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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Effects of maternal exposure to trioxane on postnatal development in rats.

Female rats were given by gavage every other day from days 2 to 20 of gestation an aqueous solution of trioxane at daily doses equal to 0.025; 0.075 and 0.15 LD50 (0.19: 0.58 and 1.16 g/kg). Maternal exposure to trioxane at the highest dose resulted in death of most neonates a few days after birth. Viability and postnatal growth of the offspring of dams that were given 0.19 and 0.58 g/kg were not affected. Transitional depression of exploratory locomotor activity in female offspring and a decrease of active avoidance acquisition were observed in adult male and female offspring from the 0.58 g/kg group, whereas a dose of 0.19 g trioxane /kg did not affect the behavioral performance of progeny.[1]


  1. Effects of maternal exposure to trioxane on postnatal development in rats. Sitarek, K., Barański, B. Polish journal of occupational medicine. (1990) [Pubmed]
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