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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Endothelium, Vascular

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Disease relevance of Endothelium, Vascular

  • We have previously demonstrated that significant leukocyte-endothelium interactions occur very early in other forms of ischemia/reperfusion (i.e., splanchnic ischemia/reperfusion and traumatic shock) which are largely mediated by increased expression of the adhesion molecule, P-selectin, on the vascular endothelium [1].
  • We demonstrate that multidrug resistance transporter (Mdr)-1 is upregulated on capillary endothelium after focal cerebral ischemia; moreover, Mdr-1 deactivation by pharmacological inhibition or genetic knockout preferably enhances the accumulation and efficacy of two neuroprotectants known as Mdr-1 substrates in the ischemic brain [2].
  • Transgenic sickle mice expressing betaS hemoglobin have activated vascular endothelium that exhibits enhanced expression of NF-kappaB and adhesion molecules that promote vascular stasis in sickle, but not in normal, mice in response to hypoxia/reoxygenation [3].
  • These studies demonstrate successful expression and delivery of a lipolytic enzyme to the vascular endothelium for ultimate correction of the HL gene defect in HL-deficient mice and indicate that recombinant adenovirus vectors may be useful in the replacement of endothelial-bound lipolytic enzymes in human lipolytic deficiency states [4].
  • In animals sensitive to antigen, a single inhalation exposure induced the rapid expression of ELAM-1 (6 h) exclusively on vascular endothelium that correlated with the influx of neutrophils into the lungs and the onset of late-phase airway obstruction [5].

High impact information on Endothelium, Vascular


Chemical compound and disease context of Endothelium, Vascular


Biological context of Endothelium, Vascular


Anatomical context of Endothelium, Vascular


Associations of Endothelium, Vascular with chemical compounds


Gene context of Endothelium, Vascular


Analytical, diagnostic and therapeutic context of Endothelium, Vascular


  1. Essential role of P-selectin in the initiation of the inflammatory response induced by hemorrhage and reinfusion. Scalia, R., Armstead, V.E., Minchenko, A.G., Lefer, A.M. J. Exp. Med. (1999) [Pubmed]
  2. Inhibition of multidrug resistance transporter-1 facilitates neuroprotective therapies after focal cerebral ischemia. Spudich, A., Kilic, E., Xing, H., Kilic, U., Rentsch, K.M., Wunderli-Allenspach, H., Bassetti, C.L., Hermann, D.M. Nat. Neurosci. (2006) [Pubmed]
  3. Heme oxygenase-1 is a modulator of inflammation and vaso-occlusion in transgenic sickle mice. Belcher, J.D., Mahaseth, H., Welch, T.E., Otterbein, L.E., Hebbel, R.P., Vercellotti, G.M. J. Clin. Invest. (2006) [Pubmed]
  4. Hepatic lipase gene therapy in hepatic lipase-deficient mice. Adenovirus-mediated replacement of a lipolytic enzyme to the vascular endothelium. Applebaum-Bowden, D., Kobayashi, J., Kashyap, V.S., Brown, D.R., Berard, A., Meyn, S., Parrott, C., Maeda, N., Shamburek, R., Brewer, H.B., Santamarina-Fojo, S. J. Clin. Invest. (1996) [Pubmed]
  5. Endothelial leukocyte adhesion molecule-1 mediates antigen-induced acute airway inflammation and late-phase airway obstruction in monkeys. Gundel, R.H., Wegner, C.D., Torcellini, C.A., Clarke, C.C., Haynes, N., Rothlein, R., Smith, C.W., Letts, L.G. J. Clin. Invest. (1991) [Pubmed]
  6. Selectin-carbohydrate interactions and the initiation of the inflammatory response. Lasky, L.A. Annu. Rev. Biochem. (1995) [Pubmed]
  7. Mutations in Sox18 underlie cardiovascular and hair follicle defects in ragged mice. Pennisi, D., Gardner, J., Chambers, D., Hosking, B., Peters, J., Muscat, G., Abbott, C., Koopman, P. Nat. Genet. (2000) [Pubmed]
  8. Suppression of thromboxane A2 but not of systemic prostacyclin by controlled-release aspirin. Clarke, R.J., Mayo, G., Price, P., FitzGerald, G.A. N. Engl. J. Med. (1991) [Pubmed]
  9. ELAM-1--dependent cell adhesion to vascular endothelium determined by a transfected human fucosyltransferase cDNA. Lowe, J.B., Stoolman, L.M., Nair, R.P., Larsen, R.D., Berhend, T.L., Marks, R.M. Cell (1990) [Pubmed]
  10. Endothelial cell tumors develop in transgenic mice carrying polyoma virus middle T oncogene. Bautch, V.L., Toda, S., Hassell, J.A., Hanahan, D. Cell (1987) [Pubmed]
  11. Human immunodeficiency virus-1 (HIV-1)-Tat protein promotes migration of acquired immunodeficiency syndrome-related lymphoma cells and enhances their adhesion to endothelial cells. Chirivi, R.G., Taraboletti, G., Bani, M.R., Barra, L., Piccinini, G., Giacca, M., Bussolino, F., Giavazzi, R. Blood (1999) [Pubmed]
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  13. Down-regulation of glutathione and Bcl-2 synthesis in mouse B16 melanoma cells avoids their survival during interaction with the vascular endothelium. Ortega, A., Ferrer, P., Carretero, J., Obrador, E., Asensi, M., Pellicer, J.A., Estrela, J.M. J. Biol. Chem. (2003) [Pubmed]
  14. Direct vascular and cardioprotective effects of rosuvastatin, a new HMG-CoA reductase inhibitor. Jones, S.P., Gibson, M.F., Rimmer, D.M., Gibson, T.M., Sharp, B.R., Lefer, D.J. J. Am. Coll. Cardiol. (2002) [Pubmed]
  15. Effects of continuous infusion of endothelin-1 in pregnant sheep. Greenberg, S.G., Baker, R.S., Yang, D., Clark, K.E. Hypertension (1997) [Pubmed]
  16. Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium. Topper, J.N., Cai, J., Qiu, Y., Anderson, K.R., Xu, Y.Y., Deeds, J.D., Feeley, R., Gimeno, C.J., Woolf, E.A., Tayber, O., Mays, G.G., Sampson, B.A., Schoen, F.J., Gimbrone, M.A., Falb, D. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  17. Vascular cell adhesion molecule-1 is induced on vascular endothelia and medial smooth muscle cells in experimental cardiac allograft vasculopathy. Ardehali, A., Laks, H., Drinkwater, D.C., Ziv, E., Drake, T.A. Circulation (1995) [Pubmed]
  18. Regulation of endothelin 1 gene by fluid shear stress is transcriptionally mediated and independent of protein kinase C and cAMP. Malek, A.M., Greene, A.L., Izumo, S. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  19. Inhibition of nuclear factor-kappa B nuclear localization reduces human E-selectin expression and the systemic inflammatory response. Boyle, E.M., Kovacich, J.C., Canty, T.G., Morgan, E.N., Chi, E., Verrier, E.D., Pohlman, T.H. Circulation (1998) [Pubmed]
  20. Cell swelling, heat, and chemical agonists use distinct pathways for the activation of the cation channel TRPV4. Vriens, J., Watanabe, H., Janssens, A., Droogmans, G., Voets, T., Nilius, B. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  21. MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Gerszten, R.E., Garcia-Zepeda, E.A., Lim, Y.C., Yoshida, M., Ding, H.A., Gimbrone, M.A., Luster, A.D., Luscinskas, F.W., Rosenzweig, A. Nature (1999) [Pubmed]
  22. Angiotensin-converting enzyme: vascular endothelial localization. Caldwell, P.R., Seegal, B.C., Hsu, K.C., Das, M., Soffer, R.L. Science (1976) [Pubmed]
  23. Chemokines trigger immediate beta2 integrin affinity and mobility changes: differential regulation and roles in lymphocyte arrest under flow. Constantin, G., Majeed, M., Giagulli, C., Piccio, L., Kim, J.Y., Butcher, E.C., Laudanna, C. Immunity (2000) [Pubmed]
  24. P-Selectin glycoprotein ligand 1 (PSGL-1) is a physiological ligand for E-selectin in mediating T helper 1 lymphocyte migration. Hirata, T., Merrill-Skoloff, G., Aab, M., Yang, J., Furie, B.C., Furie, B. J. Exp. Med. (2000) [Pubmed]
  25. Induction and detection of a human endothelial activation antigen in vivo. Cotran, R.S., Gimbrone, M.A., Bevilacqua, M.P., Mendrick, D.L., Pober, J.S. J. Exp. Med. (1986) [Pubmed]
  26. Increased prostacyclin biosynthesis in patients with severe atherosclerosis and platelet activation. FitzGerald, G.A., Smith, B., Pedersen, A.K., Brash, A.R. N. Engl. J. Med. (1984) [Pubmed]
  27. No evidence for expression of the insulin-regulatable glucose transporter in endothelial cells. Slot, J.W., Moxley, R., Geuze, H.J., James, D.E. Nature (1990) [Pubmed]
  28. Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor. Gryglewski, R.J., Palmer, R.M., Moncada, S. Nature (1986) [Pubmed]
  29. Aspirin causes short-lived inhibition of bradykinin-stimulated prostacyclin production in man. Heavey, D.J., Barrow, S.E., Hickling, N.E., Ritter, J.M. Nature (1985) [Pubmed]
  30. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Fong, G.H., Rossant, J., Gertsenstein, M., Breitman, M.L. Nature (1995) [Pubmed]
  31. Dll4, a novel Notch ligand expressed in arterial endothelium. Shutter, J.R., Scully, S., Fan, W., Richards, W.G., Kitajewski, J., Deblandre, G.A., Kintner, C.R., Stark, K.L. Genes Dev. (2000) [Pubmed]
  32. Interferon gamma regulates platelet endothelial cell adhesion molecule 1 expression and neutrophil infiltration into herpes simplex virus-infected mouse corneas. Tang, Q., Hendricks, R.L. J. Exp. Med. (1996) [Pubmed]
  33. Vascular endothelium is critically involved in the hypotensive and hypovolemic actions of atrial natriuretic peptide. Sabrane, K., Kruse, M.N., Fabritz, L., Zetsche, B., Mitko, D., Skryabin, B.V., Zwiener, M., Baba, H.A., Yanagisawa, M., Kuhn, M. J. Clin. Invest. (2005) [Pubmed]
  34. Regulation of endothelial nitric oxide synthase: location, location, location. Shaul, P.W. Annu. Rev. Physiol. (2002) [Pubmed]
  35. Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium. Quinn, T.P., Peters, K.G., De Vries, C., Ferrara, N., Williams, L.T. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  36. Detection of protein C activation in humans. Bauer, K.A., Kass, B.L., Beeler, D.L., Rosenberg, R.D. J. Clin. Invest. (1984) [Pubmed]
  37. Interactions of leukocyte integrins with intercellular adhesion molecule 1 in the production of inflammatory vascular injury in vivo. The Shwartzman reaction revisited. Argenbright, L.W., Barton, R.W. J. Clin. Invest. (1992) [Pubmed]
  38. Histamine receptors of the microvascular endothelium revealed in situ with a histamine-ferritin conjugate: characteristic high-affinity binding sites in venules. Heltianu, C., Simionescu, M., Simionescu, N. J. Cell Biol. (1982) [Pubmed]
  39. Mouse Polycomb M33 is required for splenic vascular and adrenal gland formation through regulating Ad4BP/SF1 expression. Katoh-Fukui, Y., Owaki, A., Toyama, Y., Kusaka, M., Shinohara, Y., Maekawa, M., Toshimori, K., Morohashi, K. Blood (2005) [Pubmed]
  40. Expression of B-cell-attracting chemokine 1 (CXCL13) by malignant lymphocytes and vascular endothelium in primary central nervous system lymphoma. Smith, J.R., Braziel, R.M., Paoletti, S., Lipp, M., Uguccioni, M., Rosenbaum, J.T. Blood (2003) [Pubmed]
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