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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Aorta


High impact information on Aorta

  • In contrast, the serotonin level in plasma from the ascending aorta did not change [6].
  • The mutant mice had five times normal plasma cholesterol, and developed foam cell-rich depositions in their proximal aortas by age 3 months [7].
  • We found decreased free nitric oxide (NO) levels in aged rat aortas, in conjunction with a sevenfold higher expression and activity of endothelial NO synthase (eNOS) [8].
  • Expression of genes that regulate regeneration of glutathione was reduced in the hAR-expressing aortas [9].
  • Ex vivo, NPY-induced aortic sprouting is markedly reduced in Y2(-/-) aortas and spontaneous sprouting is severely impaired in NPY(-/-) mice [10].

Chemical compound and disease context of Aorta


Biological context of Aorta


Anatomical context of Aorta

  • A decrease in Na(+)-K+ ATPase activity (42%; P less than 0.05), only seen in the presence of endothelium, was also observed in aortas taken directly from alloxan-induced diabetic rabbits [21].
  • Smooth muscle cells were isolated from the aortas of mice with a targeted deletion of the DDR1 gene (DDR1-null) and studied in culture using models that mimic critical steps in neointimal thickening [22].
  • Intimal Mphi isolated from human aortas likewise showed endothelial cell contact-dependent, MCSF-induced proliferation [23].
  • An abundant expression of alpha 2MR/LRP mRNA and protein was found in SMC and macrophages in both early and advanced lesions in human aortas. alpha 2MR/LRP was also present in SMC in normal aortas [24].
  • Specific imidazolone immunoreactivity was detected in nodular lesions and expanded mesangial matrix of glomeruli, and renal arteries in an advanced stage of diabetic nephropathy, as well as in atherosclerotic lesions of aortas [25].

Associations of Aorta with chemical compounds

  • A time-course study illustrated that both L- and H-ferritin mRNAs were markedly increased in aortas of rabbits after feeding with a high cholesterol diet for 6 wk, which was also the time period after which the formation of lesions became evident [26].
  • Furthermore, endothelium-dependent relaxations to calcium ionophore and acetylcholine (both 10(-10) - 10(-5) mol/liter) were also reduced in aortas from old as compared with young rats (n = 6, P < 0.05) [27].
  • The induction of hsp70 mRNA by either norepinephrine or by phorbol dibutyrate was blunted in aortas from old (24-27 mo) rats whereas c-fos responses were not diminished in the older vessels [28].
  • PGI2 synthesis in de-endothelialized aortas was determined immediately after balloon-catheter injury and at intervals of 1 h and 2, 4, 15, 35, and 70 d [29].
  • In contrast, relaxations of transgenic aorta in response to acetylcholine and sodium nitroprusside were significantly attenuated, and the reduced vascular reactivity was associated with reduced response of cGMP elevation to these agents as compared with control aortas [30].

Gene context of Aorta

  • High levels of PDE1C were found in primary cultures of SMCs derived from explants of human newborn and adult aortas, and in SMCs cultured from severe atherosclerotic lesions [31].
  • MMP-2 was increased in the diseased aortas, and TIMP-2 was abundant in normal, AOD, and AAA samples [32].
  • In the aging aortas, the expression of both eNOS and iNOS isoforms was enhanced [33].
  • En face confocal microscopy of the mouse ascending aorta and proximal arch demonstrated that VCAM-1 expression was increased on the endothelial cell surface in lesion-prone areas [34].
  • The decrease in interleukin-12 production was recapitulated in vivo in mouse aortas of the triple knockout group and was reflected in a marked decrease in interferon-gamma expression [35].

Analytical, diagnostic and therapeutic context of Aorta


  1. Th2-predominant inflammation and blockade of IFN-gamma signaling induce aneurysms in allografted aortas. Shimizu, K., Shichiri, M., Libby, P., Lee, R.T., Mitchell, R.N. J. Clin. Invest. (2004) [Pubmed]
  2. Angiotensin II-induced hypertension increases heme oxygenase-1 expression in rat aorta. Ishizaka, N., de León, H., Laursen, J.B., Fukui, T., Wilcox, J.N., De Keulenaer, G., Griendling, K.K., Alexander, R.W. Circulation (1997) [Pubmed]
  3. Effect of hypercholesterolemia on vascular reactivity in the rabbit. II. Influence of treatment with dipyridamole on endothelium-dependent and endothelium-independent responses in isolated aortas of control and hypercholesterolemic rabbits. Verbeuren, T.J., Coene, M.C., Jordaens, F.H., Van Hove, C.E., Zonnekeyn, L.L., Herman, A.G. Circ. Res. (1986) [Pubmed]
  4. Regulation of vasculogenesis and angiogenesis by EphB/ephrin-B2 signaling between endothelial cells and surrounding mesenchymal cells. Oike, Y., Ito, Y., Hamada, K., Zhang, X.Q., Miyata, K., Arai, F., Inada, T., Araki, K., Nakagata, N., Takeya, M., Kisanuki, Y.Y., Yanagisawa, M., Gale, N.W., Suda, T. Blood (2002) [Pubmed]
  5. Role of poly-ADP ribosyltransferase activation in the vascular contractile and energetic failure elicited by exogenous and endogenous nitric oxide and peroxynitrite. Szabó, C., Zingarelli, B., Salzman, A.L. Circ. Res. (1996) [Pubmed]
  6. Local effect of serotonin released during coronary angioplasty. Golino, P., Piscione, F., Benedict, C.R., Anderson, H.V., Cappelli-Bigazzi, M., Indolfi, C., Condorelli, M., Chiariello, M., Willerson, J.T. N. Engl. J. Med. (1994) [Pubmed]
  7. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Zhang, S.H., Reddick, R.L., Piedrahita, J.A., Maeda, N. Science (1992) [Pubmed]
  8. Enhanced peroxynitrite formation is associated with vascular aging. van der Loo, B., Labugger, R., Skepper, J.N., Bachschmid, M., Kilo, J., Powell, J.M., Palacios-Callender, M., Erusalimsky, J.D., Quaschning, T., Malinski, T., Gygi, D., Ullrich, V., Lüscher, T.F. J. Exp. Med. (2000) [Pubmed]
  9. Human aldose reductase expression accelerates diabetic atherosclerosis in transgenic mice. Vikramadithyan, R.K., Hu, Y., Noh, H.L., Liang, C.P., Hallam, K., Tall, A.R., Ramasamy, R., Goldberg, I.J. J. Clin. Invest. (2005) [Pubmed]
  10. Neuropeptide Y induces ischemic angiogenesis and restores function of ischemic skeletal muscles. Lee, E.W., Michalkiewicz, M., Kitlinska, J., Kalezic, I., Switalska, H., Yoo, P., Sangkharat, A., Ji, H., Li, L., Michalkiewicz, T., Ljubisavljevic, M., Johansson, H., Grant, D.S., Zukowska, Z. J. Clin. Invest. (2003) [Pubmed]
  11. Superoxide production in vascular smooth muscle contributes to oxidative stress and impaired relaxation in atherosclerosis. Miller, F.J., Gutterman, D.D., Rios, C.D., Heistad, D.D., Davidson, B.L. Circ. Res. (1998) [Pubmed]
  12. Leukocyte-derived myeloperoxidase amplifies high-glucose--induced endothelial dysfunction through interaction with high-glucose--stimulated, vascular non--leukocyte-derived reactive oxygen species. Zhang, C., Yang, J., Jennings, L.K. Diabetes (2004) [Pubmed]
  13. Ascending aorta distensibility abnormalities in hypertensive patients and response to nifedipine administration. Stratos, C., Stefanadis, C., Kallikazaros, I., Boudoulas, H., Toutouzas, P. Am. J. Med. (1992) [Pubmed]
  14. Biochemical investigation of possible lesions in human aorta that predispose to dissecting aneurysms: pyridinoline crosslinks. Whittle, M.A., Robins, S.P., Hasleton, P.S., Anderson, J.C. Cardiovasc. Res. (1987) [Pubmed]
  15. Inhibition of serine palmitoyltransferase activity in rabbit aorta by L-cycloserine. Williams, R.D., Sgoutas, D.S., Zaatari, G.S., Santoianni, R.A. J. Lipid Res. (1987) [Pubmed]
  16. Evidence for enhanced vascular superoxide anion production in nitrate tolerance. A novel mechanism underlying tolerance and cross-tolerance. Münzel, T., Sayegh, H., Freeman, B.A., Tarpey, M.M., Harrison, D.G. J. Clin. Invest. (1995) [Pubmed]
  17. Defective RhoA/Rho-kinase signaling contributes to vascular hypocontractility and vasodilation in cirrhotic rats. Hennenberg, M., Biecker, E., Trebicka, J., Jochem, K., Zhou, Q., Schmidt, M., Jakobs, K.H., Sauerbruch, T., Heller, J. Gastroenterology (2006) [Pubmed]
  18. Reflex vasodilation induced by coronary angiography in human subjects. Zelis, R., Caudill, C.C., Baggette, K., Mason, D.T. Circulation (1976) [Pubmed]
  19. Role of the peripheral vasculature in changes in venous return caused by isoproterenol, norepinephrine, and methoxamine in anesthetized dogs. Imai, Y., Satoh, K., Taira, N. Circ. Res. (1978) [Pubmed]
  20. Expression of interleukin-15 in mouse and human atherosclerotic lesions. Wuttge, D.M., Eriksson, P., Sirsjö, A., Hansson, G.K., Stemme, S. Am. J. Pathol. (2001) [Pubmed]
  21. Endothelium-dependent inhibition of Na(+)-K+ ATPase activity in rabbit aorta by hyperglycemia. Possible role of endothelium-derived nitric oxide. Gupta, S., Sussman, I., McArthur, C.S., Tornheim, K., Cohen, R.A., Ruderman, N.B. J. Clin. Invest. (1992) [Pubmed]
  22. The discoidin domain receptor tyrosine kinase DDR1 in arterial wound repair. Hou, G., Vogel, W., Bendeck, M.P. J. Clin. Invest. (2001) [Pubmed]
  23. Aortic endothelial cells regulate proliferation of human monocytes in vitro via a mechanism synergistic with macrophage colony-stimulating factor. Convergence at the cyclin E/p27(Kip1) regulatory checkpoint. Antonov, A.S., Munn, D.H., Kolodgie, F.D., Virmani, R., Gerrity, R.G. J. Clin. Invest. (1997) [Pubmed]
  24. Expression of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein and scavenger receptor in human atherosclerotic lesions. Luoma, J., Hiltunen, T., Särkioja, T., Moestrup, S.K., Gliemann, J., Kodama, T., Nikkari, T., Ylä-Herttuala, S. J. Clin. Invest. (1994) [Pubmed]
  25. Immunohistochemical detection of imidazolone, a novel advanced glycation end product, in kidneys and aortas of diabetic patients. Niwa, T., Katsuzaki, T., Miyazaki, S., Miyazaki, T., Ishizaki, Y., Hayase, F., Tatemichi, N., Takei, Y. J. Clin. Invest. (1997) [Pubmed]
  26. Increased ferritin gene expression in atherosclerotic lesions. Pang, J.H., Jiang, M.J., Chen, Y.L., Wang, F.W., Wang, D.L., Chu, S.H., Chau, L.Y. J. Clin. Invest. (1996) [Pubmed]
  27. Effect of age on kinetics of nitric oxide release in rat aorta and pulmonary artery. Tschudi, M.R., Barton, M., Bersinger, N.A., Moreau, P., Cosentino, F., Noll, G., Malinski, T., Lüscher, T.F. J. Clin. Invest. (1996) [Pubmed]
  28. Activation of heat shock protein (hsp)70 and proto-oncogene expression by alpha1 adrenergic agonist in rat aorta with age. Chin, J.H., Okazaki, M., Hu, Z.W., Miller, J.W., Hoffman, B.B. J. Clin. Invest. (1996) [Pubmed]
  29. Recovery of prostacyclin production by de-endothelialized rabbit aorta. Critical role of neointimal smooth muscle cells. Eldor, A., Falcone, D.J., Hajjar, D.P., Minick, C.R., Weksler, B.B. J. Clin. Invest. (1981) [Pubmed]
  30. Hypotension and reduced nitric oxide-elicited vasorelaxation in transgenic mice overexpressing endothelial nitric oxide synthase. Ohashi, Y., Kawashima, S., Hirata, K., Yamashita, T., Ishida, T., Inoue, N., Sakoda, T., Kurihara, H., Yazaki, Y., Yokoyama, M. J. Clin. Invest. (1998) [Pubmed]
  31. Calmodulin-stimulated cyclic nucleotide phosphodiesterase (PDE1C) is induced in human arterial smooth muscle cells of the synthetic, proliferative phenotype. Rybalkin, S.D., Bornfeldt, K.E., Sonnenburg, W.K., Rybalkina, I.G., Kwak, K.S., Hanson, K., Krebs, E.G., Beavo, J.A. J. Clin. Invest. (1997) [Pubmed]
  32. Evidence for altered balance between matrix metalloproteinases and their inhibitors in human aortic diseases. Knox, J.B., Sukhova, G.K., Whittemore, A.D., Libby, P. Circulation (1997) [Pubmed]
  33. Expression of constitutive and inducible nitric oxide synthases in the vascular wall of young and aging rats. Cernadas, M.R., Sánchez de Miguel, L., García-Durán, M., González-Fernández, F., Millás, I., Montón, M., Rodrigo, J., Rico, L., Fernández, P., de Frutos, T., Rodríguez-Feo, J.A., Guerra, J., Caramelo, C., Casado, S., López-Farré, n.u.l.l. Circ. Res. (1998) [Pubmed]
  34. Patterns of vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 expression in rabbit and mouse atherosclerotic lesions and at sites predisposed to lesion formation. Iiyama, K., Hajra, L., Iiyama, M., Li, H., DiChiara, M., Medoff, B.D., Cybulsky, M.I. Circ. Res. (1999) [Pubmed]
  35. Selective interleukin-12 synthesis defect in 12/15-lipoxygenase-deficient macrophages associated with reduced atherosclerosis in a mouse model of familial hypercholesterolemia. Zhao, L., Cuff, C.A., Moss, E., Wille, U., Cyrus, T., Klein, E.A., Praticò, D., Rader, D.J., Hunter, C.A., Puré, E., Funk, C.D. J. Biol. Chem. (2002) [Pubmed]
  36. Estrogen effects on insulin-like growth factor-I (IGF-I)-induced cell proliferation and IGF-I expression in native and allograft vessels. Lou, H., Zhao, Y., Delafontaine, P., Kodama, T., Katz, N., Ramwell, P.W., Foegh, M.L. Circulation (1997) [Pubmed]
  37. Effect of calcification on in vivo mechanical response of rabbit arteries to balloon dilation. Demer, L.L. Circulation (1991) [Pubmed]
  38. Size matters: the relationship between MMP-9 expression and aortic diameter. McMillan, W.D., Tamarina, N.A., Cipollone, M., Johnson, D.A., Parker, M.A., Pearce, W.H. Circulation (1997) [Pubmed]
  39. Vascular endothelin-1 gene expression and effect on blood pressure of chronic ETA endothelin receptor antagonism after nitric oxide synthase inhibition with L-NAME in normal rats. Sventek, P., Turgeon, A., Schiffrin, E.L. Circulation (1997) [Pubmed]
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