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Disease relevance of Gerbillinae


Psychiatry related information on Gerbillinae

  • Infusion of EPO into the lateral ventricles of gerbils prevented ischemia-induced learning disability and rescued hippocampal CA1 neurons from lethal ischemic damage [6].
  • METHODS: Under ether anesthesia, gerbils with sham operation (S group, n = 8) and those with pretreatment consisting of BCO for 2 minutes, twice at 3 days and 2 days earlier (T group, n = 8), were again subjected to BCO for 5 minutes [7].
  • Given i.c.v., senktide (0.5-2 micrograms) and (MePhe7)neurokinin B (1-10 micrograms), another NK3 receptor agonist, reduced exploratory behaviour in gerbils in a dose-dependent manner (2 micrograms of senktide producing a 50% reduction of locomotor activity and rearing) [8].
  • Diazepam and nicotine increase social interaction in gerbils: a test for anxiolytic action [9].
  • Ginsenoside Rb1 significantly prolonged the response latency of ischemic gerbils and rescued a significant number of ischemic CA1 pyramidal neurons, whereas ginsenosides Rg1 and Ro were ineffective [10].

High impact information on Gerbillinae

  • Methyl 4,6-dichloro-4,6-dideoxy-alpha-D-galactopyranoside: an inhibitor of sweet taste responses in gerbils [11].
  • No ulcer was found in the gerbils infected with the cagE mutant (0/27) or in controls (0/27) [12].
  • However, IL-3 infusion prevented the decrease in Bcl-xL protein expression in the CA1 field of ischemic gerbils [13].
  • In iron-dosed gerbils on the vitamin E-enriched diet for 4 mo, in spite of a severe liver iron burden, a normal lobular architecture was found, with a dramatic decrease of collagen mRNA accumulation and collagen deposition [1].
  • Finally, gerbils treated with DMTU or tungsten all survived, while greater than 60% of gerbils treated with urea, allopurinol, or saline died by 48 h after temporary unilateral carotid artery occlusion and reperfusion [14].

Chemical compound and disease context of Gerbillinae


Biological context of Gerbillinae


Anatomical context of Gerbillinae


Associations of Gerbillinae with chemical compounds

  • Mongolian gerbils (Meriones unguiculatus) were given an sc injection (40 mg/kg body wt) of N-ethyl-N-nitrosourea [(ENU) CAS: 759-73-9] on postnatal day 1 (group I) or day 29 (group II) [2].
  • To identify which chemical gradient guides the bacteria within the mucus layer, combinations of luminal perfusion, dialysis, and ventilation were used to modify or invert transmucus gradients in anaesthetized Helicobacter-infected mice and Mongolian gerbils [30].
  • Gerbils (6-16 animals per dietary group) were fed purified diets (21 with 0.01 to 0.08% cholesterol and 38 cholesterol-free) for 4-week periods [31].
  • Delayed pentobarbital administration limits ischemic brain damage in gerbils [32].
  • In gerbils consuming cholesterol-supplemented diets, 87% of the observed variation in TC could be accounted for by a regression equation that included 14:0, palmitic acid (16:0), and a log function of 18:2 plus dietary cholesterol itself [31].

Gene context of Gerbillinae

  • This astroglial response was higher in the grafted side than in the contralateral side in ischemic gerbils, but no differences were seen between BDNF-producing and non-BDNF-producing grafts [33].
  • IPF1/PDX1 deficiency and beta-cell dysfunction in Psammomys obesus, an animal With type 2 diabetes [34].
  • Tanis is a recently described protein reported to be a putative receptor for serum amyloid A and found to be dysregulated with diabetes in the Israeli sand rat Psamommys obesus [35].
  • In accordance with this, we detected decreased 125I-labeled insulin binding, probably reflecting a downregulation of IR numbers, in skeletal muscle of Psammomys animals from the DP line [36].
  • Significantly reduced IFN-gamma and IL-12p40 responses were observed in male gerbils infected with H pylori, but epithelial proliferative and apoptotic responses were comparable to those of females [37].

Analytical, diagnostic and therapeutic context of Gerbillinae


  1. Molecular and cellular aspects of iron-induced hepatic cirrhosis in rodents. Pietrangelo, A., Gualdi, R., Casalgrandi, G., Montosi, G., Ventura, E. J. Clin. Invest. (1995) [Pubmed]
  2. Induction of gliomas in Mongolian gerbils (Meriones unguiculatus) following neonatal administration of N-ethyl-N-nitrosourea. Naito, M., Aoyama, H., Fujioka, Y., Ito, A. J. Natl. Cancer Inst. (1985) [Pubmed]
  3. Selective induction of melanomas in gerbils (Meriones unguiculatus) following postnatal administration of N-ethyl-N-nitrosourea. Kleihues, P., Bücheler, J., Riede, U.N. J. Natl. Cancer Inst. (1978) [Pubmed]
  4. Helicobacter pylori alters gastric epithelial cell cycle events and gastrin secretion in Mongolian gerbils. Peek, R.M., Wirth, H.P., Moss, S.F., Yang, M., Abdalla, A.M., Tham, K.T., Zhang, T., Tang, L.H., Modlin, I.M., Blaser, M.J. Gastroenterology (2000) [Pubmed]
  5. Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia. Yrjänheikki, J., Keinänen, R., Pellikka, M., Hökfelt, T., Koistinaho, J. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  6. In vivo evidence that erythropoietin protects neurons from ischemic damage. Sakanaka, M., Wen, T.C., Matsuda, S., Masuda, S., Morishita, E., Nagao, M., Sasaki, R. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  7. A near-infrared spectroscopic study of cerebral ischemia and ischemic tolerance in gerbils. Li, J.Y., Ueda, H., Seiyama, A., Nakano, M., Matsumoto, M., Yanagihara, T. Stroke (1997) [Pubmed]
  8. Electrophysiological, behavioural and biochemical evidence for activation of brain noradrenergic systems following neurokinin NK3 receptor stimulation. Jung, M., Michaud, J.C., Steinberg, R., Barnouin, M.C., Hayar, A., Mons, G., Souilhac, J., Emonds-Alt, X., Soubrié, P., Le Fur, G. Neuroscience (1996) [Pubmed]
  9. Diazepam and nicotine increase social interaction in gerbils: a test for anxiolytic action. File, S.E., Cheeta, S., Akanezi, C. Brain Res. (2001) [Pubmed]
  10. Ginseng root prevents learning disability and neuronal loss in gerbils with 5-minute forebrain ischemia. Wen, T.C., Yoshimura, H., Matsuda, S., Lim, J.H., Sakanaka, M. Acta Neuropathol. (1996) [Pubmed]
  11. Methyl 4,6-dichloro-4,6-dideoxy-alpha-D-galactopyranoside: an inhibitor of sweet taste responses in gerbils. Jakinovich, W. Science (1983) [Pubmed]
  12. Virulence factors of Helicobacter pylori responsible for gastric diseases in Mongolian gerbil. Ogura, K., Maeda, S., Nakao, M., Watanabe, T., Tada, M., Kyutoku, T., Yoshida, H., Shiratori, Y., Omata, M. J. Exp. Med. (2000) [Pubmed]
  13. Interleukin 3 prevents delayed neuronal death in the hippocampal CA1 field. Wen, T.C., Tanaka, J., Peng, H., Desaki, J., Matsuda, S., Maeda, N., Fujita, H., Sato, K., Sakanaka, M. J. Exp. Med. (1998) [Pubmed]
  14. Xanthine oxidase-derived hydrogen peroxide contributes to ischemia reperfusion-induced edema in gerbil brains. Patt, A., Harken, A.H., Burton, L.K., Rodell, T.C., Piermattei, D., Schorr, W.J., Parker, N.B., Berger, E.M., Horesh, I.R., Terada, L.S. J. Clin. Invest. (1988) [Pubmed]
  15. Hyperinsulinemia induces a reversible impairment in insulin receptor function leading to diabetes in the sand rat model of non-insulin-dependent diabetes mellitus. Kanety, H., Moshe, S., Shafrir, E., Lunenfeld, B., Karasik, A. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  16. Aurintricarboxylic acid prevents GLUR2 mRNA down-regulation and delayed neurodegeneration in hippocampal CA1 neurons of gerbil after global ischemia. Aronica, E.M., Gorter, J.A., Grooms, S., Kessler, J.A., Bennett, M.V., Zukin, R.S., Rosenbaum, D.M. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  17. Systemic administration of MK-801 protects against ischemia-induced hippocampal neurodegeneration in the gerbil. Gill, R., Foster, A.C., Woodruff, G.N. J. Neurosci. (1987) [Pubmed]
  18. Measurement of regional N-acetylaspartate after transient global ischemia in gerbils with and without ischemic tolerance: an index of neuronal survival. Nakano, M., Ueda, H., Li, J.Y., Matsumoto, M., Yanagihara, T. Ann. Neurol. (1998) [Pubmed]
  19. Rapid induction of hepatic fibrosis in the gerbil after the parenteral administration of iron-dextran complex. Carthew, P., Edwards, R.E., Smith, A.G., Dorman, B., Francis, J.E. Hepatology (1991) [Pubmed]
  20. Benzodiazepine/gamma-aminobutyric acid receptor deficit in the midbrain of the seizure-susceptible gerbil. Olsen, R.W., Wamsley, J.K., McCabe, R.T., Lee, R.J., Lomax, P. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  21. DNA methylation by dimethylnitrosamine in the Mongolian gerbil (Meriones unguiculatus): indications of a deficient, noninducible hepatic repair system for O6-methylguanine. Bamborschke, S., O'Connor, P.J., Margison, G.P., Kleihues, P., Maru, G.B. Cancer Res. (1983) [Pubmed]
  22. Hypolipidemic, antiobesity, and hypoglycemic-hypoinsulinemic effects of beta,beta'-methyl-substituted hexadecanedioic acid in sand rats. Tzur, R., Rose-Kahn, G., Adler, J.H., Bar-Tana, J. Diabetes (1988) [Pubmed]
  23. Effects of tirilazad mesylate on postischemic brain lipid peroxidation and recovery of extracellular calcium in gerbils. Hall, E.D., Pazara, K.E., Braughler, J.M. Stroke (1991) [Pubmed]
  24. The protective effect of L-threo-3,4-dihydroxyphenylserine on ischemic hippocampal neuronal death in gerbils. Lee, T.H., Abe, K., Aoki, M., Nakamura, M., Kogure, K., Itoyama, Y. Stroke (1994) [Pubmed]
  25. Specific carcinogenic effect of N-methyl-N-nitrosourea on the midventral sebaceous gland of the gerbil (Meriones unguiculatus). Haas, H., Hilfrich, J., Kmoch, N., Mohr, U. J. Natl. Cancer Inst. (1975) [Pubmed]
  26. Helicobacter pylori cag-type IV secretion system facilitates corpus colonization to induce precancerous conditions in Mongolian gerbils. Rieder, G., Merchant, J.L., Haas, R. Gastroenterology (2005) [Pubmed]
  27. Cerebral microvessel 2-deoxy-D-glucose uptake during ischemia-induced seizures. Nell, J.H., Welch, K.M. Ann. Neurol. (1980) [Pubmed]
  28. Testing the disinhibition hypothesis of epileptogenesis in vivo and during spontaneous seizures. Buckmaster, P.S., Jongen-Rêlo, A.L., Davari, S.B., Wong, E.H. J. Neurosci. (2000) [Pubmed]
  29. Complete life cycle of the canid tapeworm, Echinococcus multilocularis, in laboratory rodents. Kamiya, M., Sato, H. FASEB J. (1990) [Pubmed]
  30. The spatial orientation of Helicobacter pylori in the gastric mucus. Schreiber, S., Konradt, M., Groll, C., Scheid, P., Hanauer, G., Werling, H.O., Josenhans, C., Suerbaum, S. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  31. Dietary myristic, palmitic, and linoleic acids modulate cholesterolemia in gerbils. Pronczuk, A., Khosla, P., Hayes, K.C. FASEB J. (1994) [Pubmed]
  32. Delayed pentobarbital administration limits ischemic brain damage in gerbils. Levy, D.E., Brierley, J.B. Ann. Neurol. (1979) [Pubmed]
  33. BDNF up-regulates TrkB protein and prevents the death of CA1 neurons following transient forebrain ischemia. Ferrer, I., Ballabriga, J., Martí, E., Pérez, E., Alberch, J., Arenas, E. Brain Pathol. (1998) [Pubmed]
  34. IPF1/PDX1 deficiency and beta-cell dysfunction in Psammomys obesus, an animal With type 2 diabetes. Leibowitz, G., Ferber, S., Apelqvist A, n.u.l.l., Edlund, H., Gross, D.J., Cerasi, E., Melloul, D., Kaiser, N. Diabetes (2001) [Pubmed]
  35. Relationship between serum amyloid A level and Tanis/SelS mRNA expression in skeletal muscle and adipose tissue from healthy and type 2 diabetic subjects. Karlsson, H.K., Tsuchida, H., Lake, S., Koistinen, H.A., Krook, A. Diabetes (2004) [Pubmed]
  36. Cellular mechanism of nutritionally induced insulin resistance in Psammomys obesus: overexpression of protein kinase Cepsilon in skeletal muscle precedes the onset of hyperinsulinemia and hyperglycemia. Ikeda, Y., Olsen, G.S., Ziv, E., Hansen, L.L., Busch, A.K., Hansen, B.F., Shafrir, E., Mosthaf-Seedorf, L. Diabetes (2001) [Pubmed]
  37. Gastric mucosal cytokine and epithelial cell responses to Helicobacter pylori infection in Mongolian gerbils. Crabtree, J.E., Court, M., Aboshkiwa, M.A., Jeremy, A.H., Dixon, M.F., Robinson, P.A. J. Pathol. (2004) [Pubmed]
  38. Induction of protection against Brugia malayi infection in jirds by microfilarial antigens. Kazura, J.W., Cicirello, H., McCall, J.W. J. Immunol. (1986) [Pubmed]
  39. Development of macroangiopathy in sand rats (Psammomys obesus), an animal model of non-insulin-dependent diabetes mellitus: effect of gliclazide. Marquié, G., Hadjiisky, P., Arnaud, O., Duhault, J. Am. J. Med. (1991) [Pubmed]
  40. A cross-sectional and short-term longitudinal characterisation of NIDDM in Psammomys obesus. Barnett, M., Collier, G.R., Collier, F.M., Zimmet, P., O'Dea, K. Diabetologia (1994) [Pubmed]
  41. Sympathectomy, which induces membranous bone remodeling, has no effect on endochondral long bone remodeling in vivo. Sherman, B.E., Chole, R.A. J. Bone Miner. Res. (2000) [Pubmed]
  42. Angiotensin II decreases mortality rate in gerbils with unilateral carotid ligation. Fernandez, L.A., Spencer, D.D., Kaczmar, T. Stroke (1986) [Pubmed]
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