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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Highly specific, sensitive and rapid enzyme immunoassays for the measurement of acetaminophen in serum.

Acetaminophen antibodies were purified using affinity chromatography and labelled with horseradish peroxidase (HRP). The antibody-HRP conjugate and a new acetaminophen derivative were used in the construction of two immunoassay methods facilitating the direct quantitative measurement of acetaminophen in serum: a 96-well microtitre plate and coated-tube ELISAs. A minimum detection limit of 0.2 μg mL(-1) and a dynamic range of 0.2 to 10 μg mL(-1) in serum were achieved using the 96-well microtitre plate ELISA. The tube assay was optimised for the measurement of the clinically critical acetaminophen concentration of 50 to 250 μg mL(-1) of serum. The quantitative and specific tests could be completed within less than an hour. Common drugs including aspirin showed less than 0.1% cross-reactivity.[1]

References

  1. Highly specific, sensitive and rapid enzyme immunoassays for the measurement of acetaminophen in serum. Abuknesha, R.A., Paleodimos, M., Jeganathan, F. Anal. Bioanal. Chem (2011) [Pubmed]
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