Disease relevance of Kenalog

• Long-term Retinal Toxicity of Intravitreal Commercially Available Preserved Triamcinolone Acetonide (Kenalog) in Rabbit Eyes [1].
• OBJECTIVE: To determine the safety and efficacy of subconjunctival triamcinolone (Kenalog) in treating nonnecrotizing anterior scleritis [2].
• OBJECTIVE: Prospective assessment of the efficacy and tolerability of intra-articular sodium hyaluronate (SH; Ostenil mini) and triamcinolone acetonide (TA; Volon A10) for treatment of osteoarthritis (OA) of the carpometacarpal (CMC) joint of the thumb in a 26-week, controlled, randomized, on an intention to treat, masked-observer study [3].
• Histomorphologic changes in keloids treated with Kenacort [4].
• We have never known Kenalog to fail to improve a hypertrophic scar by flattening it out to a significant extent, but it may take a year or more of injections to accomplish this goal [5].

High impact information on Kenalog

• PURPOSE: To assess the cytotoxic T lymphocyte antigen 4 (CTLA4) pathway in the recoverin peptide (R64; AYAQHVFRSF) mouse model of cancer-associated retinopathy (CAR) and to assess the protective effects of subconjunctival triamcinalone injections in this model [6].
• In this study, 0.2 mL of injectable triamcinolone (Kenalog) 40 mg/mL was captured in a 5 microm filter and rinsed with 2 mL of balanced salt solution (BSS) [7].
• The Kenalog particles were ultimately resuspended in 2 mL of BSS and injected into the anterior chamber through a 27-gauge cannula [7].
• The radial and sural nerves in cats were transected and either left unrepaired, repaired with 11-0 epineurial sutures, sutured and treated with topical application of Kenalog, or tubulated with hypoantigenic collagen [8].
• PURPOSE: To report the trends in intraocular pressures (IOP) within the first week after intravitreal injection of triamcinolone acetonide (Kenalog) for the treatment of retinal disease [9].

Chemical compound and disease context of Kenalog

• OBJECTIVE: This study compares the efficacy of bleomycin tattoo with that of cryotherapy combined with intralesional triamcinolon injection for the treatment of keloids and hypertrophic scars [10].
• MATERIALS AND METHODS: We reviewed charts and self-reported pain score evaluations of 597 patients who received either Kenalog or Celestone Soluspan as an epidural injection for the treatment of lower back pain from 1997 to 2002 at our university hospital and affiliated Veterans Affairs hospital [11].
• We tested the vehicles of six different commercially available depot corticosteroids (Celestone Soluspan, Depo-Medrol, Decadron, Decadron L. A., Aristocort, and Kenalog) for possible toxicity when injected intravitreally [12].
• Intra-articular steroid therapy for osteoarthritis of the knee has been reassessed by two placebo-controlled trials of 20 mg of triamcinalone hexacetonide in 48 joints [13].
• Four cases of central giant cell granuloma were treated with intralesional infiltration of a solution of Kenacort-A (10 mg/mL, triamcinolone aqueous suspension SQUIBB) and either (1) Lidocaine 2% with epinephrine 1:200,000 Marcaine or (2) Bupivacaine, 50% mixture by volume [14].

Biological context of Kenalog

• The seasonal incidence and diel oviposition patterns of sylvan Haemagogus celeste and Hg. leucocelaenus in the Pt [15].
• At two-week follow-up, the prednisone group showed a median improvement in Snellen visual acuity of +2.0 lines, while the triamcinalone group remained essentially stable with a 0.5 line median loss [16].

Anatomical context of Kenalog

• Arteparon, Trasylol, and Kenacort A10 increased the contents of acidic glycosaminoglycans in the chondrocytes [17].
• Attention was directed to the characterization of the tree states of fibroblasts in keloids treated with Kenacort [4].
• Finger tendon rupture following local application of triamcinolone-acetonide (Kenalog A-40) [18].
• Triamcinalone was chosen since it is used presently in pastes in the oral cavity [19].
• Clinical experience with triamcinolone acetonide (Kenalog) injections into the nasal turbinates for allergic and vasomotor rhinitis is reported by two authors [20].

Associations of Kenalog with other chemical compounds

• RESULTS: Therapeutic response in lesions less than 100 mm2 was higher than 88% in both groups, but in larger lesions, the therapeutic response to bleomycin was significantly better than cryotherapy combined with intralesional triamcinolon injection (p = .03) [10].
• CONCLUSION: The epidural injection of Celestone Soluspan and Kenalog reduced lower back and radicular pain in more than half the patients, although Kenalog reduced pain in a significantly larger number of patients than Celestone Soluspan at 1 and 2 weeks after injection [11].
• CONCLUSION: Triamcinolone acetonide crystalline suspension (e.g. Volon A) was not ototoxic to the auditory hair cells present within organ of Corti explants and protected them from an ototoxic molecule, i.e. 4-hydroxy-2,3-nonenal (HNE), that is produced within the organ of Corti as a result of oxidative stress-induced damage [21].

Gene context of Kenalog

• The sequence of the rat BGP gene was compared to that of the recently published human BGP gene (Celeste et al., EMBO J. 5, 1885, 1986) [22].
• This study uses spectrum analysis to examine a large number of recordings of a particularly challenging high note for tenors, the final sustained B4-flat of the aria 'Celeste Aida' from Verdi's opera Aida [23].
• Skin irritation was reduced by both corticosteroid sprays, with the fraction of subjects who experienced moderate irritation reduced by 57% and 43% for the Kenalog and Cortizone-10 Quick Shot sprays, respectively [24].
• Administration of Kenalog (2 mg/kg), a pharmacological analog of glucocorticoid hormones, prevented the poststress activation of MAO-B and LPO and decreased the extent of anxiogenic behavioral abnormalities in rats [25].

Analytical, diagnostic and therapeutic context of Kenalog

• Group A was treated with bleomycin tattoo, and group B, with cryotherapy combined with intralesional triamcinolon injection [10].
• Intralesional injections of Kenalog caused temporary disappearance of the granulomas [26].
• METHODS: 23 eyes of 23 patients underwent intravitreal injection of high dose (20 mg) decanted triamcinolone acetonide (Kenalog) at the conclusion of vitrectomy surgery or in previously vitrectomised eyes with macular oedema from diabetes, uveitis, cataract surgery, or other surgery [27].
• The patients took intramuscular injections of 40 to 60 mg Kenalog (Squibb) every three or four weeks [28].
• TA-PF (4-mg and 16-mg doses) and Kenalog (Bristol-Myers-Squibb, Princeton, NJ) (4-mg dose) were injected into the vitreous of separate groups of rabbits, and drug levels were measured in the vitreous over time with HPLC [29].

References