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Sprague, R.S. et al.

Randy S. Sprague, Mary L. Ellsworth,

Vascular disease in pre-diabetes: new insights derived from systems biology.

In many cases vascular disease is present before the clinical onset of type 2 diabetes, that is, during the pre-diabetic period when insulin levels are markedly increased. In pre-diabetes, microvascular dysfunction correlates with plasma insulin levels and not blood glucose. Here we discuss the concept that insulin, at levels found in pre-diabetes, contributes to microvascular disease in skeletal muscle by inhibiting the release of the vasodilator, adenosine triphosphate (ATP), from erythrocytes.[1]

References

Vascular disease in pre-diabetes: new insights derived from systems biology. Sprague, R.S., Ellsworth, M.L. Mo. Med (2010) [Pubmed]

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