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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Effects of ischemia and hemoglobin on vascular function in isolated rabbit aortas.

The vascular endothelium is important in the modulation of vascular tone via production of endothelium-derived relaxing and contracting factors. The abdominal aortas of five groups of rabbits were subjected to varying lengths of ischemia (0, 1, 2, 3, or 4 hours), removed, sectioned into transverse rings, and placed in tissue baths containing Krebs' buffer at 37 degrees C and aerated with 95% O2/5% CO2. After equilibration the rings were tested for endothelium-dependent vasodilation with methacholine and nonendothelium-dependent vasodilation with nitroprusside. Endothelium-dependent relaxation as elicited by methacholine was impaired at 3 and 4 hours of ischemia but was not significantly different at 1 and 2 hours as compared to control, whereas endothelium-independent vasodilation remained normal throughout the different periods of ischemia. The addition of 1 x 10(-6) mol/L rabbit hemoglobin reduced the time needed to demonstrate significant impairment of endothelial function to 2 hours. Endothelium-independent vasodilation was not affected by hemoglobin. We conclude that hemoglobin exacerbates ischemia vascular dysfunction in the rabbit aorta.[1]


  1. Effects of ischemia and hemoglobin on vascular function in isolated rabbit aortas. Ruiz, A.J., Chan, B.B., Meyerhoefer, T.A., Buck, D.R., Farley, P.C., Flanagan, T.L., Kron, I.L. J. Vasc. Surg. (1991) [Pubmed]
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