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Chemical Compound Review

Aristocort     (8S,9S,10S,11S,13S,14S,16R,17R )-9-fluoro...

Synonyms: Adcortyl, Cinolone, Kenacort, Omicilon, Triaderm, ...
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Disease relevance of Kenalog

  • Long-term Retinal Toxicity of Intravitreal Commercially Available Preserved Triamcinolone Acetonide (Kenalog) in Rabbit Eyes [1].
  • OBJECTIVE: To determine the safety and efficacy of subconjunctival triamcinolone (Kenalog) in treating nonnecrotizing anterior scleritis [2].
  • OBJECTIVE: Prospective assessment of the efficacy and tolerability of intra-articular sodium hyaluronate (SH; Ostenil mini) and triamcinolone acetonide (TA; Volon A10) for treatment of osteoarthritis (OA) of the carpometacarpal (CMC) joint of the thumb in a 26-week, controlled, randomized, on an intention to treat, masked-observer study [3].
  • Histomorphologic changes in keloids treated with Kenacort [4].
  • We have never known Kenalog to fail to improve a hypertrophic scar by flattening it out to a significant extent, but it may take a year or more of injections to accomplish this goal [5].

High impact information on Kenalog


Chemical compound and disease context of Kenalog


Biological context of Kenalog

  • The seasonal incidence and diel oviposition patterns of sylvan Haemagogus celeste and Hg. leucocelaenus in the Pt [15].
  • At two-week follow-up, the prednisone group showed a median improvement in Snellen visual acuity of +2.0 lines, while the triamcinalone group remained essentially stable with a 0.5 line median loss [16].

Anatomical context of Kenalog


Associations of Kenalog with other chemical compounds


Gene context of Kenalog

  • The sequence of the rat BGP gene was compared to that of the recently published human BGP gene (Celeste et al., EMBO J. 5, 1885, 1986) [22].
  • This study uses spectrum analysis to examine a large number of recordings of a particularly challenging high note for tenors, the final sustained B4-flat of the aria 'Celeste Aida' from Verdi's opera Aida [23].
  • Skin irritation was reduced by both corticosteroid sprays, with the fraction of subjects who experienced moderate irritation reduced by 57% and 43% for the Kenalog and Cortizone-10 Quick Shot sprays, respectively [24].
  • Administration of Kenalog (2 mg/kg), a pharmacological analog of glucocorticoid hormones, prevented the poststress activation of MAO-B and LPO and decreased the extent of anxiogenic behavioral abnormalities in rats [25].

Analytical, diagnostic and therapeutic context of Kenalog


  1. Long-term Retinal Toxicity of Intravitreal Commercially Available Preserved Triamcinolone Acetonide (Kenalog) in Rabbit Eyes. Albini, T.A., Abd-El-Barr, M.M., Carvounis, P.E., Iyer, M.N., Lakhanpal, R.R., Pennesi, M.E., Chevez-Barrios, P., Wu, S.M., Holz, E.R. Invest. Ophthalmol. Vis. Sci. (2007) [Pubmed]
  2. Therapy of nonnecrotizing anterior scleritis with subconjunctival corticosteroid injection. Tu, E.Y., Culbertson, W.W., Pflugfelder, S.C., Huang, A., Chodosh, J.C. Ophthalmology (1995) [Pubmed]
  3. Intra-articular hyaluronic acid compared with corticoid injections for the treatment of rhizarthrosis. Fuchs, S., Mönikes, R., Wohlmeiner, A., Heyse, T. Osteoarthr. Cartil. (2006) [Pubmed]
  4. Histomorphologic changes in keloids treated with Kenacort. Boyadjiev, C., Popchristova, E., Mazgalova, J. The Journal of trauma. (1995) [Pubmed]
  5. Secondary burn reconstruction: recent advances with microvascular free flaps, regional flaps, and specialized grafts. Stallings, J.O., Ban, J.L., Pandeya, N.K., Abramsohn, L., Bergman, R.S. The American surgeon. (1982) [Pubmed]
  6. Effects of cytotoxic T lymphocyte antigen 4 (CTLA4) signaling and locally applied steroid on retinal dysfunction by recoverin, cancer-associated retinopathy antigen. Maeda, A., Maeda, T., Liang, Y., Yenerel, M., Saperstein, D.A. Mol. Vis. (2006) [Pubmed]
  7. Visualizing vitreous using Kenalog suspension. Burk, S.E., Da Mata, A.P., Snyder, M.E., Schneider, S., Osher, R.H., Cionni, R.J. Journal of cataract and refractive surgery. (2003) [Pubmed]
  8. A quantitative evaluation of suture and tubulization nerve repair techniques. Gibby, W.A., Koerber, H.R., Horch, K.W. J. Neurosurg. (1983) [Pubmed]
  9. Short-term Intraocular Pressure Trends After Intravitreal Triamcinolone Injection. Lee, E.W., Hariprasad, S.M., Mieler, W.F., Newman, T.L., Apte, R.S. Am. J. Ophthalmol. (2007) [Pubmed]
  10. Bleomycin tattooing as a promising therapeutic modality in large keloids and hypertrophic scars. Naeini, F.F., Najafian, J., Ahmadpour, K. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. (2006) [Pubmed]
  11. Efficacy of epidural injections of Kenalog and Celestone in the treatment of lower back pain. Stanczak, J., Blankenbaker, D.G., De Smet, A.A., Fine, J. AJR. American journal of roentgenology. (2003) [Pubmed]
  12. Experimental and clinical observations of the intraocular toxicity of commercial corticosteroid preparations. Hida, T., Chandler, D., Arena, J.E., Machemer, R. Am. J. Ophthalmol. (1986) [Pubmed]
  13. Intra-articular steroids in osteoarthritis. Dieppe, P.A., Sathapatayavongs, B., Jones, H.E., Bacon, P.A., Ring, E.F. Rheumatology and rehabilitation. (1980) [Pubmed]
  14. Intralesional corticosteroids as an alternative treatment for central giant cell granuloma. Carlos, R., Sedano, H.O. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. (2002) [Pubmed]
  15. Seasonal incidence and diel oviposition periodicity of Haemagogus mosquitoes (Diptera: Culicidae) in Trinidad, W.I. Part III. Haemagogus celeste (Dyar and Nunez Tovar) and Haemagogus leucocelaenus (Dyar and Shannon). Chadee, D.D., Tikasingh, E.S. Ann. Trop. Med. Parasitol. (1991) [Pubmed]
  16. Corticosteroids as an antiangiogenic agent for histoplasmosis-related subfoveal choroidal neovascularization. Martidis, A., Miller, D.G., Ciulla, T.A., Danis, R.P., Moorthy, R.S. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. (1999) [Pubmed]
  17. Drug effects on arthrosis. Comparison in rabbits of 3 modes of action. Olijhoek, G., Drukker, J., van der Linden, T.J., Terwindt-Rouwenhorst, E.A. Acta orthopaedica Scandinavica. (1988) [Pubmed]
  18. Finger tendon rupture following local application of triamcinolone-acetonide (Kenalog A-40). Jakubík, J. Acta chirurgiae plasticae. (1981) [Pubmed]
  19. Cyanoacrylate as an adhesive for other medicaments: a study with triamcinalone on the healing of experimental oral ulcers. Sonis, S., Jandinski, J.J., Qiunta, J. Pharmacology and therapeutics in dentistry. (1975) [Pubmed]
  20. Corticosteroid injections of the nasal turbinates: past experience and precautions. McCleve, D., Goldstein, J., Silver, S. Otolaryngology. (1978) [Pubmed]
  21. Triamcinolone acetonide protects auditory hair cells from 4-hydroxy-2,3-nonenal (HNE) ototoxicity in vitro. Guzman, J., Ruiz, J., Eshraghi, A.A., Polak, M., Garnham, C., Balkany, T.J., Van de Water, T.R. Acta Otolaryngol. (2006) [Pubmed]
  22. Molecular structure of the rat bone Gla protein gene and identification of putative regulatory elements. Theofan, G., Haberstroh, L.M., Price, P.A. DNA (1989) [Pubmed]
  23. Resonance strategies revealed in recorded tenor high notes. Schutte, H.K., Miller, D.G., Duijnstee, M. Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP). (2005) [Pubmed]
  24. The effect of preapplication of corticosteroids on skin irritation and performance of the GlucoWatch G2 Biographer. Tamada, J.A., Davis, T.L., Leptien, A.D., Lee, J., Wang, B., Lopatin, M., Wei, C., Wilson, D., Comyns, K., Eastman, R.C. Diabetes Technol. Ther. (2004) [Pubmed]
  25. Decreases in glucocorticoid sensitivity as a factor of stress-producing changes in the activity of monoamine oxidase, lipid peroxidation, and behavior in rats. Volchegorskii, I.A., Tseilikman, V.E., Smirnov, D.S., Ship, S.A., Borisenkov, A.V. Neurosci. Behav. Physiol. (2004) [Pubmed]
  26. Late-onset granulomatous reaction to Artecoll. Alcalay, J., Alkalay, R., Gat, A., Yorav, S. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. (2003) [Pubmed]
  27. Photographic estimation of the duration of high dose intravitreal triamcinolone in the vitrectomised eye. Kosobucki, B.R., Freeman, W.R., Cheng, L. The British journal of ophthalmology. (2006) [Pubmed]
  28. Acupuncture induced immunoregulatory influence on the clinical state of patients suffering from chronic spastic bronchitis and undergoing long-term treatment with corticosteroids. Sliwinski, J., Kulej, M. Acupuncture & electro-therapeutics research. (1989) [Pubmed]
  29. Safety and pharmacokinetics of a preservative-free triamcinolone acetonide formulation for intravitreal administration. Kim, H., Csaky, K.G., Gravlin, L., Yuan, P., Lutz, R.J., Bungay, P.M., Tansey, G., DE Monasterio, F., Potti, G.K., Grimes, G., Robinson, M.R. Retina (Philadelphia, Pa.) (2006) [Pubmed]
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