Chemical Compound Review:
CHEMBL454280 (E)-4-hydroxynon-2-enal
Synonyms:
CCRIS 1781, CCRIS 6927, CCRIS 9028, CHEBI:32585, CHEBI:58968, ...
- Malondialdehyde and 4-hydroxynonenal protein adducts in plasma and liver of rats with iron overload. Houglum, K., Filip, M., Witztum, J.L., Chojkier, M. J. Clin. Invest. (1990)
- Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease. Yoritaka, A., Hattori, N., Uchida, K., Tanaka, M., Stadtman, E.R., Mizuno, Y. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Induction of rat aortic smooth muscle cell growth by the lipid peroxidation product 4-hydroxy-2-nonenal. Ruef, J., Rao, G.N., Li, F., Bode, C., Patterson, C., Bhatnagar, A., Runge, M.S. Circulation (1998)
- 4-Hydroxynonenal immunoreactivity is increased in human hippocampus after global ischemia. McKracken, E., Graham, D.I., Nilsen, M., Stewart, J., Nicoll, J.A., Horsburgh, K. Brain Pathol. (2001)
- Presence of 4-hydroxynonenal in cerebrospinal fluid of patients with sporadic amyotrophic lateral sclerosis. Smith, R.G., Henry, Y.K., Mattson, M.P., Appel, S.H. Ann. Neurol. (1998)
- Immunohistochemical detection of 4-hydroxy-2-nonenal adducts in Alzheimer's disease is associated with inheritance of APOE4. Montine, K.S., Olson, S.J., Amarnath, V., Whetsell, W.O., Graham, D.G., Montine, T.J. Am. J. Pathol. (1997)
- Astrocytes accumulate 4-hydroxynonenal adducts in murine scrapie and human Creutzfeldt-Jakob disease. Andreoletti, O., Levavasseur, E., Uro-Coste, E., Tabouret, G., Sarradin, P., Delisle, M.B., Berthon, P., Salvayre, R., Schelcher, F., Negre-Salvayre, A. Neurobiol. Dis. (2002)
- Hepatic lipid peroxidation in hereditary hemochromatosis and alcoholic liver injury. Niemelä, O., Parkkila, S., Britton, R.S., Brunt, E., Janney, C., Bacon, B. J. Lab. Clin. Med. (1999)
- Effects of vitamin E on lipid peroxidation in healthy persons. Meagher, E.A., Barry, O.P., Lawson, J.A., Rokach, J., FitzGerald, G.A. JAMA (2001)
- Aldose reductase functions as a detoxification system for lipid peroxidation products in vasculitis. Rittner, H.L., Hafner, V., Klimiuk, P.A., Szweda, L.I., Goronzy, J.J., Weyand, C.M. J. Clin. Invest. (1999)
- Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man. Ylä-Herttuala, S., Palinski, W., Rosenfeld, M.E., Parthasarathy, S., Carew, T.E., Butler, S., Witztum, J.L., Steinberg, D. J. Clin. Invest. (1989)
- Small molecule oxidation products trigger disease-associated protein misfolding. Bieschke, J., Zhang, Q., Bosco, D.A., Lerner, R.A., Powers, E.T., Wentworth, P., Kelly, J.W. Acc. Chem. Res. (2006)
- A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling. Echtay, K.S., Esteves, T.C., Pakay, J.L., Jekabsons, M.B., Lambert, A.J., Portero-Otín, M., Pamplona, R., Vidal-Puig, A.J., Wang, S., Roebuck, S.J., Brand, M.D. EMBO J. (2003)
- Acetaldehyde-modified and 4-hydroxynonenal-modified proteins in the livers of rats with alcoholic liver disease. Li, C.J., Nanji, A.A., Siakotos, A.N., Lin, R.C. Hepatology (1997)
- Inactivation of glucose-6-phosphate dehydrogenase by 4-hydroxy-2-nonenal. Selective modification of an active-site lysine. Szweda, L.I., Uchida, K., Tsai, L., Stadtman, E.R. J. Biol. Chem. (1993)
- Oxidative modification and inactivation of the proteasome during coronary occlusion/reperfusion. Bulteau, A.L., Lundberg, K.C., Humphries, K.M., Sadek, H.A., Szweda, P.A., Friguet, B., Szweda, L.I. J. Biol. Chem. (2001)
- Mutual dependence of growth modifying effects of 4-hydroxynonenal and fetal calf serum in vitro. Zarkovic, N., Schaur, R.J., Puhl, H., Jurin, M., Esterbauer, H. Free Radic. Biol. Med. (1994)
- Formation of 8-hydroxy-2'-deoxyguanosine and 4-hydroxy-2-nonenal-modified proteins in human renal-cell carcinoma. Okamoto, K., Toyokuni, S., Uchida, K., Ogawa, O., Takenewa, J., Kakehi, Y., Kinoshita, H., Hattori-Nakakuki, Y., Hiai, H., Yoshida, O. Int. J. Cancer (1994)
- Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis. Kruman, I., Bruce-Keller, A.J., Bredesen, D., Waeg, G., Mattson, M.P. J. Neurosci. (1997)
- Overexpression of mitochondrial manganese superoxide dismutase protects against radiation-induced cell death in the human hepatocellular carcinoma cell line HLE. Motoori, S., Majima, H.J., Ebara, M., Kato, H., Hirai, F., Kakinuma, S., Yamaguchi, C., Ozawa, T., Nagano, T., Tsujii, H., Saisho, H. Cancer Res. (2001)
- 4-Hydroxynonenal, a product of cellular lipid peroxidation, which modulates c-myc and globin gene expression in K562 erythroleukemic cells. Fazio, V.M., Barrera, G., Martinotti, S., Farace, M.G., Giglioni, B., Frati, L., Manzari, V., Dianzani, M.U. Cancer Res. (1992)
- Metabolism of 4-hydroxynonenal, a cytotoxic lipid peroxidation product, in Ehrlich mouse ascites cells at different proliferation stages. Grune, T., Siems, W.G., Zollner, H., Esterbauer, H. Cancer Res. (1994)
- Immunochemical detection of 4-hydroxynonenal protein adducts in oxidized hepatocytes. Uchida, K., Szweda, L.I., Chae, H.Z., Stadtman, E.R. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Mitochondrial adenine nucleotide translocase is modified oxidatively during aging. Yan, L.J., Sohal, R.S. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Electrophysiological effects of 4-hydroxynonenal, an aldehydic product of lipid peroxidation, on isolated rat ventricular myocytes. Bhatnagar, A. Circ. Res. (1995)
- Mitochondrial electron transport complex I is a potential source of oxygen free radicals in the failing myocardium. Ide, T., Tsutsui, H., Kinugawa, S., Utsumi, H., Kang, D., Hattori, N., Uchida, K., Arimura, K., Egashira, K., Takeshita, A. Circ. Res. (1999)
- Tissue-destructive macrophages in giant cell arteritis. Rittner, H.L., Kaiser, M., Brack, A., Szweda, L.I., Goronzy, J.J., Weyand, C.M. Circ. Res. (1999)
- Formation of 4-hydroxy-2-nonenal-modified proteins in the renal proximal tubules of rats treated with a renal carcinogen, ferric nitrilotriacetate. Toyokuni, S., Uchida, K., Okamoto, K., Hattori-Nakakuki, Y., Hiai, H., Stadtman, E.R. Proc. Natl. Acad. Sci. U.S.A. (1994)
- Declines in mitochondrial respiration during cardiac reperfusion: age-dependent inactivation of alpha-ketoglutarate dehydrogenase. Lucas, D.T., Szweda, L.I. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Stimulation of collagen alpha 1(I) gene expression is associated with lipid peroxidation in hepatocellular injury: a link to tissue fibrosis? Bedossa, P., Houglum, K., Trautwein, C., Holstege, A., Chojkier, M. Hepatology (1994)
- Delivery of IkappaB superrepressor gene with adenovirus reduces early alcohol-induced liver injury in rats. Uesugi, T., Froh, M., Arteel, G.E., Bradford, B.U., Gäbele, E., Wheeler, M.D., Thurman, R.G. Hepatology (2001)
- Enhancement by pyrazole of lipopolysaccharide-induced liver injury in mice: role of cytochrome P450 2E1 and 2A5. Lu, Y., Cederbaum, A.I. Hepatology (2006)
- Human aldehyde dehydrogenase 3A1 inhibits proliferation and promotes survival of human corneal epithelial cells. Pappa, A., Brown, D., Koutalos, Y., DeGregori, J., White, C., Vasiliou, V. J. Biol. Chem. (2005)
- A lipid peroxidation-derived inflammatory mediator: identification of 4-hydroxy-2-nonenal as a potential inducer of cyclooxygenase-2 in macrophages. Kumagai, T., Matsukawa, N., Kaneko, Y., Kusumi, Y., Mitsumata, M., Uchida, K. J. Biol. Chem. (2004)
- The reactive oxygen species--and Michael acceptor-inducible human aldo-keto reductase AKR1C1 reduces the alpha,beta-unsaturated aldehyde 4-hydroxy-2-nonenal to 1,4-dihydroxy-2-nonene. Burczynski, M.E., Sridhar, G.R., Palackal, N.T., Penning, T.M. J. Biol. Chem. (2001)
- Model of nonalcoholic steatohepatitis. Lieber, C.S., Leo, M.A., Mak, K.M., Xu, Y., Cao, Q., Ren, C., Ponomarenko, A., DeCarli, L.M. Am. J. Clin. Nutr. (2004)
- Structure of a Drosophila sigma class glutathione S-transferase reveals a novel active site topography suited for lipid peroxidation products. Agianian, B., Tucker, P.A., Schouten, A., Leonard, K., Bullard, B., Gros, P. J. Mol. Biol. (2003)
- Free radical-dependent dysfunction of small-for-size rat liver grafts: prevention by plant polyphenols. Zhong, Z., Connor, H.D., Froh, M., Bunzendahl, H., Lind, H., Lehnert, M., Mason, R.P., Thurman, R.G., Lemasters, J.J. Gastroenterology (2005)
- Cardiac reperfusion injury: aging, lipid peroxidation, and mitochondrial dysfunction. Lucas, D.T., Szweda, L.I. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Induction of vascular endothelial growth factor in balloon-injured baboon arteries. A novel role for reactive oxygen species in atherosclerosis. Ruef, J., Hu, Z.Y., Yin, L.Y., Wu, Y., Hanson, S.R., Kelly, A.B., Harker, L.A., Rao, G.N., Runge, M.S., Patterson, C. Circ. Res. (1997)
- Cardiac mitochondrial NADP+-isocitrate dehydrogenase is inactivated through 4-hydroxynonenal adduct formation: an event that precedes hypertrophy development. Benderdour, M., Charron, G., DeBlois, D., Comte, B., Des Rosiers, C. J. Biol. Chem. (2003)
- Androgenic regulation of oxidative stress in the rat prostate: involvement of NAD(P)H oxidases and antioxidant defense machinery during prostatic involution and regrowth. Tam, N.N., Gao, Y., Leung, Y.K., Ho, S.M. Am. J. Pathol. (2003)