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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Prednisolone prevents transient ischemia-induced cochlear damage in gerbils.

CONCLUSIONS: Prednisolone protects against inner ear damage, even when administered after ischemic injury in Mongolian gerbils. OBJECTIVE: The effect of prednisolone on ischemia-induced cochlear damage was investigated in Mongolian gerbils. MATERIALS AND METHODS: The bilateral vertebral arteries were occluded for 15 min to transiently induce cochlear ischemia, followed by an intraperitoneal injection of prednisolone (1 mg/kg) or physiological saline (control). Sequential changes in hearing were evaluated by recording the auditory brainstem response (ABR) before and at 1, 4, and 7 days after treatment. In our histologic analysis, the numbers of dead and intact inner hair cells (IHCs) were counted in specimens stained with rhodamine-phalloidin. RESULTS: In control animals, transient ischemia increased the ABR threshold (24.2 +/- 8.6 dB) within 7 days of treatment, whereas prednisolone-treated animals exhibited a threshold of 14.2 +/- 9.2 dB. Furthermore, the percent IHC loss at the basal turn of the cochlea was 26.5 +/- 11.4% in control animals compared with 5.3 +/- 3.0% in the prednisolone-treated group.[1]

References

  1. Prednisolone prevents transient ischemia-induced cochlear damage in gerbils. Maetani, T., Hyodo, J., Takeda, S., Hakuba, N., Kiyofumi, G. Acta. Otolaryngol. Suppl (2009) [Pubmed]
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