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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Translocation of the yeast dolichol-phosphate-mannose synthase into microsomal membranes.

Dolichol-phosphate-mannose synthase catalyzes the formation of Dolichol-phosphate-mannose from Dolichol-phosphate and GDP-mannose. Analysis of the primary amino acid sequence of the yeast enzyme predicts a luminal orientation of the enzyme in the endoplasmic reticulum. We analysed the translocation of the Dolichol-phosphate-mannose synthase into dog pancreatic microsomal membranes: resistance to proteolytic attack provides evidence of its luminal orientation and asks for a reevaluation of the topology of the reaction.[1]


  1. Translocation of the yeast dolichol-phosphate-mannose synthase into microsomal membranes. Déglon, N., Krapp, A., Bron, C., Fasel, N. Biochem. Biophys. Res. Commun. (1991) [Pubmed]
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