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Chemical Compound Review

AG-J-33010     3,8-dimethyldec-7- enoxyphosphonic acid

Synonyms: CTK6C6341, AC1L19S2, 3,8-dimethyldec-7-enyl dihydrogen phosphate
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Disease relevance of dolichyl-phosphate


High impact information on dolichyl-phosphate


Chemical compound and disease context of dolichyl-phosphate


Biological context of dolichyl-phosphate


Anatomical context of dolichyl-phosphate


Associations of dolichyl-phosphate with other chemical compounds


Gene context of dolichyl-phosphate


Analytical, diagnostic and therapeutic context of dolichyl-phosphate


  1. Cytidine 5'-triphosphate-dependent dolichol kinase and dolichol phosphatase activities and levels of dolichyl phosphate in microsomal fractions from highly differentiated human hepatomas. Eggens, I., Ericsson, J., Tollbom, O. Cancer Res. (1988) [Pubmed]
  2. Expression of the insulin-like growth factor 1 receptor (IGF-1R) in breast cancer cells: evidence for a regulatory role of dolichyl phosphate in the transition from an intracellular to an extracellular IGF-1 pathway. Dricu, A., Kanter, L., Wang, M., Nilsson, G., Hjertman, M., Wejde, J., Larsson, O. Glycobiology (1999) [Pubmed]
  3. Synergistic effect of dolichyl phosphate and human recombinant granulocyte colony-stimulating factor on recovery from neutropenia in mice treated with anti-cancer drugs. Shimamura, M., Takigawa, T., Urabe, A., Okabe, T., Souza, L.M., Takaku, F. Exp. Hematol. (1988) [Pubmed]
  4. A gene encoding a homologue of dolichol phosphate-beta-D-mannose synthase is required for infection of Streptomyces coelicolor A3(2) by phage (phi)C31. Cowlishaw, D.A., Smith, M.C. J. Bacteriol. (2002) [Pubmed]
  5. Carbohydrate deficient glycoprotein syndrome type IV: deficiency of dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase. Körner, C., Knauer, R., Stephani, U., Marquardt, T., Lehle, L., von Figura, K. EMBO J. (1999) [Pubmed]
  6. Evidence that free GPI glycolipids are essential for growth of Leishmania mexicana. Ilgoutz, S.C., Zawadzki, J.L., Ralton, J.E., McConville, M.J. EMBO J. (1999) [Pubmed]
  7. DPM2 regulates biosynthesis of dolichol phosphate-mannose in mammalian cells: correct subcellular localization and stabilization of DPM1, and binding of dolichol phosphate. Maeda, Y., Tomita, S., Watanabe, R., Ohishi, K., Kinoshita, T. EMBO J. (1998) [Pubmed]
  8. Yeast Wbp1p and Swp1p form a protein complex essential for oligosaccharyl transferase activity. te Heesen, S., Knauer, R., Lehle, L., Aebi, M. EMBO J. (1993) [Pubmed]
  9. A defect in dolichol phosphate biosynthesis causes a new inherited disorder with death in early infancy. Kranz, C., Jungeblut, C., Denecke, J., Erlekotte, A., Sohlbach, C., Debus, V., Kehl, H.G., Harms, E., Reith, A., Reichel, S., Grobe, H., Hammersen, G., Schwarzer, U., Marquardt, T. Am. J. Hum. Genet. (2007) [Pubmed]
  10. Retinyl palmitate, retinyl phosphate, and dolichyl phosphate of postnuclear membrane fraction from hepatoma, host liver, and regenerating liver: marginal vitamin A status of hepatoma tissue. De Luca, L.M., Brugh, M., Silverman-Jones, C.S. Cancer Res. (1984) [Pubmed]
  11. The subcellular localization of enzymes of dolichol metabolism in rat liver. Rupar, C.A., Rip, J.W., Chaudhary, N., Carroll, K.K. J. Biol. Chem. (1982) [Pubmed]
  12. Solubilization and characterization of the long chain prenyltransferase involved in dolichyl phosphate biosynthesis. Adair, W.L., Cafmeyer, N., Keller, R.K. J. Biol. Chem. (1984) [Pubmed]
  13. Effects of growth factors on cell cycle arrest in dolichyl phosphate-depleted cultures. Doyle, J.W., Ward-Bailey, P.F., Kandutsch, A.A. J. Cell. Physiol. (1993) [Pubmed]
  14. Investigations of the active site of Saccharomyces cerevisiae dolichyl-phosphate-mannose synthase using fluorescent labeled dolichyl-phosphate derivatives. Xing, J., Forsee, W.T., Lamani, E., Maltsev, S.D., Danilov, L.L., Shibaev, V.N., Schutzbach, J.S., Cheung, H.C., Jedrzejas, M.J. Biochemistry (2000) [Pubmed]
  15. Dolichyl phosphate-mediated mannosyl transfer through liposomal membranes. Haselbeck, A., Tanner, W. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  16. Role of dolichyl phosphate in regulation of protein glycosylation in 2-acetylaminofluorene-induced carcinogenesis in rat liver. Eggens, I., Eriksson, L.C., Chojnacki, T., Dallner, G. Cancer Res. (1984) [Pubmed]
  17. Decreased transfer of oligosaccharide from oligosaccharide-lipid to protein acceptors in regenerating rat liver. Oda-Tamai, S., Kato, S., Hara, S., Akamatsu, N. J. Biol. Chem. (1985) [Pubmed]
  18. Dolichol metabolism in rat liver. Determination of the subcellular distribution of dolichyl phosphate and its site and rate of de novo biosynthesis. Adair, W.L., Keller, R.K. J. Biol. Chem. (1982) [Pubmed]
  19. Metabolic labeling of dolichol and dolichyl phosphate in isolate hepatocytes. Ekström, T.J., Chojnacki, T., Dallner, G. J. Biol. Chem. (1984) [Pubmed]
  20. Isoprenoid biosynthesis in the retina. Quantitation of the sterol and dolichol biosynthetic pathways. Keller, R.K., Fliesler, S.J., Nellis, S.W. J. Biol. Chem. (1988) [Pubmed]
  21. A single enzyme catalyzes the synthesis of the mannosylphosphoryl derivative of dolichol and retinol in rat liver and Chinese hamster ovary cells. Stoll, J., Rosenberg, L., Carson, D.D., Lennarz, W.J., Krag, S.S. J. Biol. Chem. (1985) [Pubmed]
  22. Formation of dolichol-linked sugar intermediates during the postnatal development of skeletal muscle. Clark, G.F., Miller, K.R., Smith, P.B. J. Biol. Chem. (1983) [Pubmed]
  23. Enzymatic activities in cultured human lymphocytes that dephosphorylate dolichyl pyrophosphate and dolichyl phosphate. Wedgwood, J.F., Strominger, J.L. J. Biol. Chem. (1980) [Pubmed]
  24. A 13-amino acid peptide in three yeast glycosyltransferases may be involved in dolichol recognition. Albright, C.F., Orlean, P., Robbins, P.W. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  25. Protein glycosylation in pmt mutants of Saccharomyces cerevisiae. Influence of heterologously expressed cellobiohydrolase II of Trichoderma reesei and elevated levels of GDP-mannose and cis-prenyltransferase activity. Górka-Nieć, W., Bańkowska, R., Palamarczyk, G., Krotkiewski, H., Kruszewska, J.S. Biochim. Biophys. Acta (2007) [Pubmed]
  26. Saccharomyces cerevisiae sec59 cells are deficient in dolichol kinase activity. Heller, L., Orlean, P., Adair, W.L. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  27. Involvement of sterol carrier protein-2 in dolichol biosynthesis. Ericsson, J., Scallen, T.J., Chojnacki, T., Dallner, G. J. Biol. Chem. (1991) [Pubmed]
  28. The submicrosomal distribution of dolichyl phosphate and dolichyl phosphate phosphatase in rat liver. Rip, J.W., Chaudhary, N., Carroll, K.K. J. Biol. Chem. (1983) [Pubmed]
  29. Topographical orientation in microsomal vesicles of the N-acetylglucosaminyltransferases which catalyze the biosynthesis of N-acetylglucosaminylpyrophosphoryldolichol and N-acetylglucosaminyl-N-acetylglucosaminylpyrophosphoryldolichol. Kean, E.L. J. Biol. Chem. (1991) [Pubmed]
  30. The influence of dolichol, dolichol esters, and dolichyl phosphate on phospholipid polymorphism and fluidity in model membranes. Valtersson, C., van Duÿn, G., Verkleij, A.J., Chojnacki, T., de Kruijff, B., Dallner, G. J. Biol. Chem. (1985) [Pubmed]
  31. Depression of hepatic dolichol levels by cholesterol feeding. Kabakoff, B.D., Kandutsch, A.A. J. Lipid Res. (1987) [Pubmed]
  32. Regulatory adaptation of isoprenoid biosynthesis and the LDL receptor pathway in fibroblasts from patients with mevalonate kinase deficiency. Hoffmann, G.F., Wiesmann, U.N., Brendel, S., Keller, R.K., Gibson, K.M. Pediatr. Res. (1997) [Pubmed]
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