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MeSH Review

Clinical Protocols

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Disease relevance of Clinical Protocols


Psychiatry related information on Clinical Protocols


High impact information on Clinical Protocols

  • A treatment protocol was introduced in 1979 for patients admitted to Johns Hopkins Hospital with the diagnosis of TTP-HUS [11].
  • We successfully induced immune tolerance in patients with such antibodies with a new treatment protocol, which combined factor VIII, cyclophosphamide, and high-dose intravenous IgG, followed by regular prophylactic treatment with factor VIII [12].
  • It is clear that the monitoring of parameters other than linear growth to help refine GH therapy should now be incorporated into childhood GH treatment protocols [13].
  • A treatment protocol of four doses of 800 nanograms of TGF-beta resulted in v-src-expressing tumors with 100% frequency; four doses of only 10 nanograms still led to tumor formation in 80% of the animals [14].
  • Overall, the nonempiric basis for including estramustine in clinical protocols that contain other multidrug-resistant drugs is strengthened by the present data [15].

Chemical compound and disease context of Clinical Protocols


Biological context of Clinical Protocols


Anatomical context of Clinical Protocols


Associations of Clinical Protocols with chemical compounds


Gene context of Clinical Protocols


Analytical, diagnostic and therapeutic context of Clinical Protocols


  1. Correlation of in vitro drug-sensitivity testing results with response to chemotherapy and survival in extensive-stage small cell lung cancer: a prospective clinical trial. Gazdar, A.F., Steinberg, S.M., Russell, E.K., Linnoila, R.I., Oie, H.K., Ghosh, B.C., Cotelingam, J.D., Johnson, B.E., Minna, J.D., Ihde, D.C. J. Natl. Cancer Inst. (1990) [Pubmed]
  2. Prognostic significance of fluorescence intensity of surface marker expression in childhood B-precursor acute lymphoblastic leukemia. A Pediatric Oncology Group Study. Borowitz, M.J., Shuster, J., Carroll, A.J., Nash, M., Look, A.T., Camitta, B., Mahoney, D., Lauer, S.J., Pullen, D.J. Blood (1997) [Pubmed]
  3. Rapid and efficient selection of human hematopoietic cells expressing murine heat-stable antigen as an indicator of retroviral-mediated gene transfer. Conneally, E., Bardy, P., Eaves, C.J., Thomas, T., Chappel, S., Shpall, E.J., Humphries, R.K. Blood (1996) [Pubmed]
  4. Interleukin 2 induction of lymphokine-activated killer (LAK) activity in the peripheral blood and bone marrow of acute leukemia patients. I. Feasibility of LAK generation in adult patients with active disease and in remission. Adler, A., Chervenick, P.A., Whiteside, T.L., Lotzová, E., Herberman, R.B. Blood (1988) [Pubmed]
  5. Oligodeoxyribonucleotide uptake in primary human hematopoietic cells is enhanced by cationic lipids and depends on the hematopoietic cell subset. Kronenwett, R., Steidl, U., Kirsch, M., Sczakiel, G., Haas, R. Blood (1998) [Pubmed]
  6. Nicotine patch therapy for smoking cessation in recovering alcoholics. Hurt, R.D., Dale, L.C., Offord, K.P., Croghan, I.T., Hays, J.T., Gomez-Dahl, L. Addiction (1995) [Pubmed]
  7. Relationship between CD4 count, viral burden, and quality of life over time in HIV-1-infected patients. Weinfurt, K.P., Willke, R.J., Glick, H.A., Freimuth, W.W., Schulman, K.A. Medical care. (2000) [Pubmed]
  8. One-step liquid-liquid extraction of cocaine from urine samples for gas chromatographic analysis. Farina, M., Yonamine, M., Silva, O.A. Forensic Sci. Int. (2002) [Pubmed]
  9. Ethnic differences in HIV risk behaviors, self-perceptions, and treatment outcomes among women in methadone maintenance treatment. Grella, C.E., Annon, J.J., Anglin, M.D. Journal of psychoactive drugs. (1995) [Pubmed]
  10. Do blood pressure and age predict response to tacrine (THA) in Alzheimer's disease? A preliminary report. Schneider, L.S., Lyness, S.A., Pawluczyk, S., Gleason, R.P., Sloane, R.B. Psychopharmacology bulletin. (1991) [Pubmed]
  11. Improved survival in thrombotic thrombocytopenic purpura-hemolytic uremic syndrome. Clinical experience in 108 patients. Bell, W.R., Braine, H.G., Ness, P.M., Kickler, T.S. N. Engl. J. Med. (1991) [Pubmed]
  12. Induction of immune tolerance in patients with hemophilia and antibodies to factor VIII by combined treatment with intravenous IgG, cyclophosphamide, and factor VIII. Nilsson, I.M., Berntorp, E., Zettervall, O. N. Engl. J. Med. (1988) [Pubmed]
  13. Optimizing gh therapy in adults and children. Drake, W.M., Howell, S.J., Monson, J.P., Shalet, S.M. Endocr. Rev. (2001) [Pubmed]
  14. Mediation of wound-related Rous sarcoma virus tumorigenesis by TGF-beta. Sieweke, M.H., Thompson, N.L., Sporn, M.B., Bissell, M.J. Science (1990) [Pubmed]
  15. P-glycoprotein binding and modulation of the multidrug-resistant phenotype by estramustine. Speicher, L.A., Barone, L.R., Chapman, A.E., Hudes, G.R., Laing, N., Smith, C.D., Tew, K.D. J. Natl. Cancer Inst. (1994) [Pubmed]
  16. Down-regulation of intestinal lymphocyte activation and Th1 cytokine production by antibiotic therapy in a murine model of Crohn's disease. Bamias, G., Marini, M., Moskaluk, C.A., Odashima, M., Ross, W.G., Rivera-Nieves, J., Cominelli, F. J. Immunol. (2002) [Pubmed]
  17. Lack of superinfection interference in retroviral vector producer cells. Vogt, B., Roscher, S., Abel, B., Hildinger, M., Lamarre, A., Baum, C., von Laer, D. Hum. Gene Ther. (2001) [Pubmed]
  18. Acquisition of chemoresistance in a human ovarian carcinoma cell is linked to a defect in cell cycle control. Poulain, L., Lincet, H., Duigou, F., Deslandes, E., Sichel, F., Gauduchon, P., Staedel, C. Int. J. Cancer (1998) [Pubmed]
  19. Endocrine perturbation increases susceptibility of mice to anthrax lethal toxin. Moayeri, M., Webster, J.I., Wiggins, J.F., Leppla, S.H., Sternberg, E.M. Infect. Immun. (2005) [Pubmed]
  20. A randomized phase II study on the effects of 5-Aza-2'-deoxycytidine combined with either amsacrine or idarubicin in patients with relapsed acute leukemia: an EORTC Leukemia Cooperative Group phase II study (06893). Willemze, R., Suciu, S., Archimbaud, E., Muus, P., Stryckmans, P., Louwagie, E.A., Berneman, Z., Tjean, M., Wijermans, P., Dohner, H., Jehn, U., Labar, B., Jaksic, B., Dardenne, M., Zittoun, R. Leukemia (1997) [Pubmed]
  21. Molecular genetics of mucopolysaccharidosis type I: diagnostic, clinical, and biological implications. Scott, H.S., Bunge, S., Gal, A., Clarke, L.A., Morris, C.P., Hopwood, J.J. Hum. Mutat. (1995) [Pubmed]
  22. The metabolism, pharmacokinetics and mechanisms of antiviral activity of ribavirin against hepatitis C virus. Dixit, N.M., Perelson, A.S. Cell. Mol. Life Sci. (2006) [Pubmed]
  23. Persistence of cyclophosphamide-induced damage in bone marrow as indicated by sister chromatid exchange analysis. Takeshita, T., Conner, M.K. Carcinogenesis (1985) [Pubmed]
  24. Suppression by delta-9-tetrahydrocannabinol of lipopolysaccharide-induced and intrinsic tyrosine phosphorylation and protein expression in mouse peritoneal macrophages. Zheng, Z.M., Specter, S. Biochem. Pharmacol. (1994) [Pubmed]
  25. Elevated serum progesterone levels during pituitary suppression may signify adrenal hyperandrogenism. Eldar-Geva, T., Margalioth, E.J., Brooks, B., Algur, N., Gal, M., Zylber-Haran, E., Bar, I., Diamant, Y.Z. Fertil. Steril. (1997) [Pubmed]
  26. Avascular necrosis of femoral and/or humeral heads in multiple myeloma: results of a prospective study of patients treated with dexamethasone-based regimens and high-dose chemotherapy. Talamo, G., Angtuaco, E., Walker, R.C., Dong, L., Miceli, M.H., Zangari, M., Tricot, G., Barlogie, B., Anaissie, E. J. Clin. Oncol. (2005) [Pubmed]
  27. Interferon-gamma receptor signaling is dispensable in the development of autoimmune type 1 diabetes in NOD mice. Serreze, D.V., Post, C.M., Chapman, H.D., Johnson, E.A., Lu, B., Rothman, P.B. Diabetes (2000) [Pubmed]
  28. Vascular injury: mechanisms and manifestations. Nayler, W.G. Am. J. Med. (1991) [Pubmed]
  29. Effect of corticosteroids on the expression of cytochromes P450 and on cyclosporin A oxidase activity in primary cultures of human hepatocytes. Pichard, L., Fabre, I., Daujat, M., Domergue, J., Joyeux, H., Maurel, P. Mol. Pharmacol. (1992) [Pubmed]
  30. Prognostic value of cytosolic thymidine kinase activity as a marker of proliferation in breast cancer. Romain, S., Christensen, I.J., Chinot, O., Balslev, I., Rose, C., Martin, P.M., Thorpe, S.M. Int. J. Cancer (1995) [Pubmed]
  31. ERCC1 and ERCC2 expression in malignant tissues from ovarian cancer patients. Dabholkar, M., Bostick-Bruton, F., Weber, C., Bohr, V.A., Egwuagu, C., Reed, E. J. Natl. Cancer Inst. (1992) [Pubmed]
  32. Delayed androgen treatment prolongs survival in murine lupus. Roubinian, J.R., Talal, N., Greenspan, J.S., Goodman, J.R., Siiteri, P.K. J. Clin. Invest. (1979) [Pubmed]
  33. Methotrexate systemic clearance influences probability of relapse in children with standard-risk acute lymphocytic leukaemia. Evans, W.E., Crom, W.R., Stewart, C.F., Bowman, W.P., Chen, C.H., Abromowitch, M., Simone, J.V. Lancet (1984) [Pubmed]
  34. Development of a standard treatment protocol for severe acute respiratory syndrome. So, L.K., Lau, A.C., Yam, L.Y., Cheung, T.M., Poon, E., Yung, R.W., Yuen, K.Y. Lancet (2003) [Pubmed]
  35. Clinical and microbiological aspects of Trichomonas vaginalis. Petrin, D., Delgaty, K., Bhatt, R., Garber, G. Clin. Microbiol. Rev. (1998) [Pubmed]
  36. IFN-gamma and lipopolysaccharide differentially modulate expression of tumor necrosis factor receptor mRNA in murine peritoneal macrophages. Tannenbaum, C.S., Major, J.A., Hamilton, T.A. J. Immunol. (1993) [Pubmed]
  37. Interleukin-10 treatment can suppress stromal keratitis induced by herpes simplex virus type 1. Tumpey, T.M., Elner, V.M., Chen, S.H., Oakes, J.E., Lausch, R.N. J. Immunol. (1994) [Pubmed]
  38. Clinical and immunomodulatory effects of repetitive 2-day cycles of high-dose continuous infusion IL-2. Engelhardt, M., Wirth, K., Mertelsmann, R., Lindemann, A., Brennscheidt, U. Eur. J. Cancer (1997) [Pubmed]
  39. Serum levels of soluble IL-2 receptor alpha, IL-6 and IL-1 receptor antagonist in schizophrenia before and during neuroleptic administration. Akiyama, K. Schizophr. Res. (1999) [Pubmed]
  40. Structural and biological features of the TNF receptor and TNF ligand superfamilies: interactive signals in the pathobiology of Hodgkin's disease. Gruss, H.J., Duyster, J., Herrmann, F. Ann. Oncol. (1996) [Pubmed]
  41. Beneficial effects of captopril in acute coxsackievirus B3 murine myocarditis. Rezkalla, S., Kloner, R.A., Khatib, G., Khatib, R. Circulation (1990) [Pubmed]
  42. Concurrent radiation therapy and chemotherapy for locally unresectable squamous cell head and neck cancer: an Eastern Cooperative Oncology Group pilot study. Adelstein, D.J., Kalish, L.A., Adams, G.L., Wagner, H., Oken, M.M., Remick, S.C., Mansour, E.G., Haselow, R.E. J. Clin. Oncol. (1993) [Pubmed]
  43. Roscovitine is an effective inducer of apoptosis of Ewing's sarcoma family tumor cells in vitro and in vivo. Tirado, O.M., Mateo-Lozano, S., Notario, V. Cancer Res. (2005) [Pubmed]
  44. Vasopeptidase inhibition affords greater renoprotection than angiotensin-converting enzyme inhibition alone. Taal, M.W., Nenov, V.D., Wong, W., Satyal, S.R., Sakharova, O., Choi, J.H., Troy, J.L., Brenner, B.M. J. Am. Soc. Nephrol. (2001) [Pubmed]
  45. Adenovirus-mediated factor VIII gene expression results in attenuated anti-factor VIII-specific immunity in hemophilia A mice compared with factor VIII protein infusion. Bristol, J.A., Gallo-Penn, A., Andrews, J., Idamakanti, N., Kaleko, M., Connelly, S. Hum. Gene Ther. (2001) [Pubmed]
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