High impact information on Systems Biology

• Computational modeling of the EGF-receptor system: a paradigm for systems biology [1].
• Strain improvement by metabolic engineering: lysine production as a case study for systems biology [2].
• By detailing the global NO metrics of a unique coxib bearing a popular NO-donor pharmacophore (i.e., a nitrate moiety) and defining some critical mechanistic determinants, this study demonstrates how NObonomics can serve as valuable tool in helping elucidate NO systems biology and the effect of NO-donor and non-NO-donating therapeutics thereon [3].
• The target gene and protein expression patterns of VDR, PPARs, and PXR; the resulting changes in metabolite levels; and their physiological consequences create a network that can be monitored by high-throughput methods and analyzed by multimodal approaches, such as systems biology [4].
• When kinases meet mathematics: the systems biology of MAPK signalling [5].

Biological context of Systems Biology

• A systems biology approach for the study of cumulative oncogenes with applications to the MAPK signal transduction pathway [6].
• In this review, we analyze current literature on the role of E2F1 in apoptosis and use engineering concepts and a systems biology approach to align the overwhelming amount of contradictory data on this gene [7].

Associations of Systems Biology with chemical compounds

• Cytomics, the human cytome project and systems biology: top-down resolution of the molecular biocomplexity of organisms by single cell analysis [8].
• An integrated omics approach was undertaken in order to elucidate a systems biology level understanding of the acute hepatotoxcity of valproic acid (VPA) [9].
• Galactose utilization in yeast, and sea urchin development are two examples of emerging systems biology [10].
• BACKGROUND: DopaNet http://www.dopanet.org is a Systems Biology initiative that aims to investigate precisely and quantitatively all the aspects of neurotransmission in a specific neuronal system, the mesotelencephalic dopamine system [11].

Gene context of Systems Biology

• Over the last decade, epidermal growth factor (EGF) signaling has been used repeatedly as a test-bed for pioneering computational systems biology [12].
• Then we used a systems biology approach to analyze expression patterns in biochemical pathways and networks to isolate systems involved in hypertension pathology in both SHR and BPH [13].

References