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MeSH Review

Gerbillinae

 
 
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Disease relevance of Gerbillinae

 

Psychiatry related information on Gerbillinae

  • Infusion of EPO into the lateral ventricles of gerbils prevented ischemia-induced learning disability and rescued hippocampal CA1 neurons from lethal ischemic damage [6].
  • METHODS: Under ether anesthesia, gerbils with sham operation (S group, n = 8) and those with pretreatment consisting of BCO for 2 minutes, twice at 3 days and 2 days earlier (T group, n = 8), were again subjected to BCO for 5 minutes [7].
  • Given i.c.v., senktide (0.5-2 micrograms) and (MePhe7)neurokinin B (1-10 micrograms), another NK3 receptor agonist, reduced exploratory behaviour in gerbils in a dose-dependent manner (2 micrograms of senktide producing a 50% reduction of locomotor activity and rearing) [8].
  • Diazepam and nicotine increase social interaction in gerbils: a test for anxiolytic action [9].
  • Ginsenoside Rb1 significantly prolonged the response latency of ischemic gerbils and rescued a significant number of ischemic CA1 pyramidal neurons, whereas ginsenosides Rg1 and Ro were ineffective [10].
 

High impact information on Gerbillinae

  • Methyl 4,6-dichloro-4,6-dideoxy-alpha-D-galactopyranoside: an inhibitor of sweet taste responses in gerbils [11].
  • No ulcer was found in the gerbils infected with the cagE mutant (0/27) or in controls (0/27) [12].
  • However, IL-3 infusion prevented the decrease in Bcl-xL protein expression in the CA1 field of ischemic gerbils [13].
  • In iron-dosed gerbils on the vitamin E-enriched diet for 4 mo, in spite of a severe liver iron burden, a normal lobular architecture was found, with a dramatic decrease of collagen mRNA accumulation and collagen deposition [1].
  • Finally, gerbils treated with DMTU or tungsten all survived, while greater than 60% of gerbils treated with urea, allopurinol, or saline died by 48 h after temporary unilateral carotid artery occlusion and reperfusion [14].
 

Chemical compound and disease context of Gerbillinae

 

Biological context of Gerbillinae

 

Anatomical context of Gerbillinae

 

Associations of Gerbillinae with chemical compounds

  • Mongolian gerbils (Meriones unguiculatus) were given an sc injection (40 mg/kg body wt) of N-ethyl-N-nitrosourea [(ENU) CAS: 759-73-9] on postnatal day 1 (group I) or day 29 (group II) [2].
  • To identify which chemical gradient guides the bacteria within the mucus layer, combinations of luminal perfusion, dialysis, and ventilation were used to modify or invert transmucus gradients in anaesthetized Helicobacter-infected mice and Mongolian gerbils [30].
  • Gerbils (6-16 animals per dietary group) were fed purified diets (21 with 0.01 to 0.08% cholesterol and 38 cholesterol-free) for 4-week periods [31].
  • Delayed pentobarbital administration limits ischemic brain damage in gerbils [32].
  • In gerbils consuming cholesterol-supplemented diets, 87% of the observed variation in TC could be accounted for by a regression equation that included 14:0, palmitic acid (16:0), and a log function of 18:2 plus dietary cholesterol itself [31].
 

Gene context of Gerbillinae

  • This astroglial response was higher in the grafted side than in the contralateral side in ischemic gerbils, but no differences were seen between BDNF-producing and non-BDNF-producing grafts [33].
  • IPF1/PDX1 deficiency and beta-cell dysfunction in Psammomys obesus, an animal With type 2 diabetes [34].
  • Tanis is a recently described protein reported to be a putative receptor for serum amyloid A and found to be dysregulated with diabetes in the Israeli sand rat Psamommys obesus [35].
  • In accordance with this, we detected decreased 125I-labeled insulin binding, probably reflecting a downregulation of IR numbers, in skeletal muscle of Psammomys animals from the DP line [36].
  • Significantly reduced IFN-gamma and IL-12p40 responses were observed in male gerbils infected with H pylori, but epithelial proliferative and apoptotic responses were comparable to those of females [37].
 

Analytical, diagnostic and therapeutic context of Gerbillinae

References

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  14. Xanthine oxidase-derived hydrogen peroxide contributes to ischemia reperfusion-induced edema in gerbil brains. Patt, A., Harken, A.H., Burton, L.K., Rodell, T.C., Piermattei, D., Schorr, W.J., Parker, N.B., Berger, E.M., Horesh, I.R., Terada, L.S. J. Clin. Invest. (1988) [Pubmed]
  15. Hyperinsulinemia induces a reversible impairment in insulin receptor function leading to diabetes in the sand rat model of non-insulin-dependent diabetes mellitus. Kanety, H., Moshe, S., Shafrir, E., Lunenfeld, B., Karasik, A. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
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  20. Benzodiazepine/gamma-aminobutyric acid receptor deficit in the midbrain of the seizure-susceptible gerbil. Olsen, R.W., Wamsley, J.K., McCabe, R.T., Lee, R.J., Lomax, P. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  21. DNA methylation by dimethylnitrosamine in the Mongolian gerbil (Meriones unguiculatus): indications of a deficient, noninducible hepatic repair system for O6-methylguanine. Bamborschke, S., O'Connor, P.J., Margison, G.P., Kleihues, P., Maru, G.B. Cancer Res. (1983) [Pubmed]
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  23. Effects of tirilazad mesylate on postischemic brain lipid peroxidation and recovery of extracellular calcium in gerbils. Hall, E.D., Pazara, K.E., Braughler, J.M. Stroke (1991) [Pubmed]
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  34. IPF1/PDX1 deficiency and beta-cell dysfunction in Psammomys obesus, an animal With type 2 diabetes. Leibowitz, G., Ferber, S., Apelqvist A, n.u.l.l., Edlund, H., Gross, D.J., Cerasi, E., Melloul, D., Kaiser, N. Diabetes (2001) [Pubmed]
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