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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Maternal Exposure

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Disease relevance of Maternal Exposure


Psychiatry related information on Maternal Exposure

  • Maternal exposure is assessed relative to specific tobacco-related chemicals and the feto-placental impact of mutagenic products, in addition to nicotine replacement as a pharmacological intervention for smoking cessation [6].

High impact information on Maternal Exposure


Chemical compound and disease context of Maternal Exposure


Biological context of Maternal Exposure


Anatomical context of Maternal Exposure


Associations of Maternal Exposure with chemical compounds


Gene context of Maternal Exposure

  • Effects of the GSTM1 and GSTT1 polymorphisms on the relationship between maternal exposure to environmental tobacco smoke and neonatal birth weight [31].
  • These results suggest that maternal exposure to real-life levels of nicotine and/or chlorpyrifos causes differential regulation of brainstem AChE activity [32].
  • Changes in TNFalpha, BDNF, and NGF after maternal exposure to poly I:C represent a potential mechanism through which maternal infection increases risk for neurodevelopmental disorders [33].
  • Maternal exposure to solvents (OR 3.1, 95% CI 1.0-9.7) and plastic materials (OR 6.9, 95% CI 1.2-39.7) during pregnancy and plastic materials after pregnancy (OR 8.3, 95% CI 1.4-48.8) were related to K-ras mutation [34].
  • This finding indicates that the perinatal opiate syndrome associated with maternal exposure to methadone is caused by the inhibition in MAO-A development in monoaminergic neurons in the brain [35].

Analytical, diagnostic and therapeutic context of Maternal Exposure


  1. Birth defects following maternal exposure to ergotamine, beta blockers, and caffeine. Hughes, H.E., Goldstein, D.A. J. Med. Genet. (1988) [Pubmed]
  2. Maternal exposure to tamoxifen during pregnancy increases carcinogen-induced mammary tumorigenesis among female rat offspring. Halakivi-Clarke, L., Cho, E., Onojafe, I., Liao, D.J., Clarke, R. Clin. Cancer Res. (2000) [Pubmed]
  3. Spectrum of neural-tube defects in 34 infants prenatally exposed to antiepileptic drugs. Lindhout, D., Omtzigt, J.G., Cornel, M.C. Neurology (1992) [Pubmed]
  4. Effect of Salmonella endotoxin administered to the pregnant sheep at 133-142 days gestation on fetal oxygenation, maternal and fetal adrenocorticotropic hormone and cortisol, and maternal plasma tumor necrosis factor alpha concentrations. Schlafer, D.H., Yuh, B., Foley, G.L., Elssaser, T.H., Sadowsky, D., Nathanielsz, P.W. Biol. Reprod. (1994) [Pubmed]
  5. Behavioral toxicity in the offspring of rats following maternal exposure to dichloromethane. Bornschein, R.L., Hastings, L., Manson, J.M. Toxicol. Appl. Pharmacol. (1980) [Pubmed]
  6. Cigarette smoking and pregnancy I: ovarian, uterine and placental effects. Shiverick, K.T., Salafia, C. Placenta (1999) [Pubmed]
  7. Losartan and fetal toxic effects. Saji, H., Yamanaka, M., Hagiwara, A., Ijiri, R. Lancet (2001) [Pubmed]
  8. Letter: Cardiovascular maldevelopment associated with maternal exposure to amantadine. Nora, J.J., Nora, A.H., Way, G.L. Lancet (1975) [Pubmed]
  9. Transplacental chemical exposure and risk of infant leukemia with MLL gene fusion. Alexander, F.E., Patheal, S.L., Biondi, A., Brandalise, S., Cabrera, M.E., Chan, L.C., Chen, Z., Cimino, G., Cordoba, J.C., Gu, L.J., Hussein, H., Ishii, E., Kamel, A.M., Labra, S., Magalhães, I.Q., Mizutani, S., Petridou, E., de Oliveira, M.P., Yuen, P., Wiemels, J.L., Greaves, M.F. Cancer Res. (2001) [Pubmed]
  10. Developmental pharmacology and toxicology of anti-HIV therapeutic agents: dideoxynucleosides. Sandberg, J.A., Slikker, W. FASEB J. (1995) [Pubmed]
  11. Acyclovir in Pregnancy Registry. An observational epidemiologic approach. Andrews, E.B., Tilson, H.H., Hurn, B.A., Cordero, J.F. Am. J. Med. (1988) [Pubmed]
  12. Fetal testosterone in mice: effect of gestational age and cannabinoid exposure. Dalterio, S., Bartke, A. J. Endocrinol. (1981) [Pubmed]
  13. Clear cell adenocarcinoma of the lower genital tract. Correlation of mother's recall of diethylstilbestrol history with obstetrical records. Sharp, G.B., Cole, P., Anderson, D., Herbst, A.L. Cancer (1990) [Pubmed]
  14. Induction of hypospadias in a murine model by maternal exposure to synthetic estrogens. Kim, K.S., Torres, C.R., Yucel, S., Raimondo, K., Cunha, G.R., Baskin, L.S. Environmental research. (2004) [Pubmed]
  15. Pregnancy outcomes following pre- and post-implantation exposure of Sprague-Dawley rats to benzyl isothiocyanate. Adebiyi, A., Adaikan, P.G., Prasad, R.N. Food Chem. Toxicol. (2004) [Pubmed]
  16. The fungicide propiconazole interferes with embryonic development of the crustacean Daphnia magna. Kast-Hutcheson, K., Rider, C.V., LeBlanc, G.A. Environ. Toxicol. Chem. (2001) [Pubmed]
  17. Maternal exposure to octylphenol suppresses ovine fetal follicle-stimulating hormone secretion, testis size, and sertoli cell number. Sweeney, T., Nicol, L., Roche, J.F., Brooks, A.N. Endocrinology (2000) [Pubmed]
  18. Passive and active maternal smoking as measured by serum cotinine: the effect on birthweight. Eskenazi, B., Prehn, A.W., Christianson, R.E. American journal of public health. (1995) [Pubmed]
  19. An aminopterin-like syndrome without aminopterin (ASSAS). Fraser, F.C., Anderson, R.A., Mulvihill, J.I., Preus, M. Clin. Genet. (1987) [Pubmed]
  20. Pharmacokinetics of betamethasone after maternal or fetal intramuscular administration. Moss, T.J., Doherty, D.A., Nitsos, I., Harding, R., Newnham, J.P. Am. J. Obstet. Gynecol. (2003) [Pubmed]
  21. Transplacental pharmacokinetics and maternal/fetal plasma concentrations of cocaine in pregnant macaques near term. Binienda, Z., Bailey, J.R., Duhart, H.M., Slikker, W., Paule, M.G. Drug Metab. Dispos. (1993) [Pubmed]
  22. Clinical pharmacokinetics of naproxen. Davies, N.M., Anderson, K.E. Clinical pharmacokinetics. (1997) [Pubmed]
  23. Induction of calbindin-D9k messenger RNA and protein by maternal exposure to alkylphenols during late pregnancy in maternal and neonatal uteri of rats. Hong, E.J., Choi, K.C., Jeung, E.B. Biol. Reprod. (2004) [Pubmed]
  24. Ultrastructural observations on rabbit blastocysts after maternal exposure to cadmium chloride. Abraham, R., Ringwood, N., Mankes, R. J. Reprod. Fertil. (1984) [Pubmed]
  25. Biologically based dose-response modeling in developmental toxicology: biochemical and cellular sequelae of 5-fluorouracil exposure in the developing rat. Shuey, D.L., Lau, C., Logsdon, T.R., Zucker, R.M., Elstein, K.H., Narotsky, M.G., Setzer, R.W., Kavlock, R.J., Rogers, J.M. Toxicol. Appl. Pharmacol. (1994) [Pubmed]
  26. Developmental toxicity of bromohydroquinone (BHQ) and BHQ-glutathione conjugates in vivo and in whole embryo culture. Andrews, J.E., Rogers, J.M., Ebron-McCoy, M., Logsdon, T.R., Monks, T.J., Lau, S.S. Toxicol. Appl. Pharmacol. (1993) [Pubmed]
  27. The cumulative scanning electron microscopic changes in baby mouse lungs following prenatal and postnatal exposures to nicotine. Wang, N.S., Chen, M.F., Schraufnagel, D.E., Yao, Y.T. J. Pathol. (1984) [Pubmed]
  28. Use of response biomarkers in milk for assessing exposure to environmental contaminants: the case for dioxin-like compounds. Diehl-Jones, W.L., Bols, N.C. Journal of toxicology and environmental health. Part B, Critical reviews. (2000) [Pubmed]
  29. Maternal cesium chloride ingestion and the newborn. Messiha, F.S. Neuroscience and biobehavioral reviews. (1988) [Pubmed]
  30. Fetal pituitary gonadotropin as an initial target of dioxin in its impairment of cholesterol transportation and steroidogenesis in rats. Mutoh, J., Taketoh, J., Okamura, K., Kagawa, T., Ishida, T., Ishii, Y., Yamada, H. Endocrinology (2006) [Pubmed]
  31. Effects of the GSTM1 and GSTT1 polymorphisms on the relationship between maternal exposure to environmental tobacco smoke and neonatal birth weight. Hong, Y.C., Lee, K.H., Son, B.K., Ha, E.H., Moon, H.S., Ha, M. J. Occup. Environ. Med. (2003) [Pubmed]
  32. Maternal exposure to nicotine and chlorpyrifos, alone and in combination, leads to persistently elevated expression of glial fibrillary acidic protein in the cerebellum of the offspring in late puberty. Abdel-Rahman, A., Dechkovskaia, A.M., Mehta-Simmons, H., Sutton, J.M., Guan, X., Khan, W.A., Abou-Donia, M.B. Arch. Toxicol. (2004) [Pubmed]
  33. Maternal poly I:C exposure during pregnancy regulates TNF alpha, BDNF, and NGF expression in neonatal brain and the maternal-fetal unit of the rat. Gilmore, J.H., Jarskog, L.F., Vadlamudi, S. J. Neuroimmunol. (2005) [Pubmed]
  34. Parental exposure to medications and hydrocarbons and ras mutations in children with acute lymphoblastic leukemia: a report from the Children's Oncology Group. Shu, X.O., Perentesis, J.P., Wen, W., Buckley, J.D., Boyle, E., Ross, J.A., Robison, L.L. Cancer Epidemiol. Biomarkers Prev. (2004) [Pubmed]
  35. Effect of maternal methadone administration on the development of multiple forms of monoamine oxidase in rat brain and liver. Tsang, D., Ho, K.P., Wen, H.L. Brain Res. (1986) [Pubmed]
  36. A double-blind randomized study of fetal side effects during and after the short-term maternal administration of indomethacin, sulindac, and nimesulide for the treatment of preterm labor. Sawdy, R.J., Lye, S., Fisk, N.M., Bennett, P.R. Am. J. Obstet. Gynecol. (2003) [Pubmed]
  37. Idiopathic constriction of the fetal ductus arteriosus. Trevett, T.N., Cotton, J. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology. (2004) [Pubmed]
  38. The impact of technical adjuncts in the surgical management of cerebral hemispheric low-grade gliomas of childhood. Berger, M.S. J. Neurooncol. (1996) [Pubmed]
  39. Pathogenesis of cleft palate in Treacher Collins, Nager, and Miller syndromes. Sulik, K.K., Smiley, S.J., Turvey, T.A., Speight, H.S., Johnston, M.C. The Cleft palate journal. (1989) [Pubmed]
  40. Decreased sex ratio following maternal exposure to polychlorinated biphenyls from contaminated Great Lakes sport-caught fish: a retrospective cohort study. Weisskopf, M.G., Anderson, H.A., Hanrahan, L.P. Environmental health : a global access science source [electronic resource]. (2003) [Pubmed]
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