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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Fission yeast cdc25 is a cell-cycle regulated protein.

Fission yeast cell division is initiated by the cdc2/cdc13-cyclin protein kinase which in its catalytically active state comprises the mitotic inducer. During interphase the cdc2/cyclin complex is assembled in an inactive state that requires cdc25+ gene function for M-phase activation. The cdc25+ product, a 76 kd phosphoprotein, is shown to oscillate in abundance during the cell cycle, reaching a peak at G2/M, and to be sensitive to nitrogen starvation. The level of cdc25 is subject to feedback regulation involving both cdc25 and cdc2.[1]


  1. Fission yeast cdc25 is a cell-cycle regulated protein. Ducommun, B., Draetta, G., Young, P., Beach, D. Biochem. Biophys. Res. Commun. (1990) [Pubmed]
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