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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Increased frequency of first-episode poststroke depression after discontinuation of escitalopram.

BACKGROUND AND PURPOSE: The purpose of this study was to compare escitalopram, problem-solving therapy, and placebo to prevent poststroke depression during 6 months after discontinuation of treatment. METHODS: We examined for depression 33 patients assigned to placebo, 34 to escitalopram, and 41 to problem-solving therapy. RESULTS: After controlling for age, gender, prior mood disorder, and severity of stroke, new-onset major depression and Hamilton Depression scores were significantly higher 6 months after escitalopram was discontinued compared with the problem-solving therapy or placebo groups. CONCLUSIONS: Discontinuation of escitalopram may increase poststroke depressive symptoms. Clinical Trial Registration- URL: http://www.clinicaltrials.gov. Unique identifier: NCT00071643.[1]

References

  1. Increased frequency of first-episode poststroke depression after discontinuation of escitalopram. Mikami, K., Jorge, R.E., Moser, D.J., Arndt, S., Jang, M., Solodkin, A., Small, S.L., Fonzetti, P., Hegel, M.T., Robinson, R.G. Stroke (2011) [Pubmed]
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