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Van Kuijk, F.J. et al.

4-Hydroxyhexenal: a lipid peroxidation product derived from oxidized docosahexaenoic acid.

4-Hydroxynonenal and 4-hydroxyhexenal are cytotoxic aldehydic products of lipid peroxidation with high biological activity. Peroxidation of n - 6 fatty acids produces 4-hydroxynonenal, but the origin of 4-hydroxyhexenal has been uncertain. We now present evidence that 4-hydroxyhexenal is generated by oxidation of docosahexaenoic acid, the most abundant n-3 fatty acid in tissues.[1]

References

4-Hydroxyhexenal: a lipid peroxidation product derived from oxidized docosahexaenoic acid. Van Kuijk, F.J., Holte, L.L., Dratz, E.A. Biochim. Biophys. Acta (1990) [Pubmed]

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