The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Atriphos     [[[(2R,3S,4R,5R)-5-(6- aminopurin-9-yl)-3,4...

Synonyms: Adephos, Fosfobion, Striadyne, Triadenyl, Adetol, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Adenosine triphosphate


Psychiatry related information on Adenosine triphosphate


High impact information on Adenosine triphosphate

  • The HSP90-based chaperone machine is driven by the hydrolysis of ATP and ADP/ATP nucleotide exchange [7].
  • In a process analogous to enzymatic nitrogen reduction, BCR couples the electron transfer to the aromatic ring to a stoichiometric hydrolysis of 2 ATP/2e(-) [8].
  • Noninvasive diagnosis of dual AV node physiology in patients with AV nodal reentrant tachycardia by administration of adenosine-5'-triphosphate during sinus rhythm [9].
  • Inhibition of ADA activity was found in all except one patient at 4 to 24 hours after the first administration of DCF. dATP started to accumulate at four hours, reached a maximum level between 24 and 48 hours, and returned to base values on the fifth day [10].
  • The human erythrocyte actively phosphorylates and dephosphorylates phosphatidylinositol present in the membrane in an apparent "futile cycle." Recent reports have proposed that this phosphorylation/dephosphorylation cycle is a significant consumer of adenosine-5'-triphosphate (ATP) in the erythrocyte [11].

Chemical compound and disease context of Adenosine triphosphate


Biological context of Adenosine triphosphate


Anatomical context of Adenosine triphosphate


Associations of Adenosine triphosphate with other chemical compounds

  • OBJECTIVE: Adenine compounds, including adenosine-5'-triphosphate (ATP) and adenosine (Ado), exert inhibitory effects on myocardium via P1 (subtype A1) purinoceptors [25].
  • 2. ATP blocked 88 and 61 % of the outward and inward components of the volume-activated chloride current (ICl,vol) with an IC50 of 5.3 and 9.6 mM, respectively [26].
  • 5. The stoichiometric ratio between potassium uptake and ATP as calculated from lactate release approximated theoretical values of 2:1 (assuming 1 ATP per lactate) when potassium re-entry concentrations were less than 2 mM; higher concentrations of potassium produced ratios up to 9:1 [27].
  • 1. Patch-clamp methods were used to study the action of tetraethylammonium ions (TEA+) and other quaternary ammonium ions on adenosine-5'-triphosphate (ATP)-sensitive K+ channels in sarcolemmal vesicles from frog skeletal muscle [28].
  • OCLs were treated with 5,6-dichloro-1 beta-D-ribofuranosyl benzimidazole to enable estimation of the mRNA decay rates in the absence of ongoing transcription [29].

Gene context of Adenosine triphosphate


Analytical, diagnostic and therapeutic context of Adenosine triphosphate


  1. Electrophysiologic effects of adenosine-5'-triphosphate on atrioventricular reentrant tachycardia. Belhassen, B., Pelleg, A., Shoshani, D., Geva, B., Laniado, S. Circulation (1983) [Pubmed]
  2. Glutamine- and phosphate-containing hypotonic storage media better maintain erythrocyte membrane physical properties. Dumaswala, U.J., Wilson, M.J., José, T., Daleke, D.L. Blood (1996) [Pubmed]
  3. Inhibitory effects of 9-beta-D-arabinofuranosylguanine 5'-triphosphate and 9-beta-D-arabinofuranosyladenine 5'-triphosphate on DNA polymerases from murine cells and oncornavirus. Ono, K., Ohashi, A., Yamamoto, A., Matsukage, A., Takahasi, T., Saneyoshi, M., Ueda, T. Cancer Res. (1979) [Pubmed]
  4. Inhibition of nuclear envelope nucleoside triphosphatase-regulated nucleocytoplasmic messenger RNA translocation by 9-beta-D-arabinofuranosyladenine 5'-triphosphate in rodent cells. Schröder, H.C., Nitzgen, D.E., Bernd, A., Kurelec, B., Zahn, R.K., Gramzow, M., Müller, W.E. Cancer Res. (1984) [Pubmed]
  5. Modulation of 9-beta-D-arabinofuranosyladenine 5'-triphosphate and deoxyadenosine triphosphate in leukemic cells by 2'-deoxycoformycin during therapy with 9-beta-D-arabinofuranosyladenine. Plunkett, W., Benjamin, R.S., Keating, M.J., Freireich, E.J. Cancer Res. (1982) [Pubmed]
  6. Apoptosis and necrosis: two types of cell death in alcoholic liver disease. Nanji, A.A., Hiller-Sturmhöfel, S. Alcohol health and research world. (1997) [Pubmed]
  7. Inhibitors of the HSP90 molecular chaperone: current status. Sharp, S., Workman, P. Adv. Cancer Res. (2006) [Pubmed]
  8. Mechanism of ATP-driven electron transfer catalyzed by the benzene ring-reducing enzyme benzoyl-CoA reductase. Unciuleac, M., Boll, M. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  9. Noninvasive diagnosis of dual AV node physiology in patients with AV nodal reentrant tachycardia by administration of adenosine-5'-triphosphate during sinus rhythm. Belhassen, B., Fish, R., Glikson, M., Glick, A., Eldar, M., Laniado, S., Viskin, S. Circulation (1998) [Pubmed]
  10. Clinical response to deoxycoformycin in chronic lymphoid neoplasms and biochemical changes in circulating malignant cells in vivo. Ho, A.D., Ganeshaguru, K., Knauf, W.U., Dietz, G., Trede, I., Hunstein, W., Hoffbrand, A.V. Blood (1988) [Pubmed]
  11. Quantitation of adenosine-5'-triphosphate used for phosphoinositide metabolism in human erythrocytes. Dale, G.L. Blood (1985) [Pubmed]
  12. Dipyridamole enhancement of toxicity to L1210 cells by deoxyadenosine and deoxycoformycin combinations in vitro. Kang, G.J., Kimball, A.P. Cancer Res. (1984) [Pubmed]
  13. Phorphorylative electron transport chains lacking a cytochrome bc1 complex. Kröger, A., Paulsen, J., Schröder, I. J. Bioenerg. Biomembr. (1986) [Pubmed]
  14. The proton-translocating adenosine triphosphatase of the obligately anaerobic bacterium Clostridium pasteurianum. 2. ATP synthetase activity. Clarke, D.J., Morris, J.G. Eur. J. Biochem. (1979) [Pubmed]
  15. Oxygen and substrate deprivation on isolated rat cardiac myocytes: temporal relationship between electromechanical and biochemical consequences. Fantini, E., Athias, P., Courtois, M., Khatami, S., Grynberg, A., Chevalier, A. Can. J. Physiol. Pharmacol. (1990) [Pubmed]
  16. Enzymatic adenylylation of spectinomycin by Acinetobacter calcoaceticus subsp. anitratus. Shimizu, S., Inoue, M., Mitsuhashi, S., Naganawa, H., Kondo, S. J. Antibiot. (1981) [Pubmed]
  17. Fluorescence imaging of extracellular purinergic receptor sites and putative ecto-ATPase sites on isolated cochlear hair cells. Mockett, B.G., Housley, G.D., Thorne, P.R. J. Neurosci. (1994) [Pubmed]
  18. Astrocyte-derived ATP induces vesicle shedding and IL-1 beta release from microglia. Bianco, F., Pravettoni, E., Colombo, A., Schenk, U., Möller, T., Matteoli, M., Verderio, C. J. Immunol. (2005) [Pubmed]
  19. Thermodynamic limits to the ATP/site stoichiometries of oxidative phosphorylation by rat liver mitochondria. Lemasters, J.J., Grunwald, R., Emaus, R.K. J. Biol. Chem. (1984) [Pubmed]
  20. Ara-ATP impairs 3'-end processing of pre-mRNAs by inhibiting both cleavage and polyadenylation. Ghoshal, K., Jacob, S.T. Nucleic Acids Res. (1991) [Pubmed]
  21. Oxidative stress and Mrp2 internalization. Sekine, S., Ito, K., Horie, T. Free Radic. Biol. Med. (2006) [Pubmed]
  22. Resistance to 9-beta-D-arabinofuranosyladenine in murine tumor cells. LePage, G.A. Cancer Res. (1978) [Pubmed]
  23. Cardiovascular effects of sulphonylurea derivatives. Implications for the treatment of NIDDM? Smits, P., Thien, T. Diabetologia (1995) [Pubmed]
  24. Studies of the unitary properties of adenosine-5'-triphosphate-regulated potassium channels of frog skeletal muscle. Spruce, A.E., Standen, N.B., Stanfield, P.R. J. Physiol. (Lond.) (1987) [Pubmed]
  25. P2 purinoceptors contribute to ATP-induced inhibition of L-type Ca2+ current in rabbit atrial myocytes. Yamamoto, T., Habuchi, Y., Nishio, M., Morikawa, J., Tanaka, H. Cardiovasc. Res. (1999) [Pubmed]
  26. The role of ClC-3 in volume-activated chloride currents and volume regulation in bovine epithelial cells demonstrated by antisense inhibition. Wang, L., Chen, L., Jacob, T.J. J. Physiol. (Lond.) (2000) [Pubmed]
  27. The nature of fuel provision for the Na+,K(+)-ATPase in porcine vascular smooth muscle. Campbell, J.D., Paul, R.J. J. Physiol. (Lond.) (1992) [Pubmed]
  28. Multiple blocking mechanisms of ATP-sensitive potassium channels of frog skeletal muscle by tetraethylammonium ions. Davies, N.W., Spruce, A.E., Standen, N.B., Stanfield, P.R. J. Physiol. (Lond.) (1989) [Pubmed]
  29. Regulation by calcitonin and glucocorticoids of calcitonin receptor gene expression in mouse osteoclasts. Wada, S., Udagawa, N., Akatsu, T., Nagata, N., Martin, T.J., Findlay, D.M. Endocrinology (1997) [Pubmed]
  30. The effect of DNA mismatches on the ATPase activity of MSH1, a protein in yeast mitochondria that recognizes DNA mismatches. Chi, N.W., Kolodner, R.D. J. Biol. Chem. (1994) [Pubmed]
  31. Extrinsic origin of the capsaicin-sensitive innervation of rat duodenum: possible involvement of calcitonin gene-related peptide (CGRP) in the capsaicin-induced activation of intramural non-adrenergic non-cholinergic neurons. Maggi, C.A., Manzini, S., Giuliani, S., Santicioli, P., Meli, A. Naunyn Schmiedebergs Arch. Pharmacol. (1986) [Pubmed]
  32. Molecular mechanisms of androgenetic alopecia. Trüeb, R.M. Exp. Gerontol. (2002) [Pubmed]
  33. Intrinsic inhibition of the hsp90 ATPase activity. Richter, K., Moser, S., Hagn, F., Friedrich, R., Hainzl, O., Heller, M., Schlee, S., Kessler, H., Reinstein, J., Buchner, J. J. Biol. Chem. (2006) [Pubmed]
  34. Alternative splicing of the multidrug resistance protein 1/ATP binding cassette transporter subfamily gene in ovarian cancer creates functional splice variants and is associated with increased expression of the splicing factors PTB and SRp20. He, X., Ee, P.L., Coon, J.S., Beck, W.T. Clin. Cancer Res. (2004) [Pubmed]
  35. ATP activates non-selective cation channels and calcium release in inner hair cells of the guinea-pig cochlea. Sugasawa, M., Erostegui, C., Blanchet, C., Dulon, D. J. Physiol. (Lond.) (1996) [Pubmed]
  36. Characterization of a P2X-purinoceptor in cultured neurones of the rat dorsal root ganglia. Robertson, S.J., Rae, M.G., Rowan, E.G., Kennedy, C. Br. J. Pharmacol. (1996) [Pubmed]
  37. Interaction between adenosine triphosphate and noradrenaline in the isolated vas deferens of the guinea-pig. Kazić, T., Milosavljević, D. Br. J. Pharmacol. (1980) [Pubmed]
  38. Acute sinoaortic denervation induces pre- and postsynaptic alpha-adrenergic subsensitivity in mesenteric arteries in the rat. Granata, A.R. Neuropharmacology (1984) [Pubmed]
WikiGenes - Universities