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MeSH Review

Vascular Diseases

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Disease relevance of Vascular Diseases


Psychiatry related information on Vascular Diseases


High impact information on Vascular Diseases

  • US28-mediated SMC migration provides a molecular basis for the correlative evidence that links HCMV to the acceleration of vascular disease [11].
  • Hence, vascular disease in MFS is thought to result when FBN1 mutations preclude elastic fibre maturation by disrupting microfibrillar assembly [12].
  • Because ELN mutations cause vascular disease but not cognitive abnormalities, these data implicate LIMK1 hemizygosity in imparied visuospatial constructive cognition [13].
  • Here we describe two families with a partial WS phenotype; affected members have the specific WS cognitive profile and vascular disease, but lack other WS features [13].
  • This mutation in MTHFR may represent an important genetic risk factor in vascular disease [14].

Chemical compound and disease context of Vascular Diseases


Biological context of Vascular Diseases


Anatomical context of Vascular Diseases

  • OBJECTIVES--To determine the risk of elevated total homocysteine (tHcy) levels for arteriosclerotic vascular disease, estimate the reduction of tHcy by folic acid, and calculate the potential reduction of coronary artery disease (CAD) mortality by increasing folic acid intake [23].
  • Intracellular signaling pathways activated by both PDGF and basic fibroblast growth factor (bFGF) have been implicated in the migration of vascular smooth muscle cells (VSMC), a key step in the pathogenesis of many vascular diseases [24].
  • Increased elastase activity and deposition of the matrix glycoprotein tenascin-C (TN), codistributing with proliferating smooth muscle cells (SMCs), are features of pulmonary vascular disease [25].
  • These results provide the first evidence that monocytes signal VSMCs by mechanisms involving the fibrinolytic system, and they imply an important link between the uPA/uPAR-related signaling machinery and human vascular disease [26].
  • Atherosclerosis can be defined in broad terms as a vascular disease accompanied by dysregulation of cholesterol metabolism and the accumulation of smooth muscle cells and macrophages within the vessel wall [27].

Gene context of Vascular Diseases


Analytical, diagnostic and therapeutic context of Vascular Diseases


  1. Hyperhomocysteinemia: an independent risk factor for vascular disease. Clarke, R., Daly, L., Robinson, K., Naughten, E., Cahalane, S., Fowler, B., Graham, I. N. Engl. J. Med. (1991) [Pubmed]
  2. Correction of disease-causing CBS mutations in yeast. Shan, X., Kruger, W.D. Nat. Genet. (1998) [Pubmed]
  3. Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity. Harvey, N.L., Srinivasan, R.S., Dillard, M.E., Johnson, N.C., Witte, M.H., Boyd, K., Sleeman, M.W., Oliver, G. Nat. Genet. (2005) [Pubmed]
  4. The effect of a subnormal vitamin B-6 status on homocysteine metabolism. Ubbink, J.B., van der Merwe, A., Delport, R., Allen, R.H., Stabler, S.P., Riezler, R., Vermaak, W.J. J. Clin. Invest. (1996) [Pubmed]
  5. Nigral endothelial dysfunction, homocysteine, and Parkinson's disease. Müller, T., Werne, B., Fowler, B., Kuhn, W. Lancet (1999) [Pubmed]
  6. P300 latency in geriatric depression. Kalayam, B., Alexopoulos, G.S., Kindermann, S., Kakuma, T., Brown, G.G., Young, R.C. The American journal of psychiatry. (1998) [Pubmed]
  7. Breakfast cereal fortified with folic acid, vitamin B-6, and vitamin B-12 increases vitamin concentrations and reduces homocysteine concentrations: a randomized trial. Tucker, K.L., Olson, B., Bakun, P., Dallal, G.E., Selhub, J., Rosenberg, I.H. Am. J. Clin. Nutr. (2004) [Pubmed]
  8. Increased concentrations of homocysteine and asymmetric dimethylarginine and decreased concentrations of nitric oxide in the plasma of patients with Alzheimer's disease. Selley, M.L. Neurobiol. Aging (2003) [Pubmed]
  9. Effects of lipo-prostaglandin E1 on pulmonary hemodynamics and clinical outcomes in patients with pulmonary arterial hypertension. Shen, J., He, B., Wang, B. Chest (2005) [Pubmed]
  10. Clinical characteristics of adult epilepsy patients in the 1997 Hong Kong epilepsy registry. Ng, K.K., Ng, P.W., Tsang, K.L. Chin. Med. J. (2001) [Pubmed]
  11. The human cytomegalovirus chemokine receptor US28 mediates vascular smooth muscle cell migration. Streblow, D.N., Soderberg-Naucler, C., Vieira, J., Smith, P., Wakabayashi, E., Ruchti, F., Mattison, K., Altschuler, Y., Nelson, J.A. Cell (1999) [Pubmed]
  12. Targetting of the gene encoding fibrillin-1 recapitulates the vascular aspect of Marfan syndrome. Pereira, L., Andrikopoulos, K., Tian, J., Lee, S.Y., Keene, D.R., Ono, R., Reinhardt, D.P., Sakai, L.Y., Biery, N.J., Bunton, T., Dietz, H.C., Ramirez, F. Nat. Genet. (1997) [Pubmed]
  13. LIM-kinase1 hemizygosity implicated in impaired visuospatial constructive cognition. Frangiskakis, J.M., Ewart, A.K., Morris, C.A., Mervis, C.B., Bertrand, J., Robinson, B.F., Klein, B.P., Ensing, G.J., Everett, L.A., Green, E.D., Pröschel, C., Gutowski, N.J., Noble, M., Atkinson, D.L., Odelberg, S.J., Keating, M.T. Cell (1996) [Pubmed]
  14. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Frosst, P., Blom, H.J., Milos, R., Goyette, P., Sheppard, C.A., Matthews, R.G., Boers, G.J., den Heijer, M., Kluijtmans, L.A., van den Heuvel, L.P. Nat. Genet. (1995) [Pubmed]
  15. Nitric oxide and vascular disease. Loscalzo, J. N. Engl. J. Med. (1995) [Pubmed]
  16. Current concepts in ophthalmology. Retinal vascular diseases. Patz, A. N. Engl. J. Med. (1978) [Pubmed]
  17. Acetylcholine and bradykinin relax intrapulmonary arteries by acting on endothelial cells: role in lung vascular diseases. Chand, N., Altura, B.M. Science (1981) [Pubmed]
  18. Inhibition of neointimal cell bcl-x expression induces apoptosis and regression of vascular disease. Pollman, M.J., Hall, J.L., Mann, M.J., Zhang, L., Gibbons, G.H. Nat. Med. (1998) [Pubmed]
  19. Adiponectin: Identification, physiology and clinical relevance in metabolic and vascular disease. Matsuzawa, Y. Atherosclerosis. Supplements. (2005) [Pubmed]
  20. Diabetic LDL inhibits cell-cycle progression via STAT5B and p21(waf). Brizzi, M.F., Dentelli, P., Pavan, M., Rosso, A., Gambino, R., Grazia De Cesaris, M., Garbarino, G., Camussi, G., Pagano, G., Pegoraro, L. J. Clin. Invest. (2002) [Pubmed]
  21. The nature and determinants of neuropsychological functioning in late-life depression. Butters, M.A., Whyte, E.M., Nebes, R.D., Begley, A.E., Dew, M.A., Mulsant, B.H., Zmuda, M.D., Bhalla, R., Meltzer, C.C., Pollock, B.G., Reynolds, C.F., Becker, J.T. Arch. Gen. Psychiatry (2004) [Pubmed]
  22. Angiotensin-converting enzyme inhibition suppresses plasminogen activator inhibitor-1 expression in the neointima of balloon-injured rat aorta. Hamdan, A.D., Quist, W.C., Gagne, J.B., Feener, E.P. Circulation (1996) [Pubmed]
  23. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. Boushey, C.J., Beresford, S.A., Omenn, G.S., Motulsky, A.G. JAMA (1995) [Pubmed]
  24. Intracellular signaling pathways required for rat vascular smooth muscle cell migration. Interactions between basic fibroblast growth factor and platelet-derived growth factor. Bilato, C., Pauly, R.R., Melillo, G., Monticone, R., Gorelick-Feldman, D., Gluzband, Y.A., Sollott, S.J., Ziman, B., Lakatta, E.G., Crow, M.T. J. Clin. Invest. (1995) [Pubmed]
  25. Regression of hypertrophied rat pulmonary arteries in organ culture is associated with suppression of proteolytic activity, inhibition of tenascin-C, and smooth muscle cell apoptosis. Cowan, K.N., Jones, P.L., Rabinovitch, M. Circ. Res. (1999) [Pubmed]
  26. Monocyte-expressed urokinase inhibits vascular smooth muscle cell growth by activating Stat1. Kunigal, S., Kusch, A., Tkachuk, N., Tkachuk, S., Jerke, U., Haller, H., Dumler, I. Blood (2003) [Pubmed]
  27. Signal transduction in atherosclerosis: integration of cytokines and the eicosanoid network. Hajjar, D.P., Pomerantz, K.B. FASEB J. (1992) [Pubmed]
  28. Direct binding of Nur77/NAK-1 to the plasminogen activator inhibitor 1 (PAI-1) promoter regulates TNF alpha -induced PAI-1 expression. Gruber, F., Hufnagl, P., Hofer-Warbinek, R., Schmid, J.A., Breuss, J.M., Huber-Beckmann, R., Lucerna, M., Papac, N., Harant, H., Lindley, I., de Martin, R., Binder, B.R. Blood (2003) [Pubmed]
  29. Plasminogen activator inhibitor-1 deficiency protects against atherosclerosis progression in the mouse carotid artery. Eitzman, D.T., Westrick, R.J., Xu, Z., Tyson, J., Ginsburg, D. Blood (2000) [Pubmed]
  30. CYR61 (CCN1) is essential for placental development and vascular integrity. Mo, F.E., Muntean, A.G., Chen, C.C., Stolz, D.B., Watkins, S.C., Lau, L.F. Mol. Cell. Biol. (2002) [Pubmed]
  31. Oncostatin M induces interleukin-6 and cyclooxygenase-2 expression in human vascular smooth muscle cells : synergy with interleukin-1beta. Bernard, C., Merval, R., Lebret, M., Delerive, P., Dusanter-Fourt, I., Lehoux, S., Créminon, C., Staels, B., Maclouf, J., Tedgui, A. Circ. Res. (1999) [Pubmed]
  32. Novel role of the membrane-bound chemokine fractalkine in platelet activation and adhesion. Schäfer, A., Schulz, C., Eigenthaler, M., Fraccarollo, D., Kobsar, A., Gawaz, M., Ertl, G., Walter, U., Bauersachs, J. Blood (2004) [Pubmed]
  33. Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project. Graham, I.M., Daly, L.E., Refsum, H.M., Robinson, K., Brattström, L.E., Ueland, P.M., Palma-Reis, R.J., Boers, G.H., Sheahan, R.G., Israelsson, B., Uiterwaal, C.S., Meleady, R., McMaster, D., Verhoef, P., Witteman, J., Rubba, P., Bellet, H., Wautrecht, J.C., de Valk, H.W., Sales Lúis, A.C., Parrot-Rouland, F.M., Tan, K.S., Higgins, I., Garcon, D., Andria, G. JAMA (1997) [Pubmed]
  34. Reversal of experimental pulmonary hypertension by PDGF inhibition. Schermuly, R.T., Dony, E., Ghofrani, H.A., Pullamsetti, S., Savai, R., Roth, M., Sydykov, A., Lai, Y.J., Weissmann, N., Seeger, W., Grimminger, F. J. Clin. Invest. (2005) [Pubmed]
  35. The helical domain of GBP-1 mediates the inhibition of endothelial cell proliferation by inflammatory cytokines. Guenzi, E., Töpolt, K., Cornali, E., Lubeseder-Martellato, C., Jörg, A., Matzen, K., Zietz, C., Kremmer, E., Nappi, F., Schwemmle, M., Hohenadl, C., Barillari, G., Tschachler, E., Monini, P., Ensoli, B., Stürzl, M. EMBO J. (2001) [Pubmed]
  36. Applying apoB to the diagnosis and therapy of the atherogenic dyslipoproteinemias: a clinical diagnostic algorithm. Sniderman, A.D. Curr. Opin. Lipidol. (2004) [Pubmed]
  37. Role of platelet-derived growth factor in allograft vasculopathy. Mancini, M.C., Evans, J.T. Ann. Surg. (2000) [Pubmed]
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