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Chemical Compound Review

CHEMBL454280     (E)-4-hydroxynon-2-enal

Synonyms: CCRIS 1781, CCRIS 6927, CCRIS 9028, CHEBI:32585, CHEBI:58968, ...
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Disease relevance of CCRIS 6927


Psychiatry related information on CCRIS 6927


High impact information on CCRIS 6927


Chemical compound and disease context of CCRIS 6927


Biological context of CCRIS 6927


Anatomical context of CCRIS 6927


Associations of CCRIS 6927 with other chemical compounds


Gene context of CCRIS 6927


Analytical, diagnostic and therapeutic context of CCRIS 6927


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  6. Immunohistochemical detection of 4-hydroxy-2-nonenal adducts in Alzheimer's disease is associated with inheritance of APOE4. Montine, K.S., Olson, S.J., Amarnath, V., Whetsell, W.O., Graham, D.G., Montine, T.J. Am. J. Pathol. (1997) [Pubmed]
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  15. Inactivation of glucose-6-phosphate dehydrogenase by 4-hydroxy-2-nonenal. Selective modification of an active-site lysine. Szweda, L.I., Uchida, K., Tsai, L., Stadtman, E.R. J. Biol. Chem. (1993) [Pubmed]
  16. Oxidative modification and inactivation of the proteasome during coronary occlusion/reperfusion. Bulteau, A.L., Lundberg, K.C., Humphries, K.M., Sadek, H.A., Szweda, P.A., Friguet, B., Szweda, L.I. J. Biol. Chem. (2001) [Pubmed]
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  18. Formation of 8-hydroxy-2'-deoxyguanosine and 4-hydroxy-2-nonenal-modified proteins in human renal-cell carcinoma. Okamoto, K., Toyokuni, S., Uchida, K., Ogawa, O., Takenewa, J., Kakehi, Y., Kinoshita, H., Hattori-Nakakuki, Y., Hiai, H., Yoshida, O. Int. J. Cancer (1994) [Pubmed]
  19. Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis. Kruman, I., Bruce-Keller, A.J., Bredesen, D., Waeg, G., Mattson, M.P. J. Neurosci. (1997) [Pubmed]
  20. Overexpression of mitochondrial manganese superoxide dismutase protects against radiation-induced cell death in the human hepatocellular carcinoma cell line HLE. Motoori, S., Majima, H.J., Ebara, M., Kato, H., Hirai, F., Kakinuma, S., Yamaguchi, C., Ozawa, T., Nagano, T., Tsujii, H., Saisho, H. Cancer Res. (2001) [Pubmed]
  21. 4-Hydroxynonenal, a product of cellular lipid peroxidation, which modulates c-myc and globin gene expression in K562 erythroleukemic cells. Fazio, V.M., Barrera, G., Martinotti, S., Farace, M.G., Giglioni, B., Frati, L., Manzari, V., Dianzani, M.U. Cancer Res. (1992) [Pubmed]
  22. Metabolism of 4-hydroxynonenal, a cytotoxic lipid peroxidation product, in Ehrlich mouse ascites cells at different proliferation stages. Grune, T., Siems, W.G., Zollner, H., Esterbauer, H. Cancer Res. (1994) [Pubmed]
  23. Immunochemical detection of 4-hydroxynonenal protein adducts in oxidized hepatocytes. Uchida, K., Szweda, L.I., Chae, H.Z., Stadtman, E.R. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  24. Mitochondrial adenine nucleotide translocase is modified oxidatively during aging. Yan, L.J., Sohal, R.S. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
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  26. Mitochondrial electron transport complex I is a potential source of oxygen free radicals in the failing myocardium. Ide, T., Tsutsui, H., Kinugawa, S., Utsumi, H., Kang, D., Hattori, N., Uchida, K., Arimura, K., Egashira, K., Takeshita, A. Circ. Res. (1999) [Pubmed]
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  28. Formation of 4-hydroxy-2-nonenal-modified proteins in the renal proximal tubules of rats treated with a renal carcinogen, ferric nitrilotriacetate. Toyokuni, S., Uchida, K., Okamoto, K., Hattori-Nakakuki, Y., Hiai, H., Stadtman, E.R. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
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  31. Delivery of IkappaB superrepressor gene with adenovirus reduces early alcohol-induced liver injury in rats. Uesugi, T., Froh, M., Arteel, G.E., Bradford, B.U., Gäbele, E., Wheeler, M.D., Thurman, R.G. Hepatology (2001) [Pubmed]
  32. Enhancement by pyrazole of lipopolysaccharide-induced liver injury in mice: role of cytochrome P450 2E1 and 2A5. Lu, Y., Cederbaum, A.I. Hepatology (2006) [Pubmed]
  33. Human aldehyde dehydrogenase 3A1 inhibits proliferation and promotes survival of human corneal epithelial cells. Pappa, A., Brown, D., Koutalos, Y., DeGregori, J., White, C., Vasiliou, V. J. Biol. Chem. (2005) [Pubmed]
  34. A lipid peroxidation-derived inflammatory mediator: identification of 4-hydroxy-2-nonenal as a potential inducer of cyclooxygenase-2 in macrophages. Kumagai, T., Matsukawa, N., Kaneko, Y., Kusumi, Y., Mitsumata, M., Uchida, K. J. Biol. Chem. (2004) [Pubmed]
  35. The reactive oxygen species--and Michael acceptor-inducible human aldo-keto reductase AKR1C1 reduces the alpha,beta-unsaturated aldehyde 4-hydroxy-2-nonenal to 1,4-dihydroxy-2-nonene. Burczynski, M.E., Sridhar, G.R., Palackal, N.T., Penning, T.M. J. Biol. Chem. (2001) [Pubmed]
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  37. Structure of a Drosophila sigma class glutathione S-transferase reveals a novel active site topography suited for lipid peroxidation products. Agianian, B., Tucker, P.A., Schouten, A., Leonard, K., Bullard, B., Gros, P. J. Mol. Biol. (2003) [Pubmed]
  38. Free radical-dependent dysfunction of small-for-size rat liver grafts: prevention by plant polyphenols. Zhong, Z., Connor, H.D., Froh, M., Bunzendahl, H., Lind, H., Lehnert, M., Mason, R.P., Thurman, R.G., Lemasters, J.J. Gastroenterology (2005) [Pubmed]
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  40. Induction of vascular endothelial growth factor in balloon-injured baboon arteries. A novel role for reactive oxygen species in atherosclerosis. Ruef, J., Hu, Z.Y., Yin, L.Y., Wu, Y., Hanson, S.R., Kelly, A.B., Harker, L.A., Rao, G.N., Runge, M.S., Patterson, C. Circ. Res. (1997) [Pubmed]
  41. Cardiac mitochondrial NADP+-isocitrate dehydrogenase is inactivated through 4-hydroxynonenal adduct formation: an event that precedes hypertrophy development. Benderdour, M., Charron, G., DeBlois, D., Comte, B., Des Rosiers, C. J. Biol. Chem. (2003) [Pubmed]
  42. Androgenic regulation of oxidative stress in the rat prostate: involvement of NAD(P)H oxidases and antioxidant defense machinery during prostatic involution and regrowth. Tam, N.N., Gao, Y., Leung, Y.K., Ho, S.M. Am. J. Pathol. (2003) [Pubmed]
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