan, A., Burgoyne, R.D. Nature (1992) [Pubmed]
  9. Interferon-like sequence of ovine trophoblast protein secreted by embryonic trophectoderm. Imakawa, K., Anthony, R.V., Kazemi, M., Marotti, K.R., Polites, H.G., Roberts, R.M. Nature (1987) [Pubmed]
  10. Abrogation of oral tolerance by contrasuppressor T cells suggests the presence of regulatory T-cell networks in the mucosal immune system. Suzuki, I., Kiyono, H., Kitamura, K., Green, D.R., McGhee, J.R. Nature (1986) [Pubmed]
  11. The effects of chronically elevated plasma cortisol on the bioactive and immunoreactive corticotropin secretory responses to hemorrhage in the fetal sheep at 0.70 gestation. Zehnder, T.J., Valego, N.K., Rose, J.C. Am. J. Obstet. Gynecol. (1994) [Pubmed]
  12. Oestrus ovis (Diptera: Oestridae): effects of larval excretory/secretory products on nitric oxide production by murine RAW 264.7 macrophages. Tabouret, G., Vouldoukis, I., Duranton, C., Prevot, F., Bergeaud, J.P., Dorchies, P., Mazier, D., Jacquiet, P. Parasite Immunol. (2001) [Pubmed]
  13. Anti-nutritional factors of Datura in feedstuffs. Piva, G., Piva, A. Nat. Toxins (1995) [Pubmed]
  14. The non-neurogenic catecholamine response of the fetal adrenal to hypoxia is dependent on activation of voltage sensitive Ca2+ channels. Adams, M.B., Simonetta, G., McMillen, I.C. Brain Res. Dev. Brain Res. (1996) [Pubmed]
  15. Selective cloning of cDNA for secretory proteins of early embryos. Identification of a transiently expressed kunitz domain protein from preimplantation sheep trophoblast. Kramer, K.K., Duffy, J.Y., Klemann, S.W., Bixby, J.A., Low, B.G., Pope, W.F., Roberts, R.M. J. Biol. Chem. (1994) [Pubmed]
  16. Plasma cells and epithelial immunoglobulins in the mouse mammary gland during pregnancy and lactation. Weisz-Carrington, P., Roux, M.E., Lamm, M.E. J. Immunol. (1977) [Pubmed]
  17. Immunoregulation of localized and disseminated murine myeloma: antigen-specific regulation of MOPC-315 stem cell proliferation and secretory cell differentiation. Rohrer, J.W., Lynch, R.G. J. Immunol. (1979) [Pubmed]
  18. Enrichment of epidermal Langerhans cells by immunoadsorption to Staphylococcus aureus cells. Schuler, G., Auböck, J., Linert, J. J. Immunol. (1983) [Pubmed]
  19. Macrophage plasma membrane and secretory properties in murine malaria. Effects of Plasmodium yoelii blood-stage infection on macrophages in liver, spleen, and blood. Lee, S.H., Crocker, P., Gordon, S. J. Exp. Med. (1986) [Pubmed]
  20. Involvement of immunoglobulin E in the secretory processes of alveolar macrophages from asthmatic patients. Joseph, M., Tonnel, A.B., Torpier, G., Capron, A., Arnoux, B., Benveniste, J. J. Clin. Invest. (1983) [Pubmed]
  21. Thyrotropin induces the acidification of the secretory granules of parafollicular cells by increasing the chloride conductance of the granular membrane. Barasch, J., Gershon, M.D., Nunez, E.A., Tamir, H., al-Awqati, Q. J. Cell Biol. (1988) [Pubmed]
  22. Identification of two regions in apolipoprotein B100 that are exposed on the cytosolic side of the endoplasmic reticulum membrane. Du, X., Stoops, J.D., Mertz, J.R., Stanley, C.M., Dixon, J.L. J. Cell Biol. (1998) [Pubmed]
  23. Somatic hypermutation of the new antigen receptor gene (NAR) in the nurse shark does not generate the repertoire: possible role in antigen-driven reactions in the absence of germinal centers. Diaz, M., Greenberg, A.S., Flajnik, M.F. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  24. Studies on growth hormone secretion. VII. Effects of somatostatin on plasma GH, insulin, and glucagon in sheep. Bryce, D., Yeh, M., Funderburk, C., Todd, H., Hertelendy, F. Diabetes (1975) [Pubmed]
  25. In vivo and in vitro effects of colchicine and vinblastine on the secretory process of antibody-producing cells. Antoine, J.C., Maurice, M., Feldmann, G., Avrameas, S. J. Immunol. (1980) [Pubmed]
  26. Studies of immunosuppression by cobra venom factor. I. On early IgG and IgM responses to sheep erythrocytes and DNP-protein conjugates. Martinelli, G.P., Matsuda, T., Osler, A.G. J. Immunol. (1978) [Pubmed]
  27. Characterization of the gene encoding ovine beta-lactoglobulin. Similarity to the genes for retinol binding protein and other secretory proteins. Ali, S., Clark, A.J. J. Mol. Biol. (1988) [Pubmed]
  28. Cellular localization and evolution of prolactin receptor mRNA in ovine endometrium during pregnancy. Cassy, S., Charlier, M., Guillomot, M., Pessemesse, L., Djiane, J. FEBS Lett. (1999) [Pubmed]
  29. Biology of progesterone action during pregnancy recognition and maintenance of pregnancy. Spencer, T.E., Bazer, F.W. Front. Biosci. (2002) [Pubmed]
  30. Molecular cloning of an ovine ovarian tissue inhibitor of metalloproteinases: ontogeny of messenger ribonucleic acid expression and in situ localization within preovulatory follicles and luteal tissue. Smith, G.W., Goetz, T.L., Anthony, R.V., Smith, M.F. Endocrinology (1994) [Pubmed]
  31. Osteopontin is synthesized by uterine glands and a 45-kDa cleavage fragment is localized at the uterine-placental interface throughout ovine pregnancy. Johnson, G.A., Burghardt, R.C., Joyce, M.M., Spencer, T.E., Bazer, F.W., Gray, C.A., Pfarrer, C. Biol. Reprod. (2003) [Pubmed]
  32. Surfactant metabolism. Ikegami, M., Jobe, A.H. Semin. Perinatol. (1993) [Pubmed]
  33. Effects of pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal polypeptide (VIP) on hormone secretion from sheep pituitary cells in vitro. Sawangjaroen, K., Anderson, S.T., Curlewis, J.D. J. Neuroendocrinol. (1997) [Pubmed]
  34. Postpartum uterine involution in sheep: histoarchitecture and changes in endometrial gene expression. Gray, C.A., Stewart, M.D., Johnson, G.A., Spencer, T.E. Reproduction (2003) [Pubmed]
  35. The effects of corticotropin and growth hormone releasing hormones on their respective secretory axes in chronic hemodialysis patients before and after correction of anemia with recombinant human erythropoietin. Ramirez, G., Bittle, P.A., Sanders, H., Rabb, H.A., Bercu, B.B. J. Clin. Endocrinol. Metab. (1994) [Pubmed]
  36. Effect of active and passive immunization with luteinizing hormone-releasing hormone on serum luteinizing hormone and follicle-stimulating hormone levels and the ultrastructure of the pituitary gonadotrophs in castrated male rats. Arimura, A., Shino, M., de la Cruz, K.G., Rennels, E.G., Schally, A.V. Endocrinology (1976) [Pubmed]
  37. Acid and pepsin secretion of separated gastric pouches during perfusion of antral pouches with cholinergic stimulating and blocking agents and lignocaine. McLeay, L.M., Titchen, D.A. J. Physiol. (Lond.) (1977) [Pubmed]
  38. Protein kinase C and an endogenous substrate associated with adenohypophyseal secretory granules. Turgeon, J.L., Cooper, R.H. Biochem. J. (1986) [Pubmed]
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