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Chemical Compound Review

CCRIS 9201     (E)-4-hydroxyhex-2-enal

Synonyms: KB-02504, LS-75538, SBB069586, LMFA06000016, AKOS006273451, ...
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Disease relevance of LMFA06000016


High impact information on LMFA06000016


Biological context of LMFA06000016


Anatomical context of LMFA06000016


Associations of LMFA06000016 with other chemical compounds


Gene context of LMFA06000016


  1. Accumulation of protein-bound 4-hydroxy-2-hexenal in spinal cords from patients with sporadic amyotrophic lateral sclerosis. Shibata, N., Yamada, S., Uchida, K., Hirano, A., Sakoda, S., Fujimura, H., Sasaki, S., Iwata, M., Toi, S., Kawaguchi, M., Yamamoto, T., Kobayashi, M. Brain Res. (2004) [Pubmed]
  2. Genotoxic properties of 4-hydroxyalkenals and analogous aldehydes. Eckl, P.M., Ortner, A., Esterbauer, H. Mutat. Res. (1993) [Pubmed]
  3. In situ detection of oxidized n-3 polyunsaturated fatty acids in chronic hepatitis C: correlation with hepatic steatosis. Kitase, A., Hino, K., Furutani, T., Okuda, M., Gondo, T., Hidaka, I., Hara, Y., Yamaguchi, Y., Okita, K. J. Gastroenterol. (2005) [Pubmed]
  4. Hydroxyalkenal formation induced by advanced glycosylation of low density lipoprotein. Al-Abed, Y., Liebich, H., Voelter, W., Bucala, R. J. Biol. Chem. (1996) [Pubmed]
  5. Induction of endothelial iNOS by 4-hydroxyhexenal through NF-kappaB activation. Lee, J.Y., Je, J.H., Jung, K.J., Yu, B.P., Chung, H.Y. Free Radic. Biol. Med. (2004) [Pubmed]
  6. Inhibition of adenine nucleotide translocator by lipid peroxidation products. Chen, J.J., Bertrand, H., Yu, B.P. Free Radic. Biol. Med. (1995) [Pubmed]
  7. NF-kappaB activation mechanism of 4-hydroxyhexenal via NIK/IKK and p38 MAPK pathway. Je, J.H., Lee, J.Y., Jung, K.J., Sung, B., Go, E.K., Yu, B.P., Chung, H.Y. FEBS Lett. (2004) [Pubmed]
  8. Induction of endothelial apoptosis by 4-hydroxyhexenal. Lee, J.Y., Je, J.H., Kim, D.H., Chung, S.W., Zou, Y., Kim, N.D., Ae Yoo, M., Suck Baik, H., Yu, B.P., Chung, H.Y. Eur. J. Biochem. (2004) [Pubmed]
  9. Toxicity and detoxification of lipid-derived aldehydes in cultured retinal pigmented epithelial cells. Choudhary, S., Xiao, T., Srivastava, S., Zhang, W., Chan, L.L., Vergara, L.A., Van Kuijk, F.J., Ansari, N.H. Toxicol. Appl. Pharmacol. (2005) [Pubmed]
  10. Cytotoxicity, DNA fragmentation and sister-chromatid exchange in Chinese hamster ovary cells exposed to the lipid peroxidation product 4-hydroxynonenal and homologous aldehydes. Brambilla, G., Sciabà, L., Faggin, P., Maura, A., Marinari, U.M., Ferro, M., Esterbauer, H. Mutat. Res. (1986) [Pubmed]
  11. 4-Hydroxyhexenal: a lipid peroxidation product derived from oxidized docosahexaenoic acid. Van Kuijk, F.J., Holte, L.L., Dratz, E.A. Biochim. Biophys. Acta (1990) [Pubmed]
  12. Degradation of glyceraldehyde-3-phosphate dehydrogenase triggered by 4-hydroxy-2-nonenal and 4-hydroxy-2-hexenal. Tsuchiya, Y., Yamaguchi, M., Chikuma, T., Hojo, H. Arch. Biochem. Biophys. (2005) [Pubmed]
  13. Telmisartan inhibits both oxidative stress and renal fibrosis after unilateral ureteral obstruction in acatalasemic mice. Sugiyama, H., Kobayashi, M., Wang, D.H., Sunami, R., Maeshima, Y., Yamasaki, Y., Masuoka, N., Kira, S., Makino, H. Nephrol. Dial. Transplant. (2005) [Pubmed]
  14. Reduction of 4-hydroxynonenal and 4-hydroxyhexenal by retinal aldose reductase. He, Q., Khanna, P., Srivastava, S., van Kuijk, F.J., Ansari, N.H. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
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