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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Monocyte Differentiation toward Regulatory Dendritic Cells Is Not Affected by Respiratory Syncytial Virus-Induced Inflammatory Mediators.

Airway epithelial cells were shown to drive the differentiation of monocytes into dendritic cells (DCs) with a suppressive phenotype. In this study, we investigated the impact of virus-induced inflammatory mediator production on the development of DCs. Monocyte differentiation into functional DCs, as reflected by the expression of CD11c, CD123, BDCA-4, and DC-SIGN and the capacity to activate T cells, was similar for respiratory syncytial virus (RSV)-infected and mock-infected BEAS-2B and A549 cells. RSV-conditioned culture media resulted in a partially mature DC phenotype, but failed to up-regulate CD80, CD83, CD86, and CCR7, and failed to release proinflammatory mediators upon Toll-like receptor (TLR) triggering. Nevertheless, these DCs were able to maintain an antiviral response by the release of Type I IFN. Collectively, these data indicate that the airway epithelium maintains an important suppressive DC phenotype under the inflammatory conditions induced by infection with RSV.[1]

References

  1. Monocyte Differentiation toward Regulatory Dendritic Cells Is Not Affected by Respiratory Syncytial Virus-Induced Inflammatory Mediators. Sluijs, K.F., Obregon, C., Geiser, T.K., Mühlemann, K., Nicod, L.P. Am. J. Respir. Cell Mol. Biol. (2011) [Pubmed]
 
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