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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Central giant-cell granulomas are benign, but occasionally aggressive, lesions that traditionally have been treated surgically.21 cases of central giant-cell granuloma of the jaw were treated with intralesional injection of corticosteroids.The treatment protocol adopted was intralesional injection of 20mg/ml triamcinolone hexacetonide diluted in an anaesthetic solution of 2% lidocaine/epinephrine 1:200,000 in the proportion 1:1; 1.0ml of the solution was infiltrated for every 1cm(3) of radiolucid area of the lesion, totalling 6 biweekly applications.Ten patients had aggressive lesions and 11 nonaggressive.Two patients showed a negative response to the treatment and underwent surgical resection, 4 showed a moderate response and 15 a good response.8 of the 19 who had a moderate-to-good response to the drug treatment underwent osteoplasty to reestablish facial aesthetics.In these cases, only mature or dysplastic bone was observed, with the presence or absence of rare giant multinucleated cells.The advantages of this therapy are its less-invasive nature, the probable lower cost to the patient, lower risk and the ability to treat the lesion surgically in the future, if necessary.[1]
